Opposed view and dual head detector apparatus for diagnosis and biopsy with image processing methods

• US 8,200,316 B2
• Filed: 01/15/2010
• Issued: 06/12/2012
• Est. Priority Date: 10/04/2006
• Status: Active Grant

• Current Assignee: Hampton University
• Original Assignee: Hampton University
• Inventors: Keppel, Cynthia, Kieper, Douglas
• Primary Examiner(s): Casler, Brian
• Assistant Examiner(s): Lamprecht, Joel
• Application Number:
  US12/688,509
• Publication Number:
  US 20100183213A1
• Time in Patent Office: 879 Days
• Field of Search: 600/436, 600/130, 600/425, 600/427, 600/431, 600/407, 424/9.1
• US Class Current: 600/436
• CPC Class Codes: A61B 2090/3908 Soft tissue, e.g. breast tissue
• CPC Class Codes: A61B 2090/392 Radioactive markers
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/469 for selecting a region of interest [ROI]
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 6/583 using calibration phantoms
• CPC Class Codes: A61B 90/11 with guides for needles or instruments, e.g. arcuate slides or ball joints

Abstract

The invention relates generally to biopsy needle guidance which employs an x-ray/gamma image spatial co-registration methodology. A gamma camera is configured to mount on a biopsy needle gun platform to obtain a gamma image. More particular, the spatially co-registered x-ray and physiological images may be employed for needle guidance during biopsy. Moreover, functional images may be obtained from a gamma camera at various angles relative to a target site. Further, the invention also generally relates to a breast lesion localization method using opposed gamma camera images or dual opposed images. This dual head methodology may be used to compare the lesion signal in two opposed detector images and to calculate the Z coordinate (distance from one or both of the detectors) of the lesion.

Claims

1. An apparatus for determining lesion location within a target site in a patient, comprising:

at least one photon imaging device, wherein said at least one photon imaging device is movable with respect to the target site such that said at least one photon imaging device acquires a plurality of images relative to the target site, wherein a signal intensity for the plurality of images is obtained from opposed positions; and

a controller configured to;

control movement of said at least one photon imaging device;

receive images from said at least one photon imaging device and to receive the signal intensity for each of the plurality of images; and

calculate the lesion location within the target site in the patient based upon the plurality of images acquired by said at least one imaging device using the obtained signal intensities from only a single set of mutually opposing positions.

2. The apparatus of claim 1, further comprising at least one gantry for mounting the at least one photon imaging device.

3. The apparatus of claim 2, wherein said at least one photon imaging device is a plurality of photon imaging devices.

4. The apparatus of claim 3, wherein the plurality of photon imaging devices includes a first photon imaging device comprising an x-ray generator mounted on said at least one gantry, a second photon imaging device comprising an x-ray detector mounted on said at least one gantry, and a third photon imaging device comprising a gamma camera mounted on said at least one gantry.

5. The apparatus of claim 4, wherein a fourth imaging device is a gamma camera mounted on said at least one gantry.

6. The apparatus of claim 4, wherein said at least one gantry is a plurality of gantries and said first photon imaging device and third photon imaging device are each mounted on separate gantries, wherein the separate gantries are movable with respect to each another.

7. The apparatus of claim 2, wherein said at last one gantry is a plurality of gantries and a first photon imaging device is a gamma camera mounted on a first gantry of said plurality of gantries, a second imaging device is an x-ray generator mounted on a second gantry of said plurality of gantries, and a third imaging device is an x-ray detector mounted on said second gantry.

8. The apparatus of claim 7, wherein a fourth photon imaging device is a gamma camera mounted on said first gantry.

9. The apparatus of claim 7, wherein said first gantry and said second gantry are concentric rings moveable with respect to each other.

10. The apparatus of claim 1, wherein said apparatus further comprises a pair of compression paddles.

11. The apparatus of claim 1, wherein the controller is configured to control movement of said at least one photon imaging device to image the target site, the target site being one or more sites selected from the group consisting of:

breast, thyroid, parathyroid, heart, liver, kidney, gall bladder, bladder, reproductive organs and glandular structures.

12. The apparatus of claim 1, wherein the comparative signal intensity includes a comparative signal intensity calculated from at least one of:

comparing changes in attenuation, comparing changes in spatial resolution and comparing changes in partial volume effect.

13. The apparatus of claim 1, wherein the comparative signal intensity includes a comparative signal intensity calculated from at least two of:

comparing changes in attenuation, comparing changes in spatial resolution and comparing changes in partial volume effect.

14. An apparatus for determining lesion location within a target site in a patient, comprising:

means for receiving a plurality of images using photon imaging of the target site from a single set of opposing positions;

means for receiving a measured signal intensity simultaneously at each opposing positions; and

means for calculating a lesion spatial location within the target site based upon the acquired plurality of images and based upon a comparative signal intensity calculated using the received measured signal intensities at the single set of opposing positions.

15. The apparatus of claim 14, wherein said means for receiving a plurality of images includes using gamma imaging.

16. The apparatus of claim 14, wherein the means for receiving a plurality of images includes using x-ray imaging.

17. The apparatus of claim 14, wherein said means for calculating calculates a Z-coordinate of the lesion spatial location in part based upon attenuated signal intensity changes from the opposing positions.

18. The apparatus of claim 14, wherein said means for calculating calculates a Z-coordinate of the lesion location in part based upon a difference in signal intensity measured at each of the opposing positions.

19. The apparatus of claim 14, wherein the means for calculating calculates a Z-coordinate that includes comparing signal intensity calculated from a plurality of signal intensities detected at 180 degree opposing positions.

20. The apparatus of claim 14, wherein a difference in measured signal intensity at each of the opposing positions is indicative of a relative position of the lesion from the opposed position.

21. The apparatus of claim 14, wherein the comparative signal intensity is calculated using the received signal intensities at each of the opposing positions and is indicative of relative distance of the lesion from the opposing positions.

22. The apparatus of claim 14, wherein the opposing positions are 180 degrees opposed and the signal intensity is calculated using a difference in detected intensities at each opposed position.

23. The apparatus of claim 14, wherein the received plurality of images are received based in part on an emission of a single gamma emitting isotope.

24. The apparatus of claim 14, further including means for comparing signal intensities using the received measured signal intensities, the means for comparing includes performing at least one of:

comparing changes in attenuation, comparing changes in spatial resolution and comparing changes in partial volume effect.

25. The apparatus of claim 14, wherein the comparative signal intensity includes a comparative signal intensity calculated based on at least one of:

comparing changes in attenuation, comparing changes in spatial resolution and comparing changes in partial volume effect.

26. The apparatus of claim 14, wherein the comparative signal intensity includes a comparative signal intensity calculated from at least two of:

comparing changes in attenuation, comparing changes in spatial resolution and comparing changes in partial volume effect.