Method for tuning patient-specific cardiovascular simulations
First Claim
1. A system for determining cardiovascular information for a patient, the system comprising:
- at least one computer system configured to;
receive patient-specific data regarding a geometry of an anatomical structure of the patient;
create, based on the patient-specific data, a three-dimensional model representing at least a portion of the aorta of the patient and at least a portion of a plurality of vessels emanating from the portion of the aorta, the three-dimensional model including portions representing at least one inlet and a plurality of outlets for blood flow;
create a three-dimensional mesh based on the three-dimensional model;
create at least one boundary condition model having less than three dimensions, the at least one boundary condition model representing blood flow through at least one of the at least one inlet or the plurality of outlets;
determine a blood flow characteristic within the anatomical structure of the patient by solving equations governing blood flow using the three-dimensional mesh and the at least one boundary condition model; and
automatically tune at least one parameter of the three-dimensional model or the at least one boundary condition model.
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Abstract
Computational methods are used to create cardiovascular simulations having desired hemodynamic features. Cardiovascular modeling methods produce descriptions of blood flow and pressure in the heart and vascular networks. Numerical methods optimize and solve nonlinear equations to find parameter values that result in desired hemodynamic characteristics including related flow and pressure at various locations in the cardiovascular system, movements of soft tissues, and changes for different physiological states. The modeling methods employ simplified models to approximate the behavior of more complex models with the goal of to reducing computational expense. The user describes the desired features of the final cardiovascular simulation and provides minimal input, and the system automates the search for the final patient-specific cardiovascular model.
240 Citations
31 Claims
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1. A system for determining cardiovascular information for a patient, the system comprising:
at least one computer system configured to; receive patient-specific data regarding a geometry of an anatomical structure of the patient; create, based on the patient-specific data, a three-dimensional model representing at least a portion of the aorta of the patient and at least a portion of a plurality of vessels emanating from the portion of the aorta, the three-dimensional model including portions representing at least one inlet and a plurality of outlets for blood flow; create a three-dimensional mesh based on the three-dimensional model; create at least one boundary condition model having less than three dimensions, the at least one boundary condition model representing blood flow through at least one of the at least one inlet or the plurality of outlets; determine a blood flow characteristic within the anatomical structure of the patient by solving equations governing blood flow using the three-dimensional mesh and the at least one boundary condition model; and automatically tune at least one parameter of the three-dimensional model or the at least one boundary condition model. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method for determining patient-specific cardiovascular information using at least one computer system, the method comprising:
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inputting into the at least one computer system patient-specific data regarding a geometry of an anatomical structure of the patient; creating, using the at least one computer system and based on the patient-specific data, a three-dimensional model representing at least a portion of the aorta of the patient and at least a portion of a plurality of vessels emanating from the portion of the aorta, the three-dimensional model including portions representing at least one inlet and a plurality of outlets for blood flow; creating a three-dimensional mesh based on the three-dimensional model; creating at least one first model having less than three dimensions, the at least one first model representing blood flow through at least one of the at least one inlet or the plurality of outlets; determining, using the at least one computer system, a blood flow characteristic within the anatomical structure of the patient by solving equations governing blood flow using the three-dimensional mesh and the at least one first model; and creating at least one second model having less than three dimensions, the at least one second model representing at least a portion of the three-dimensional model of the patient and created based on the patient-specific data and on the determined blood flow characteristic. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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29. A non-transitory computer readable medium for use on at least one computer system containing computer-executable programming instructions for performing a method for determining patient-specific cardiovascular information, the method comprising:
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receiving patient-specific data regarding a geometry of an anatomical structure of the patient; creating, based on the patient-specific data, a three-dimensional model representing at least a portion of the aorta of the patient and at least a portion of a plurality of vessels emanating from the portion of the aorta, the three-dimensional model including at least one inlet for blood flow and a plurality of outlets for blood flow; creating a three-dimensional mesh based on the three-dimensional model; creating at least one boundary condition model having less than three dimensions, the at least one boundary condition model representing blood flow through at least one of the at least one inlet or the plurality of outlets; determining a blood flow characteristic within the anatomical structure of the patient by solving equations governing blood flow using the three-dimensional mesh and the at least one boundary condition model; and automatically tuning at least one parameter of the three-dimensional model or the at least one boundary condition model. - View Dependent Claims (30, 31)
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Specification