System and method for calibrating cardiac pressure measurements derived from signals detected by an implantable medical device

• US 8,202,224 B2
• Filed: 04/24/2008
• Issued: 06/19/2012
• Est. Priority Date: 11/13/2006
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Gutfinger, Dan E., Eigler, Neal L., Panescu, Dorin, Whiting, James S.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): PORTER, JR, GARY A
• Application Number:
  US12/109,304
• Publication Number:
  US 20080262361A1
• Time in Patent Office: 1,517 Days
• Field of Search: 600/485, 600/486, 600/506, 600/508, 600/513, 600/517, 600/526, 600/547, 607/17, 607/23
• US Class Current: 600/485
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive

Abstract

Various techniques are provided for calibrating and estimating left atrial pressure (LAP) using an implantable medical device, based on impedance, admittance or conductance parameters measured within a patient. In one example, default conversion factors are exploited for converting the measured parameters to estimates of LAP. The default conversion factors are derived from populations of patients. In another example, a correlation between individual conversion factors is exploited to allow for more efficient calibration. In yet another example, differences in thoracic fluid states are exploited during calibration. In still yet another example, a multiple stage calibration procedure is described, wherein both invasive and noninvasive calibration techniques are exploited. In a still further example, a therapy control procedure is provided, which exploits day time and night time impedance/admittance measurements.

Claims

1. A method for estimating cardiac pressure within a patient using an implantable medical device wherein the estimation exploits conversion factors representative of a correlation between a measured electrical parameter within the patient and the cardiac pressure of the patient, the method comprising:

determining a set of conversion factors for converting measured electrical parameters to estimates of cardiac pressure, wherein the conversion factors are determined, at least in part, based on a physiological state of the patient and wherein the physiological state is either an acute state wherein an acute change of fluid volume within the intra-vascular fluid compartment of the patient does not substantially affect the fluid volume within the interstitial fluid compartment of the patient or a chronic state wherein fluid volume between the intra-vascular and interstitial fluid compartments of the patient has substantially equilibrated; and

estimating cardiac pressure within the patient by applying a first set of conversion factors to measured electrical parameters when the patient is in the acute state and a second set of conversion factors to measured electrical parameters when the patient is in the chronic state.

2. The method of claim 1 wherein determining the set of conversion factors includes:

inputting a first set of conversion factors appropriate for converting electrical parameters measured while the patient is in the acute state;

inputting an adjustment factor for use in adjusting the first set of conversion factors to yield a second set of conversion factors appropriate for use with electrical parameters measured while the patient is in the chronic state; and

applying the adjustment factor to the first set of conversion factors to generate the second set of conversion factors.

3. The method of claim 2 wherein the first and second sets of conversion factors include slope and baseline values representative of a linear relationship between the measured parameter and cardiac pressure and wherein the adjustment factor is applied only to the slope value.

4. The method of claim 3 wherein the slope of the first set of conversion factors is adjusted by dividing the slope by adjustment factor in the range of 3 to 5 to yield the slope of the second set of conversion factors.

5. The method of claim 2 wherein adjustment factor is specific to the particular patient in which the device is implanted.

6. The method of claim 1 wherein determining the set of conversion factors includes:

determining the current patient physiological state of the patient; and

retrieving and applying the appropriate set of conversion factors for the current physiological state.

7. The method of claim 6 wherein the implantable device stores a first set of conversion factors appropriate for use in the acute state and a second set of conversion factors appropriate for use in the chronic state.

8. A method for estimating cardiac pressure within a patient using an implantable medical device wherein the estimation exploits conversion factors representative of a correlation between a measured electrical parameter within the patient and the cardiac pressure of the patient, the method comprising:

determining a set of conversion factors for converting measured electrical parameters to estimates of cardiac pressure, wherein determining the set of conversion factors includes;

determining a first set of acute conversion factors based, at least in part, on calibration parameters measured while the patient is in an acute physiological state affecting only the fluid volume within the intra-vascular fluid compartment; and

determining a second set of chronic conversion factors based, at least in part, on calibration parameters measured while the patient is in a chronic steady state in which the fluid volume within the intra-vascular and interstitial fluid compartments have equilibrated; and

estimating cardiac pressure within the patient by applying the first set of conversion factors to measured electrical parameters if the patient is in the acute physiological state and applying the second set of conversion factors to measured electrical parameters if the patient is in the chronic steady state.