Blood purification system

• US 8,202,241 B2
• Filed: 02/14/2008
• Issued: 06/19/2012
• Est. Priority Date: 02/15/2007
• Status: Expired due to Fees

• Current Assignee: Asahi Kasei Medical Co., Ltd. (Asahi Kasei Corporation)
• Original Assignee: Asahi Kasei Medical Co., Ltd. (Asahi Kasei Corporation)
• Inventors: Karakama, Atsushi, Okazaki, Soichiro
• Primary Examiner(s): Deak, Leslie
• Assistant Examiner(s): Xie, Xin
• Application Number:
  US12/527,270
• Publication Number:
  US 20100087771A1
• Time in Patent Office: 1,587 Days
• Field of Search: 210/85, 210/86, 210/97, 210/103, 210/104, 210/110, 210/134, 210/137, 210/143, 210/252, 210/257.2, 210/321.72, 210/645, 210/646, 210/739, 210/744, 604/4.01, 604/6.01, 604/6.1, 604/6.11, 604/6.16
• US Class Current: 604/6.1
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/1643 with weighing of fresh and used dialysis fluid
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/3431 upstream of the filter
• CPC Class Codes: A61M 1/3437 downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3441 Substitution rate control as a function of the ultrafiltration rate
• CPC Class Codes: A61M 1/3451 the difference in weight between both ultra-filtrate and substitution reservoir being used as control signal
• CPC Class Codes: A61M 1/3455 Substitution fluids
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir

Abstract

Provision of a blood purification system comprising a blood purification tubing and a blood purification apparatus particularly suitable for use in continuous hemofiltration in which in the treatment of a patient with renal disease, multiple organ failure, and the like, the amount of water removed from the patient and the amount of supply to the patient can be more accurately controlled, and in which preparation operation is easy. A blood purification system comprising a blood purification tubing and a blood purification apparatus wherein the soft tubes of flow paths connecting a first planar panel and a second planar panel, and the location of the soft tubes are selected to satisfy a formula of a predetermined condition.

Claims

1. A blood purification system comprising a blood purification tubing and a blood purification apparatus, wherein

the blood purification tubing has a blood drawing tubing part for feeding blood drawn from a patient to a blood purifier, a blood returning tubing part for returning blood in the blood purifier to the patient, a dialysate supplying tubing part for supplying a dialysate to the blood purifier, a drainage tubing part for performing drainage from the blood purifier, and a replacement fluid supplying tubing part for supplying a replacement fluid to the blood drawing tubing part or the blood returning tubing part,

the dialysate supplying tubing part has a dialysate storage container,

the drainage tubing part has a drainage storage container,

the replacement fluid supplying tubing part has a replacement fluid storage container,

the dialysate supplying tubing part, the drainage tubing part, and the replacement fluid supplying tubing part are each located to pass in a first planar panel and in a second planar panel,

the dialysate storage container, the drainage storage container, and the replacement fluid storage container are installed in the second planar panel,

flow paths connecting the first planar panel and the second planar panel, in the dialysate supplying tubing part, the drainage tubing part, and the replacement fluid supplying tubing part, are composed of a soft tube,

the blood purification apparatus has a scale for measuring the second planar panel, and

the soft tubes and location of the soft tubes are selected to satisfy the following formulas (1) and (2) when a weight of the second planar panel, with the three storage containers being empty, is B, a value obtained by subtracting the weight B from a weight of the second planar panel, with a liquid having a weight W placed only in the drainage storage container, is Wf, a value obtained by subtracting the weight B from a weight of the second planar panel, with a liquid having the weight W placed only in the dialysate storage container, is Wd, and a value obtained by subtracting the weight B from a weight of the second planar panel, with a liquid having the weight W placed only in the replacement fluid storage container, is Wr, and when each weight of B, Wf, Wd, and Wr is obtained from a numerical value measured by the scale of the blood purification apparatus

|Wf−

Wr|/W≦

0.005 

 

(1)

|Wf−

Wd|/W≦

0.005 

 

(2).

2. The blood purification system according to claim 1, wherein

one end side of the soft tube is connected at an end α

on the second planar panel, and the other end side is connected at an end β

on the first planar panel, and

the soft tube is located so that

when an axial direction in an arbitrary portion χ

in a longitudinal direction of the soft tube connecting the end α and

the end β

is a vector X,

a gravity direction is a vector G, and

a narrower angle formed by the vector X and the vector G is an angle θ

X,

at least one portion χ

in which the angle θ

X is 70°

to 110°

is present,

provided that the vector X is a direction from the second planar panel toward the first planar panel.

3. The blood purification system according to claim 1, wherein

the blood purification tubing further has a dialysate feed pump tube, a replacement fluid feed pump tube, and a drainage feed pump tube,

the blood purification apparatus further has a dialysate feed pump, a replacement fluid feed pump, and a drainage feed pump for squeezing the pump tubes for feeding,

in the dialysate supplying tubing part, the dialysate feed pump tube, a dialysate branch duct, and a dialysate supply blocking part are located in this order from a dialysate inlet side of the blood purifier on a tubing having one end side connected to a dialysate inlet of the blood purifier and the other end side connected to a dialysate storage part, and the dialysate storage container is connected to the dialysate branch duct,

in the replacement fluid supplying tubing part, the replacement fluid feed pump tube, a replacement fluid branch duct, and a replacement fluid supply blocking part are located in this order from a blood returning tubing part or blood drawing tubing part side on a tubing having one end side connected to the blood returning tubing part or the blood drawing tubing part and the other end side connected to a replacement fluid storage part, and the replacement fluid storage container is connected to the replacement fluid branch duct,

in the drainage tubing part, the drainage feed pump tube, a drainage branch duct, and a drainage blocking part are located in this order from a drainage outlet side of the blood purifier on a tubing having one end side connected to a drainage outlet of the blood purifier and the other end side open, and the drainage storage container is connected to the drainage branch duct,

the blood purification apparatus further has a dialysate supply blocking valve, a replacement fluid supply blocking valve, and a drainage blocking valve for blocking the blocking parts,

a flow path in a portion near the dialysate feed pump tube and between the dialysate inlet of the blood purifier and the dialysate feed pump tube, and a flow path in a portion near the dialysate feed pump tube and between the dialysate feed pump tube and an end connected to the dialysate storage part, in the dialysate supplying tubing part,

a flow path in a portion near the replacement fluid feed pump tube and between an end connected to the blood returning tubing part or the blood drawing tubing part and the replacement fluid feed pump tube, and a flow path in a portion near the replacement fluid feed pump tube and between the replacement fluid feed pump tube and an end on the side connected to the replacement fluid storage part, in the replacement fluid supplying tubing part, and

a flow path in a portion near the drainage feed pump tube and between the drainage outlet of the blood purifier and the drainage feed pump tube, and a flow path in a portion near the drainage feed pump tube and between the drainage feed pump tube and an open end, in the drainage tubing part

are installed in the first planar panel,

the dialysate feed pump tube, the replacement fluid feed pump tube, and the drainage feed pump tube are connected to the first planar panel, and

the dialysate branch duct, the replacement fluid branch duct, and the drainage branch duct are installed in the first planar panel or the second planar panel.

4. The blood purification system according to claim 3, wherein

the blood purification apparatus has a heating apparatus,

the flow path in the portion near the dialysate feed pump tube and between the dialysate inlet of the blood purifier and the dialysate feed pump tube in the dialysate supplying tubing part, installed in the first planar panel, is a dialysate heating flow path, the flow path in the portion near the replacement fluid feed pump tube and between the end connected to the blood returning tubing part or the blood drawing tubing part and the replacement fluid feed pump tube in the replacement fluid supplying tubing part, installed in the first planar panel, is a replacement fluid heating flow path, and at least one surface of the dialysate heating flow path and the replacement fluid heating flow path is in contact with a heater surface of the heating apparatus.

5. The blood purification system according to claim 3, wherein the dialysate feed pump, the replacement fluid feed pump, and the drainage feed pump are tubing pumps, and a plane of an orbit in which a roller revolves, and a planar part of the first planar panel are located at a generally right angle.

6. The blood purification system according to claim 3, wherein having a fixture for fixing a part on an inlet side and/or outlet side of any of the dialysate feed pump tube, the replacement fluid feed pump tube, and the drainage feed pump tube.

16. The blood purification system according to claim 1, wherein the first planar panel is an integral plastic molding or one in which plastic moldings are bonded and integrated.

7. A blood purification system comprising a blood purification tubing and a blood purification apparatus, wherein

the blood purification tubing has a blood drawing tubing part for feeding blood drawn from a patient to a blood purifier, a blood returning tubing part for returning blood in the blood purifier to the patient, a drainage tubing part for performing drainage from the blood purifier, and a replacement fluid supplying tubing part for supplying a replacement fluid to the blood drawing tubing part or the blood returning tubing part,

the drainage tubing part has a drainage storage container,

the replacement fluid supplying tubing part has a replacement fluid storage container,

the drainage tubing part and the replacement fluid supplying tubing part are each located to pass in a first planar panel and in a second planar panel,

the drainage storage container and the replacement fluid storage container are installed in the second planar panel,

flow paths connecting the first planar panel and the second planar panel, in the drainage tubing part and the replacement fluid supplying tubing part, are composed of a soft tube,

the blood purification apparatus has a scale for measuring the second planar panel, and

the soft tubes and location of the soft tubes are selected to satisfy the following formula (1) when a weight of the second planar panel, with the drainage storage container and the replacement fluid storage container being empty, is B, a value obtained by subtracting the weight B from a weight of the second planar panel, with a liquid having a weight W placed only in the drainage storage container, is Wf, and a value obtained by subtracting the weight B from a weight of the second planar panel, with a liquid having the weight W placed only in the replacement fluid storage container, is Wr, and when each weight of B, Wf, and Wr is obtained from a numerical value measured by the scale of the blood purification apparatus

|Wf−

Wr|/W≦

0.005 

 

(1).

8. The blood purification system according to claim 7, wherein

another container is located in the second planar panel, and

the weight B is weight when the two storage containers and the another container of the second planar panel are empty.

9. The blood purification system according to claim 8, wherein the another container is connected to the replacement fluid storage container.

10. The blood purification system according to claim 7, wherein a flow path for forming a dialysate supplying tubing part for supplying a dialysate to the blood purifier is formed in the first planar panel.

11. The blood purification system according to claim 7, wherein

one end side of the soft tube is connected at an end α

on the second planar panel, and the other end side is connected at an end β

on the first planar panel, and

the soft tube is located so that

when an axial direction in an arbitrary portion χ

in a longitudinal direction of the soft tube connecting the end α and

the end β

is a vector X,

a gravity direction is a vector G, and

a narrower angle formed by the vector X and the vector G is an angle θ

X,

at least one portion χ

in which the angle θ

X is 70°

to 110°

is present,

provided that the vector X is a direction from the second planar panel toward the first planar panel.

12. The blood purification system according to claim 7, wherein

the blood purification tubing further has a replacement fluid feed pump tube and a drainage feed pump tube,

the blood purification apparatus further has a replacement fluid feed pump and a drainage feed pump for squeezing the pump tubes for feeding,

in the replacement fluid supplying tubing part, the replacement fluid feed pump tube, a replacement fluid branch duct, and a replacement fluid supply blocking part are located in this order from a blood returning tubing part or blood drawing tubing part side on a tubing having one end side connected to the blood returning tubing part or the blood drawing tubing part and the other end side connected to a replacement fluid storage part, and the replacement fluid storage container is connected to the replacement fluid branch duct,

in the drainage tubing part, the drainage feed pump tube, a drainage branch duct, and a drainage blocking part are located in this order from a drainage outlet side of the blood purifier on a tubing having one end side connected to a drainage outlet of the blood purifier and the other end side open, and the drainage storage container is connected to the drainage branch duct,

the blood purification apparatus further has a replacement fluid supply blocking valve and a drainage blocking valve for blocking the blocking parts,

a flow path in a portion near the replacement fluid feed pump tube and between an end connected to the blood returning tubing part or the blood drawing tubing part and the replacement fluid feed pump tube, and a flow path in a portion near the replacement fluid feed pump tube and between the replacement fluid feed pump tube and an end on the side connected to the replacement fluid storage part, in the replacement fluid supplying tubing part, and

a flow path in a portion near the drainage feed pump tube and between the drainage outlet of the blood purifier and the drainage feed pump tube, and a flow path in a portion near the drainage feed pump tube and between the drainage feed pump tube and an open end, in the drainage tubing part

are installed in the first planar panel,

the replacement fluid feed pump tube and the drainage feed pump tube are connected to the first planar panel, and

the replacement fluid branch duct and the drainage branch duct are installed in the first planar panel or the second planar panel.

13. The blood purification system according to claim 12, wherein

the blood purification apparatus has a heating apparatus,

the flow path in the portion near the replacement fluid feed pump tube and between the end connected to the blood returning tubing part or the blood drawing tubing part and the replacement fluid feed pump tube in the replacement fluid supplying tubing part, installed in the first planar panel, is a replacement fluid heating flow path, and at least one surface of the replacement fluid heating flow path is in contact with a heater surface of the heating apparatus.

14. The blood purification system according to claim 12, wherein the replacement fluid feed pump and the drainage feed pump are tubing pumps, and a plane of an orbit in which a roller revolves, and a planar part of the first planar panel are located at a generally right angle.

15. The blood purification system according to claim 12, wherein having a fixture for fixing a part on an inlet side and/or outlet side of any of the replacement fluid feed pump tube and the drainage feed pump tube.