Expandable medical device with beneficial agent in openings

• US 8,202,313 B2
• Filed: 05/19/2004
• Issued: 06/19/2012
• Est. Priority Date: 10/16/2000
• Status: Active Grant

• Current Assignee: Microport Cardiovascular LLC (MicroPort Scientific Corp.)
• Original Assignee: Innovational Holdings, LLC (Johnson & Johnson)
• Inventors: Shanley, John F., Eigler, Neal L., Edelman, Elazer R.
• Primary Examiner(s): Willse, David H
• Assistant Examiner(s): Blanco, Javier
• Application Number:
  US10/849,324
• Publication Number:
  US 20040220661A1
• Time in Patent Office: 2,953 Days
• Field of Search: 623/1.39, 623/1.42
• US Class Current: 623/1.16
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2250/0004 adjustable
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir

Abstract

An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together by ductile hinges to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. The plurality of struts and ductile hinges are arranged to improve the spatial distribution of the struts which is particularly important when delivering beneficial agents with the struts. The improved strut arrangement expands to a substantially parallelogram shape for improved beneficial agent distribution to the surrounding tissue. A beneficial agent may be loaded into openings within the struts or coated onto the struts for delivery to the tissue.

Claims

1. An expandable medical device comprising:

a plurality of substantially cylindrical tissue supporting bodies which are each expandable from a cylinder having a first diameter to a cylinder having a second diameter;

a plurality of flexible bridging members connecting the substantially cylindrical tissue supporting bodies to form an expandable device; and

a plurality of openings formed in the flexible bridging members, the openings containing a beneficial agent for delivery to tissue, wherein the plurality of openings in the flexible bridging members are substantially undeformed during flexing of the bridging members.

2. The device of claim 1, wherein the substantially cylindrical tissue supporting bodies and the plurality of flexible bridging members are formed from a tube.

3. The device of claim 2, wherein the substantially cylindrical tissue supporting bodies are formed from a plurality of struts.

4. The device of claim 1, further comprising a plurality of second openings formed in the substantially cylindrical tissue supporting bodies, the second openings containing a beneficial agent for delivery to tissue.

5. The device of claim 1, wherein the plurality of flexible bridging members are configured such that a total length of the flexible bridging members remains substantially constant during radial expansion.

6. The device of claim 1, wherein portions of the plurality of flexible bridging members are configured to remain substantially parallel during expansion.

7. The device of claim 1, wherein the expandable medical device is configured for radial expansion while an overall length of the device remains substantially constant.

8. The device of claim 1, wherein the openings are formed as recesses in the plurality of flexible bridging members.

9. The device of claim 1, wherein the openings are through openings extending through the plurality of flexible bridging members in a radial direction.

10. The device of claim 9, wherein the openings are formed by laser drilling.

11. The device of claim 1, wherein the plurality of flexible bridging members include at least one flexible portion and at least one opening containing portion, and wherein a width of the opening containing portion is greater than a width of the flexible portion.

12. The device of claim 11, wherein the opening containing portions are substantially undeformed when the plurality of cylindrical tissue supporting bodies are expanded.

13. The device of claim 11, wherein the plurality of openings have a largest dimension which is greater than the width of the at least one flexible portion.

14. The device of claim 1, wherein the plurality of openings each have an area of at least 5×

10<sup>−

6</sup> square inches.

15. An expandable medical device comprising:

a plurality of substantially cylindrical tissue supporting bodies which are each expandable from a cylinder having a first diameter to a cylinder having a second diameter;

a plurality of flexible bridging members connecting the substantially cylindrical tissue supporting bodies to form an expandable device;

a plurality of openings formed in the flexible bridging members, the openings containing a beneficial agent for delivery to tissue, wherein the plurality of flexible bridging members include at least one flexible portion and at least one opening containing portion, wherein a width of the opening containing portion is greater than a width of the flexible portion, and wherein the plurality of openings have a largest dimension which is greater than the width of the at least one flexible portion.

16. The device of claim 15, wherein the opening containing portions are substantially undeformed when the plurality of cylindrical tissue supporting bodies are expanded.

17. The device of claim 15, wherein the openings are formed by laser drilling.

18. The device of claim 15, wherein the openings are formed as recesses in the plurality of flexible bridging members.

19. The device of claim 15, wherein the openings are through openings extending through the plurality of flexible bridging members in a radial direction.

20. The device of claim 15, wherein the plurality of openings each have an area of at least 5×

10<sup>−

6</sup> square inches.