Implantable medical devices with elastomeric block copolymer coatings

• US 8,202,528 B2
• Filed: 06/05/2007
• Issued: 06/19/2012
• Est. Priority Date: 06/05/2007
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Wang, Yunbing, Castro, Daniel
• Primary Examiner(s): Sajjadi, Fereydoun G
• Assistant Examiner(s): HAGOPIAN, CASEY SHEA
• Application Number:
  US11/810,627
• Publication Number:
  US 20080306591A1
• Time in Patent Office: 1,841 Days
• Field of Search: None
• US Class Current: 424/422
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Implantable medical devices with elastomeric block copolymer coatings are disclosed.

Claims

1. An implantable medical device comprising a coating above a polymer surface of the device, the coating comprising:

a block copolymer including an elastic block and an anchor block, the elastic block being a random or alternating copolymer and having elastomeric behavior at physiological conditions, the anchor block being miscible with the surface polymer, wherein the surface polymer and the anchor block comprise PLLA or LPLG and wherein the block copolymer is selected from the group consisting of P(GA-co-CL)-b-PLLA, P(GA-co-CL)-b-LPLG, P(GA-co-TMC)-b-PLLA, and P(GA-co-TMC)-b-LPLG.

2. The device of claim 1, wherein the device is a stent.

3. The device of claim 1, wherein the block copolymer is bioabsorbable.

4. The device of claim 1, wherein a body of the device is formed from a bioabsorbable polymer.

5. The device of claim 1, wherein a majority of the coating comprises the block copolymer.

6. The device of claim 1, wherein the polymer surface comprises a surface of the substrate of the device.

7. The device of claim 1, wherein the polymer surface comprises a surface of a coating layer above a substrate of the device.

8. The device of claim 1, wherein the coating comprises an active agent.

9. The device of claim 1, wherein the elastic block, anchor block, and the surface polymer are biodegradable, wherein the elastic block is faster degrading than the anchor block and the surface polymer.

10. The device of claim 1, wherein the anchor block is of the same chemical composition as the surface polymer.

11. The device of claim 1, wherein the elastic block has a Tg below body temperature, and wherein the anchor block and the surface polymer have a Tg above body temperature.

12. The device of claim 1, wherein coating comprises an interfacial region between the surface polymer and the coating in which anchor blocks are mixed with the surface polymer.

13. The device of claim 1, wherein anchor blocks enhance adhesion of the coating to the polymer surface.