Implantable drug delivery devices having alternating hydrophilic and amphiphilic polymer layers
First Claim
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1. An implantable medical device comprising:
- a device body; and
a soluble coating comprising,a primer layer disposed over the device body, wherein the primer layer comprises either a hydrophilic polymer or an amphiphilic polymer;
a reservoir layer disposed over the primer layer, wherein if the primer layer comprises a hydrophilic polymer the reservoir layer comprises an amphiphilic polymer or alternatively if the primer layer comprises an amphiphilic polymer the reservoir layer comprises a hydrophilic polymer; and
a layer disposed over the reservoir layer, wherein if the reservoir layer comprises a hydrophilic polymer the layer disposed over the reservoir layer comprises an amphiphilic polymer or alternatively if the reservoir layer comprises an amphiphilic polymer the layer disposed over the reservoir layer comprises a hydrophilic polymer,wherein the soluble coating solvates completely within about 30 days after deployment of the implantable medical device; and
wherein the one or more hydrophilic polymers are independently selected from the group consisting of polyvinylpyrrolidone, poly(carboxymethyl cellulose) and poly[N-(2-hydroxypropyl)methacrylamide].
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Abstract
An implantable drug delivery medical device with alternating hydrophilic and amphiphilic polymer layers and methods of using for the treatment of vascular disease are disclosed.
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Citations
21 Claims
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1. An implantable medical device comprising:
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a device body; and a soluble coating comprising, a primer layer disposed over the device body, wherein the primer layer comprises either a hydrophilic polymer or an amphiphilic polymer; a reservoir layer disposed over the primer layer, wherein if the primer layer comprises a hydrophilic polymer the reservoir layer comprises an amphiphilic polymer or alternatively if the primer layer comprises an amphiphilic polymer the reservoir layer comprises a hydrophilic polymer; and a layer disposed over the reservoir layer, wherein if the reservoir layer comprises a hydrophilic polymer the layer disposed over the reservoir layer comprises an amphiphilic polymer or alternatively if the reservoir layer comprises an amphiphilic polymer the layer disposed over the reservoir layer comprises a hydrophilic polymer, wherein the soluble coating solvates completely within about 30 days after deployment of the implantable medical device; and wherein the one or more hydrophilic polymers are independently selected from the group consisting of polyvinylpyrrolidone, poly(carboxymethyl cellulose) and poly[N-(2-hydroxypropyl)methacrylamide]. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 16)
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11. An implantable medical device comprising:
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a device body; and a soluble coating comprising, a primer layer disposed over the device body, wherein the primer layer comprises either a hydrophilic polymer or an amphiphilic polymer; a reservoir layer disposed over the primer layer, wherein if the primer layer comprises a hydrophilic polymer the reservoir layer comprises an amphiphilic polymer or alternatively if the primer layer comprises an amphiphilic polymer the reservoir layer comprises a hydrophilic polymer; and a layer disposed over the reservoir layer, wherein if the reservoir layer comprises a hydrophilic polymer the layer disposed over the reservoir layer comprises an amphiphilic polymer or alternatively if the reservoir layer comprises an amphiphilic polymer the layer disposed over the reservoir layer comprises a hydrophilic polymer; wherein the soluble coating solvates completely within about 30 days after deployment of the implantable medical device; and wherein the one or more amphiphilic polymers are independently selected from the group consisting of poly(n-butyl methacrylate-phosphorylcholine), poly(ester amide)-phosphorylcholine, polylactide-phosphorylcholine, polyethylene glycol-poly(caprolactone)-di- or tri-blocks, polyethylene glycol-polylactide di- or tri-blocks and polyethylene glycol-poly(lactide-glycolide) di- or tri-blocks. - View Dependent Claims (12, 13, 14, 21)
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17. A soluble implantable medical device composed of alternating layers of hydrophilic and amphiphilic polymers and optionally one or more bioactive agents;
wherein the one or more hydrophilic polymers are independently selected from the group consisting of polyvinylpyrrolidone, poly(carboxymethyl cellulose) and poly[N-(2-hydroxypropyl)-methacrylamide]. - View Dependent Claims (18, 19, 20)
Specification