Compounds and compositions as protein kinase inhibitors

• US 8,202,876 B2
• Filed: 09/24/2007
• Issued: 06/19/2012
• Est. Priority Date: 10/02/2006
• Status: Expired due to Fees

• Current Assignee: Novartis Ag
• Original Assignee: IRM LLC, Novartis Ag
• Inventors: Albaugh, Pamela, Chopiuk, Gregory B., Ding, Qiang, Huang, Shenlin, Liu, Zuosheng, Pan, Shifeng, Ren, Pingda, Wang, Xia, Wang, Xing, Xie, Yongping, Zhang, Chengzhi, Zhang, Qiong, Zhang, Guobao, Poon, Daniel, Renhowe, Paul, Sendzik, Martin
• Primary Examiner(s): Padmanabhan, Sreeni
• Assistant Examiner(s): Pihonak, Sarah
• Application Number:
  US12/444,129
• Publication Number:
  US 20100029605A1
• Time in Patent Office: 1,730 Days
• Field of Search: 514/256, 514/406, 544/333, 548/364.1
• US Class Current: 514/256
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 21/02 Muscle relaxants, e.g. for tetanus or cramps
• CPC Class Codes: A61P 21/04 for myasthenia gravis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 33/06 Antimalarials
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 35/04 specific for metastasis
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 39/02 : Antidotes
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/14 : of the thyroid hormones, e.g. T3, T4
• CPC Class Codes: A61P 7/02 : Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 : Antihypertensives
• CPC Class Codes: A61P 9/14 : Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
• CPC Class Codes: C07D 401/14 : containing three or more hetero rings
• CPC Class Codes: C07D 403/04 : directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 403/14 : containing three or more hetero rings
• CPC Class Codes: C07D 405/14 : containing three or more hetero rings
• CPC Class Codes: C07D 417/14 : containing three or more hetero rings

Abstract

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.

Claims

1. A compound of Formula I:

2. The compound of claim 1 of Formula Ia:

3. The compound of claim 2 selected from Formula Ib, Ic and Id:

4. The compound of claim 3 in which R₃ is selected from hydrogen, methyl, morpholino-ethyl, ethoxy-carbonyl, chloro, trifluoromethyl, (methyl-piperidinyl)(methyl)amino-methyl, methyl-amino-carbonyl, hydroxy-methyl, dimethyl-amino-methyl, methyl-amino-methyl, morpholino-methyl, diethyl-amino-ethyl-amino-methyl, methyl-piperazinyl-methyl, methyl-piperazinyl-ethyl-amino-methyl, dimethyl-amino-propyl-amino-methyl, ((2-hydroxyethyl)(methyl)amino)methyl, ethyl-amino-methyl, trifluoromethyl-amino-methyl, dimethyl-amino-ethyl-amino-carbonyl, piperidinyl-ethyl-amino-carbonyl, morpholino-ethyl-amino-carbonyl, morpholino-carbonyl, amino-carbonyl, dimethyl-amino-carbonyl, dimethyl-amino-pyrrolidinyl-methyl, dimethyl-amino-pyrrolidinyl-carbonyl, thiomorpholino-methyl, methoxy-ethyl-piperazinyl-methyl, methoxy-ethyl-amino-carbonyl, cyano-methyl, (2,6-dimethylmorpholino)methyl, (2,6-dimethyl-piperidinyl)ethyl-amino-carbonyl and cyclopropyl-amino-carbonyl.

5. The compound of claim 4 in which R₁ is selected from morpholino-ethyl-amino, methyl-amino, methyl-piperazinyl-ethyl-amino, cyclopropyl-amino, hydroxy-ethyl-piperazinyl-amino, isopropyl-amino, dimethyl-amino-ethyl-amino, methyl-piperazinyl-amino, amino, 2,6-dimethyl-morpholino-ethyl-amino, hydroxy-pyridinyl-ethyl-amino, amino-ethyl-amino, 3-oxopiperazin-1-yl-ethyl-amino, hydroxy-ethyl-amino, hydroxy-propyl-amino, methyl-sulfanyl, methoxy, sulfanyl, pyridinyl-ethyl-amino, pyridinyl-methyl-amino, morpholino-methyl-pyridinyl-amino, carboxy-propyl-amino, carboxy-methyl-amino, azetidin-3-yl-amino, azetidin-3-yl-methyl-amino, carboxy-ethyl-amino and hydroxy-pyrrolidinyl.

6. The compound of claim 5 in which R₂ is selected from —

R₁₁, —

CONHR₁₁, SO₂NHR₁₁, —

NHR₁₁, —

NHC(O)R₁₁, —

NHS(O)_0-2R₁₁ and —

NHC(O)NHR₁₁;

wherein R₁₁ is selected from phenyl, pyridinyl, thiazolyl, benzimidazolyl, isoxazolyl, 1,2,3,4-tetrahydronaphthyl, benzothiazolyl, benzo[d][1,2,3]triazole, 2,3-dihydrobenzofuran and 2,3-dihydro-3,3-dimethylbenzofuran-5-yl;

wherein said phenyl, pyridinyl, thiazolyl, isoxazolyl and 2,3-dihydro-3,3-dimethylbenzofuran-5-yl of R₂ are optionally substituted with 1 to 3 radicals independently selected from halo, isopropyl, methyl-sulfonyl, hydroxy, methyl-sulfonyl-amino, 1-(2-hydroxyethylamino)cyclopropyl, 3-(3-hydroxypropylamino)cyclobutyl, isopropyl-amino-cyclobutyl, 2-(2-hydroxyethylamino)propan-2-yl, 3-aminoprop-1-enyl, isopropyl-3-aminoprop-1-enyl, isopropyl-amino-propyl, isopropyl-amino-ethyl, hydroxyethyl-3-aminoprop-1-enyl, methyl-amino, 1,2-dihydroxyethyl, 2-hydroxy-ethyl, (3-hydroxyazetidin-1-yl)methyl, (3-methoxyazetidin-1-yl)methyl, 2-methyl-morpholino-methyl, (3-methoxypyrrolidin-1-yl)methyl, (2-hydroxy-2-methylpropylamino)methyl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,2,3,6-tetrahydropyridin-4-yl, piperidin-4-yl, (4-ethylpiperazin-1-yl)methyl, pyrrolidiny-1-yl-methyl, 1-(ethylamino)ethyl, 4-( 2-hydroxypropyl)-1-piperazinyl, 3-trifluoromethyl-4-methyl-1-piperazinyl, difluoro-methyl, 4-methyl-1-imidazolyl, methyl-sulfonyl-ethyl-amino-carbonyl, hydroxy-propyl-amino-carbonyl, 4-t-butoxy-carbonyl-1-piperazinyl, 4-(1-carboxyethyl)piperazin-1-yl, 4,7-diazaspiro[2.5]octan-7-yl, ethoxy, 4-(tert-butoxycarbonyl)-2-oxopiperazin-1-yl, 4-methyl-2-oxopiperazin-1-yl, 2-oxopiperazin-1-yl, methoxy, ethyl, pyrazolyl, trifluoromethyl, 2-cyanobutan-2-yl, 1-cyanocyclopropyl, 2-hydroxypropan-2-yl, difluoromethyl, 3-ethylpentan-3-yl, methyl-piperazinyl, ethyl-piperazinyl, t-butyl, t-butoxy, 1,2-dihydroxypropyl, 2-hydroxymethyl-ethyl, cyclopropyl-1-piperazinyl, 4-methyl-sulfonyl-ethyl-1-piperazinyl, 2-hydroxy-propyl-amino-methyl, (tetrahydrofuran-2-ylamino)methyl, (2,3-dihydroxypropylamino)methyl), (1,3-dihydroxypropan-2-ylamino)methyl, (1-hydroxy-2-methylpropan-2-ylamino)methyl, cyclobutyl-amino-methyl, 4-hydroxy-piperidinyl, (1-hydroxypropan-2-ylamino)methyl, dimethyl-amino-amino-methyl, methoxy-amino-methyl, hydroxy-amino-methyl, 2-hydroxy-methyl-pyrrolidin-1-yl-methyl, pyrrolidinyl-ethoxy, 3-hydroxy-pyrrolidinyl, 3-hydroxyazetidin-1-yl, 3-(methoxy-carbonyl)-4-methylpiperazin-1-yl, 4-methylpiperazin-1-yl, 4-methyl-3-hydroxymethyl-piperazin-1-yl, 4-methoxy-carbonyl-piperidinyl, 4-carboxy-piperidinyl, piperazinyl, 4-(2,2,2-trifluoroethyl)piperazin-1-yl, 2-hydroxy-cyclopent-1-yl-amino-methyl, amino-carbonyl-methyl, dimethyl-amino-propyl(methyl)-amino, (2-(dimethylamino)ethyl)(methyl)amino, methoxy-ethyl(methyl)amino, dimethyl-amino-ethoxy, nitro, 1-methyl-4-piperidinyloxy, morpholino, 2-methyl-morpholino, 4-ethyl-piperazin-1-yl-methyl, ethyl-amino-methyl, cyclopropyl-amino-methyl, diethyl-amino-ethyl, azetidin-1-ylmethyl, 3-hydroxy-pyrrolidin-1-yl-methyl, hydroxy-ethyl-amino-methyl, propyl-amino-methyl, 3-hydroxy-azetidin-1-ylmethyl, 4-methoxyethyl-1-piperazinyl, methoxy-ethyl-amino-methyl, butyl-amino-ethyl, t-butyl-amino-methyl, hydroxy-cyclohexyl-amino-methyl, amino-methyl, hydroxy-propyl-amino-methyl, hydroxy-ethyl(methyl)amino-methyl, 4-hydroxypropyl-1-piperazinyl, 4-carboxy-methyl-piperazinyl, dimethyl-amino-methyl, isopropyl-amino-methyl, 4-dimethyl-amino-carbonyl-methyl-1-piperazinyl, 4-(2-hydroxypropyl)piperazin-1-yl, hydroxy-ethyl-piperazinyl, methyl, cyclopropyl, halo, trifluoromethoxy, difluoromethoxy, 2-fluoropropan-2-yl, 2-methoxy-propan-2-yl, 1,1-difluoroethyl, 1-methyl-1-fluoroethyl, 1-methyl-1-methoxy-ethyl, 2-hydroxypropan-2-yl, 2-methoxypropan-2-yl, 2-cyanopropan-2-yl, 3-cyanopropan-2-yl, 2,3-difluoropropan-2-yl and cyano-cyclopropyl.

7. The compound of claim 1 selected from N-(4-Methyl-3-{2-methyl-4-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, N-(4-Methyl-3-{1-methyl-4-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-1H-pyrazol-3-ylamino}1-phenyl)-3-trifluoromethyl-benzamide, N-(4-Methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, N-{4-Methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide, N-(4-Methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, N-[4-Methyl-3-(5-methyl-2-{6-[2-(4-methyl-piperazin-1-yl)-ethylamino]-pyrimidin-4-yl}-2H-pyrazol-3-ylamino)-phenyl]-3-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-{3-[4(6-Cyclopropylamino-pyrimidin-4-yl)-2-methyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-[4-Methyl-3-(2-methyl-4-{6-[2-(4-methyl-piperazin-1-yl)-ethylamino]-pyrimidin-4-yl}-2H-pyrazol-3-ylamino)-phenyl]-3-trifluoromethyl-benzamide, N-(4-Methyl-3-{2-methyl-4-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, N-{3-[4-(6-Cyclopropylamino-pyrimidin-4-yl)-1-methyl-1H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-[4-Methyl-3-(1-methyl-4-{6-[2-(4-methyl-piperazin-1-yl)-ethylamino]-pyrimidin-4-yl}-1H-pyrazol-3-ylamino)-phenyl]-3-trifluoromethyl-benzamide, N-(4-Methyl-3-{1-methyl-4-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-1H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide, N-{4-Methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-(4-ethyl-piperazin-1-yl)-5-trifluoromethyl-benzamide, 3-(4-Ethyl-piperazin-1-yl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-5-trifluoromethyl-benzamide, 3-(4-Ethyl-piperazin-1-yl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-5-trifluoromethyl-benzamide, N-(4-Methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide, N-{4-Methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide, 3-(4-Ethyl-piperazin-1-yl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-5-trifluoromethyl-benzamide, N-(4-Methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, 5-Methyl-6-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide, 5-Methyl-6-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide, 5-Methyl-6-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide, N-(4-Methyl-3-{2-[6-2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-{3-[2-(6-Amino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide, N-[3-(2-{6-[2-(2,6-Dimethyl-morpholin-4-yl)-ethylamino]-pyrimidin-4-yl}-5-methyl-2H-pyrazol-3-ylamino)-4-methyl-phenyl]-3-trifluoromethyl-benzamide, N-[3-(2-{6-[2-(4-Hydroxy-piperidin-1-yl)-ethylamino]-pyrimidin-4-yl}-5-methyl-2H-pyrazol-3-ylamino)-4-methyl-phenyl]-3-trifluoromethyl-benzamide, N-[4-Methyl-3-(5-methyl-2-{6-[2(4-oxo-piperazin-1-yl)-ethylamino]-pyrimidin-4-yl}-2H-pyrazol-3-ylamino)-phenyl]-3-trifluoromethyl-benzamide, N-(3-{2-[6-(2-Amino-ethylamino)-pyrimidin-4-yl]-5-methyl-2H-pyrazol-3-ylamino}-4-methyl-phenyl)-3-trifluoromethyl-benzamide, 2-tert-Butyl-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-tert-Butyl-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, N-{4-Methyl-3-[4-(6-methylamino-pyrimidin-4-yl)-1H-pyrazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide, N-{4-Methyl-3-[4-(6-methylamino-pyrimidin-4-yl)-1-(2-morpholin-4-yl-ethyl)-1H-pyrazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide, N-{4-Methyl-3-[1-methyl-4-(6-methylamino-pyrimidin-4-yl)-1H-pyrazol-3-ylamino]-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide, 3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-N-{4-methyl-3-[1-methyl-4-(6-methylamino-pyrimidin-4-yl)-1H-pyrazol-3-ylamino]-phenyl}-5-trifluoromethyl-benzamide, N-{3-[4-6-Cyclopropylamino-pyrimidin-4-yl)-1-methyl-1H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide, N-{3-[4-(6-Cyclopropylamino-pyrimidin-4-yl)-1-methyl-1H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-5-trifluoromethyl-benzamide, N-(3-{2-[6-(2-Hydroxy-ethylamino)-pyrimidin-4-yl]-5-methyl-2H-pyrazol-3-ylamino}-4-methyl-phenyl)-3-trifluoromethyl-benzamide, N-{4-Methyl-3-[5-methyl-2-(6-methylsulfanyl-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide, N-{3-[2-(2,3-Dihydro-imidazo[1,2-c]pyrimidin-7-yl)-5-methyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, 2-tert-Butyl-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, N-{3-[2-(6-Methoxy-pyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino]-4-methyl-phen-yl}-3-trifluoromethyl-benzamide, N-{4-Methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide, N-{3-[2-(6-Amino-pyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-{4-Methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide, N-{3-[2-(6-Mercapto-pyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-(4-Methyl-3-{5-methyl-2-[6-2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, 4-(6-{3-Methyl-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-pyrazol-1-yl}-pyrimidin-4-ylamino)-butyric acid, (6-{3-Methyl-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-pyrazol-1-yl}-pyrimidin-4-ylamino)-acetic acid, N-(3-{2-[6-(Azetidin-3-ylamino)-pyrimidin-4-yl]-5-methyl-2H-pyrazol-3-ylamino}-4-methyl-phenyl)-3-trifluoromethyl-benzamide, 3-(6-{3-Methyl-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-pyrazol-1-yl}-pyrimidin-4-ylamino)-propionic acid, N-(3-{2-[6-(3-Hydroxy-pyrrolidin-1-yl)-pyrimidin-4-yl]-5-methyl-2H-pyrazol-3-ylamino}-4-methyl-phenyl)-3-trifluoromethyl-benzamide, N-[3-(2-{6-[(Azetidin-3-ylmethyl)-amino]-pyrimidin-4-yl}-5-methyl-2H-pyrazol-3-ylamino)-4-methyl-phenyl]-3-trifluoromethyl-benzamide, N-[4-Methyl-3-(5-methyl-2-{6-[(pyridin-2-ylmethyl)-amino]-pyrimidin-4-yl}-2H-pyrazol-3-ylamino)-phenyl]-3-trifluoromethyl-benzamide, 4-Methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-N-[3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-phenyl]-benzamide, 5-Methyl-N-(4-methyl-3-{5-methyl-2-[6-(5-morpholin-4-ylmethyl-pyridin-2-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 3-Cyclopropyl-isoxazole-5-carboxylic acid (4-methyl-3-{5-methyl-2-[6-(5-morpholin-4-ylmethyl-pyridin-2-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-amide, 3,4-Dichloro-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-Fluoro-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-5-trifluoromethyl-benzamide, N-(4-Methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-4-trifluoromethyl-benzamide, 3,5-Dichloro-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 4-Fluoro-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, N-(4-Methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethoxy-benzamide, 3-Bromo-4-chloro-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-Difluoromethoxy-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-Chloro-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-(1-Hydroxy-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-(1-Methoxy-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 2-(Cyano-dimethyl-methyl)-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 3-(Cyano-dimethyl-methyl)-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-(1,1-Difluoro-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-(1-Cyano-cyclopropyl)-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3,3-Dimethyl-2,3-dihydro-benzofuran-5-carboxylic acid (4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-amide, 4-Methyl-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, 2-(Cyano-dimethyl-methyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 3-(Cyano-dimethyl-methyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-(1-Cyano-cyclopropyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 2-(1-Cyano-cyclopropyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 3-(1,1-Difluoro-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-(1-Hydroxy-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-(1-Methoxy-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 1-(6-Cyclopropylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid ethyl ester, 1-(6-Cyclopropylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid methylamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-hydroxymethyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-dimethylaminomethyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-methylaminomethyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-(3-{2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-[(2-diethylamino-ethylamino)-methyl]-2H-pyrazol-3-ylamino}-4-methyl-phenyl)-3-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-(4-methyl-piperazin-1-ylmethyl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-1(3-dimethylamino-propylamino)-methyl]-2H-pyrazol-3-ylamino}-4-methyl-phenyl)-3-trifluoromethyl-benzamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-ethylaminomethyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-(3-{2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-[(2,2,2-trifluoro-ethylamino)-methyl]-2H-pyrazol-3-ylamino}-4-methyl-phenyl)-3-trifluoromethyl-benzamide, 1-(6-Cyclopropylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid (2-dimethylamino-ethyl)-amide, 1-(6-Cyclopropylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid (2-piperidin-1-yl-ethyl)-amide, 1-(6-Cyclopropylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-(morpholine-4-carbonyl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, 1-(6-Cyclopropylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid amide, 1-(6-Cyclopropylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid dimethylamide, N-{3-[2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-(3-dimethylamino-pyrrolidine-1-carbonyl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, 1-(6-Cyclopropylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid (2-methoxy-ethyl)-amide, 1-(6-Methylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid methylamide, N-{4-Methyl-3-[5-methylaminomethyl-2-(6-methyl amino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide, N-{4-Methyl-3-[2-(6-methyl amino-pyrimidin-4-yl)-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide, 1-(6-Methylamino-pyrimidin-4-yl)-5-{2-methyl-5-[3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzoylamino]-phenylamino}-1H-pyrazole-3-carboxylic acid methylamide, 1-(6-Methylamino-2-morpholin-4-yl-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(1,1-Difluoro-ethyl)-benzoylamino]-2-methyl-phenylamino}-1-(6-methylamino-pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(Cyano-dimethyl-methyl)-benzoylamino]-2-methyl-phenylamino}-1-(6-methylamino-pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(1-Cyano-cyclopropyl)-benzoylamino]-2-methyl-phenylamino}-1-(6-methylamino-pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid methylamide, N-{3-[5-Cyanomethyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, 1-(6-Methylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide, 1-(6-Methylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid cyclopropylamide, 5-tert-Butyl-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 5-tert-Butyl-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 5-tert-Butyl-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, N-[5-(1-Fluoro-1-methyl-ethyl)-pyridin-3-yl]-4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-benzamide, N-[5-(1-Methoxy-1-methyl-ethyl)-pyridin-3-yl]-4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-benzamide, N-[5-(1-Fluoro-1-methyl-ethyl)-pyridin-3-yl]-4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-benzamide, N-[5-(1-Methoxy-1-methyl-ethyl)-pyridin-3-yl]-4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-benzamide, 4-Methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-N-(4-trifluoromethyl-pyridin-2-yl)-benzamide, N-(3-tert-Butyl-phenyl)-4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-benzamide, N-(2-tert-Butyl-pyridin-4-yl)-4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-benzamide, N-(3-tert-Butyl-phenyl)-4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-benzamide, N-[3-(Cyano-dimethyl-methyl)-phenyl]-4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-benzamide, 4-Methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-N-(4-trifluoromethyl-pyridin-2-yl)-benzamide, (6-{5-[5-(6-tert-Butyl-1H-benzoimidazol-2-yl)-2-methyl-phenylamino]-3-methyl-pyrazol-1-yl}-pyrimidin-4-yl)-(4-methyl-piperazin-1-yl)-amine, (6-{3-Methyl-5-[2-methyl-5-(6-trifluoromethyl-1H-benzoimidazol-2-yl)-phenylamino]-pyrazol-1-yl}-pyrimidin-4-yl)-(4-methyl-piperazin-1-yl)-amine, N-[3-(1,1-Difluoro-ethyl)-phenyl]-4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-benzamide, N-[3-(1,1-Difluoro-ethyl)-phenyl]-4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-benzamide, 4-Fluoro-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide, 4-Fluoro-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, 5-[5-(4-Fluoro-3-trifluoromethyl-benzoylamino)-2-methyl-phenylamino]-1-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 5-[5-(4-Fluoro-3-trifluoromethyl-benzoylamino)-2-methyl-phenylamino]-1-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 5-[5-(4-Fluoro-3-trifluoromethyl-benzoylamino)-2-methyl-phenylamino]-1-(6-methylamino-pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide, 5-[5-(2-tert-Butyl-pyridin-4-ylcarbamoyl)-2-methyl-phenylamino]-1-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(1,1-Difluoro-ethyl)-benzoylamino]-2-methyl-phenylamino}-1-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide, N-(4-Methyl-3-{2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, 3-(1,1-Difluoro-ethyl)-N-(4-methyl-3-{2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-(Cyano-dimethyl-methyl)-N-(4-methyl-3-{2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 2-tert-Butyl-N-(4-methyl-3-{2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 5-tert-Butyl-N-(4-methyl-3-{2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 2-(Cyano-dimethyl-methyl)-N-(4-methyl-3-{2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-(Cyano-dimethyl-methyl)-N-{3-[5-{[(2-hydroxy-ethyl)-methyl-amino]-methyl}-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-isonicotinamide, 3-(Cyano-dimethyl-methyl)-N-{3-[5-{[(2-hydroxy-ethyl)-methyl-amino]-methyl}-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-benzamide, 2-tert-Butyl-N-{3-[5-{[(2-hydroxy-ethyl)-methyl-amino]-methyl}-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-isonicotinamide, 2-tert-Butyl-N-{3-[5-[2-(2,6-dimethyl-piperidin-1-yl)-ethylcarbamoyl]-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-isonicotinamide, 2-(Cyano-dimethyl-methyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 3-(Cyano-dimethyl-methyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 3-(1-Cyano-cyclopropyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 2-(1-Cyano-cyclopropyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 3-(1-Cyano-1-methyl-propyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 2-tert-Butyl-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 3-(1,1-Difluoro-ethyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 3-(1-Hydroxy-1-methyl-ethyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 3-(1-Methoxy-1-methyl-ethyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 5-tert-Butyl-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-nicotinamide, 2-tert-Butyl-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2,2-Dimethyl-2,3-dihydro-benzofuran-7-carboxylic acid {4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-amide, 2-(1-Fluoro-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-sonicotinamide, 2-(1-Fluoro-1-methyl-ethyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-(1-Fluoro-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-(1-Methoxy-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-(1-Methoxy-ethyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-(1-Methoxy-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-(1-Hydroxy-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-(1-Hydroxy-1-methyl-ethyl)-N-{4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-(1-Hydroxy-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 3-(1-Cyano-cyclopropyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 3-(Cyano-dimethyl-methyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 2-(Cyano-dimethyl-methyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-(1-Cyano-cyclopropyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 3-(1,1-Difluoro-ethyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 3-(1-Methoxy-1-methyl-ethyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 3-(1-Hydroxy-1-methyl-ethyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-benzamide, 2-(1-Fluoro-1-methyl-ethyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-(1-Methoxy-1-methyl-ethyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-(1-Hydroxy-1-methyl-ethyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 5-tert-Butyl-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-nicotinamide, N-[3-(Cyano-dimethyl-methyl)-phenyl]-4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-benzamide, N-(2-tert-Butyl-pyridin-4-yl)-4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-benzamide, 5-(1-Fluoro-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 5-(1-Methoxy-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 5-(1-Hydroxy-1-methyl-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 2-(1,1-Difluoro-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, N-{3-[2-(6-Amino-pyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-(1,1-difluoro-ethyl)-benzamide, 3-(1,1-Difluoro-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(5-morpholin-4-ylmethyl-pyridin-2-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-(1,1-Difluoro-ethyl)-N-(4-methyl-3-{5-methyl-2-[6-(4-morpholin-4-ylmethyl-pyridin-2-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-benzamide, N-{3-[2-(6-Amino-pyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-2-tert-butyl-isonicotinamide, 2-tert-Butyl-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-tert-Butyl-N-[3-(2-{6-[4-(2-hydroxy-ethyl)-piperazin-1-ylamino]-pyrimidin-4-yl}-5-methyl-2H-pyrazol-3-ylamino)-4-methyl-phenyl]-isonicotinamide, 5-tert-Butyl-N-[3-(2-{6-[4-(2-hydroxy-ethyl)-piperazin-1-ylamino]-pyrimidin-4-yl}-5-methyl-2H-pyrazol-3-ylamino)-4-methyl-phenyl]-nicotinamide, N-(2-tert-Butyl-pyridin-4-yl)-3-(2-{6[4-(2-hydroxy-ethyl)-piperazin-1-ylamino]-pyrimidin-4-yl}-5-methyl-2H-pyrazol-3-ylamino)-4-methyl-benzamide, N-(5-tert-Butyl-pyridin-3-yl)-4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-benzamide, N-[2-(1-Methoxy-1-methyl-ethyl)-pyridin-4-yl]-4-methyl-3-{5-methyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-benzamide, N-[3-(1,1-Difluoro-ethyl)-phenyl]-4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-benzamide, N-[2-(Cyano-dimethyl-methyl)-pyridin-4-yl]-4-methyl-3-[5-methyl-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-benzamide, 5-(1-Fluoro-1-methyl-ethyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-phenyl}-nicotinamide, N-{3-[2-(6-Amino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-2-tert-butyl-isonicotinamide, 3-(1,1-Difluoro-ethyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino]-phenyl}-benzamide, N-[2-(1,1-Difluoro-ethyl)-pyridin-4-yl]-4-methyl-3-{5-methyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-benzamide, 5-{5-[3-(1,1-Difluoro-ethyl)-benzoylamino]-2-methyl-phenylamino}-1-(6-methylamino-pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide, 5-tert-Butyl-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-(2-morpholin-4-yl-ethylcarbamoyl)-2H-pyrazol-3-ylamino]-phenyl}-nicotinamide, 5-tert-Butyl-N-(4-methyl-3-{5-methylcarbamoyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 1-(6-Methylamino-pyrimidin-4-yl)-5-{2-methyl-5-[3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzoylamino]-phenylamino}-1H-pyrazole-3-carboxylic acid methylamide, 1-(6-Methylamino-2-morpholin-4-yl-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(1,1-Difluoro-ethyl)-benzoylamino]-2-methyl-phenylamino}-1-(6-methylamino-pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(Cyano-dimethyl-methyl)-benzoylamino]-2-methyl-phenylamino}-1-(6-methylamino-pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(1-Cyano-cyclopropyl)-benzoylamino]-2-methyl-phenylamino}-1-(6-methylamino-pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid methylamide, 1-(6-Methylamino-pyrimidin-4-yl)-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid cyclopropylamide, 2-(Cyano-dimethyl-methyl)-N-(4-methyl-3-{5-methylcarbamoyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-(Cyano-dimethyl-methyl)-N-(4-methyl-3-{5-methylcarbamoyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 5-{5-[3-(Cyano-dimethyl-methyl)-benzoylamino]-2-methyl-phenylamino}-1-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(Cyano-dimethyl-methyl)-benzoylamino]-2-methyl-phenylamino}-1-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 2-tert-Butyl-N-(4-methyl-3-{5-methylcarbamoyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-tert-Butyl-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-tert-Butyl-N-{4-methyl-3-[2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-(2-morpholin-4-yl-ethylcarbamoyl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-tert-Butyl-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-methylcarbamoyl-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-tert-Butyl-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-(2-morpholin-4-yl-ethylcarbamoyl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 5-[5-(3-tert-Butyl-benzoylamino)-2-methyl-phenylamino]-1-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 2-Chloro-6-methoxy-N-(4-methyl-3-{5-methylcarbamoyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-Chloro-6-methoxy-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 2-Chloro-6-methoxy-N-{4-methyl-3-[2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-(2-morpholin-4-yl-ethylcarbamoyl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-Chloro-6-methoxy-N-{4-methyl-3-[2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-(2-morpholin-4-yl-ethylcarbamoyl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-Chloro-6-methoxy-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-(2-morpholin-4-yl-ethylcarbamoyl)-2H-pyrazol-3-ylamino]-phenyl}-isonicotinamide, 2-Chloro-6-methoxy-N-(4-methyl-3-{5-methylcarbamoyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, N-(4-Methyl-3-{5-methylcarbamoyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-6-pyrazol-1-yl-nicotinamide, N-{4-Methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-methylcarbamoyl-2H-pyrazol-3-ylamino]-phenyl}-6-pyrazol-1-yl-nicotinamide, N-{4-Methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-(2-morpholin-4-yl-ethylcarbamoyl)-2H-pyrazol-3-ylamino]-phenyl}-6-pyrazol-1-yl-nicotinamide, N-(4-Methyl-3-{5-methylcarbamoyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-6-pyrazol-1-yl-nicotinamide, 5-[2-Methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, N-(4-Methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, 5-[2-Methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide, 1-[6-(4-Methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-5-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-1H-pyrazole-3-carboxylic acid methylamide, N-(4-Methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-6-trifluoromethoxy-nicotinamide, N-{4-Methyl-3-[2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-(2-morpholin-4-yl-ethylcarbamoyl)-2H-pyrazol-3-ylamino]-phenyl}-6-trifluoromethoxy-nicotinamide, N-{4-Methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-methylcarbamoyl-2H-pyrazol-3-ylamino]-phenyl}-6-trifluoromethoxy-nicotinamide, N-{4-Methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-(2-morpholin-4-yl-ethylcarbamoyl)-2H-pyrazol-3-ylamino]-phenyl}-6-trifluoromethoxy-nicotinamide, N-(4-Methyl-3-{5-methylcarbamoyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-6-trifluoromethoxy-nicotinamide, 2-(Cyano-dimethyl-methyl)-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 5-{5-[3-(1-Cyano-1-methyl-propyl)-benzoylamino]-2-methyl-phenylamino}-1-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 3-(1-Cyano-1-methyl-propyl)-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 5-{5-[3-(1-Cyano-1-methyl-propyl)-benzoylamino]-2-methyl-phenylamino}-1-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(1-Cyano-1-methyl-propyl)-benzoylamino]-2-methyl-phenylamino}-1-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(1-Methoxy-1-methyl-ethyl)-benzoylamino]-2-methyl-phenylamino}-1-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 3-(1-Methoxy-1-methyl-ethyl)-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 3-(Cyano-dimethyl-methyl)-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 5-tert-Butyl-N-(4-methyl-3-{5-methylcarbamoyl-2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 5-tert-Butyl-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 5-{5-[3-(1,1-Difluoro-ethyl)-benzoylamino]-2-methyl-phenylamino}-1-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-1H-pyrazole-3-carboxylic acid methylamide, 3-(1,1-Difluoro-ethyl)-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 5-{5-[3-(1,1-Difluoro-ethyl)-benzoylamino]-2-methyl-phenylamino}-1-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-1H-pyrazole-3 1H-pyrazole-3-carboxylic acid methylamide, 2-tert-Butyl-N-(4-methyl-3-{5-methylcarbamoyl-2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 4-tert-Butyl-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 4-tert-Butoxy-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide, 4-Methoxy-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethyl-benzamide, 3-tert-Butoxy-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide, N-(4-Methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-4-trifluoromethoxy-benzamide, N-(4-Methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-3-trifluoromethoxy-benzamide, 5-{5-[3-(1,1-Difluoro-ethyl)-benzoylamino]-2-methyl-phenylamino}-1-(6-methylamino-pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid methylamide, 5-{5-[3-(Cyano-dimethyl-methyl)-benzoylamino]-2-methyl-phenylamino}-1-(6-methylamino-pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide, 5-tert-Butyl-N-(4-methyl-3-{2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-nicotinamide, 2-tert-Butyl-N-(4-methyl-3-{2-[6-(4-methyl-piperazin-1-ylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-isonicotinamide, 5-tert-Butyl-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino]-phenyl}-nicotinamide, 1-Isopropyl-1H-benzotriazole-5-carboxylic acid {4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino]-phenyl}-amide, 5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid {4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino]-phenyl}-amide, 2-Methyl-benzothiazole-5-carboxylic acid {4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino]-phenyl}-amide, N-{3-[5-(3-Dimethylamino-pyrrolidin-1-ylmethyl)-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-{3-[5-(2,6-Dimethyl-morpholin-4-ylmethyl)-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-{3-[5-(2,6-Dimethyl-morpholin-4-ylmethyl)-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide, N-[4-Methyl-3-(2-(6-methylamino-pyrimidin-4-yl)-5-{[methyl-(1-methyl-piperidin-4-yl)-amino]-methyl}-2H-pyrazol-3-ylamino)-phenyl]-3-trifluoromethyl-benzamide, N-{3-[5-((1,1-dioxothiomorpholin-4-yl)methyl)-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide;

N-{4-Methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-thiomorpholin-4-ylmethyl-2H-pyrazol-3-ylamino]-phenyl}-3-trifluoromethyl-benzamide, 5-tert-butyl-N-(3-(3-(((2-hydroxyethyl)(methyl)amino)methyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-4-methylphenyl)nicotinamide, -(2-(2-fluoropropan-2-yl)pyridin-4-yl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, 5-tert-butyl-N-(3-(3-(((2-hydroxyethyl)(methyl)aminomethyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-4-methylphenyl)nicotinamide, 5-tert-butyl-N-(3-(3-(2-(2,6-dimethylpiperidin-1-yl)ethylcarbamoyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-4-methylphenyl)nicotinamide, 5-(2-methoxypropan-2-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)nicotinamide, 5-(2-fluoropropan-2-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)nicotinamide, N-(4-tert-butylthiazol-2-yl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(4-(2-fluoropropan-2-yl)pyridin-2-yl)-4-methyl-3-(3-methyl-1-(6-(4-methylpiperazin-1-ylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, 5-(5-(2-tert-butylpyridin-4-ylcarbamoyl)-2-methylphenylamino)-1-(6-(isopropylamino)pyrimidin-4-yl)-N-methyl-1H-pyrazole-3-carboxamide, 5-(5-(2-tert-butylpyridin-4-ylcarbamoyl)-2-methylphenylamino)-N-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazole-3-carboxamide, N-(2-tert-butylpyridin-4-yl)-4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-3-(morpholinomethyl)-1H-pyrazol-5-ylamino)benzamide, N-(2-tert-Butyl-pyridin-4-yl)-3-[5-((1,1-dioxothiomorpholin-4-yl)methyl)-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-benzamide, 2-tert-butyl-N-(3-(1-(6-(isopropylamino)pyrimidin-4-yl)-3-(methylcarbamoyl)-1H-pyrazol-5-ylamino)-4-methylphenyl)isonicotinamide, N-(2-tert-butylpyridin-4-yl)-3-(1-(6-(isopropylamino)pyrimidin-4-yl)-3-(morpholinomethyl)-1H-pyrazol-5-ylamino)-4-methylbenzamide, N-(2-tert-Butyl-pyridin-4-yl)-3-[5-((1,1-dioxothiomorpholin-4-yl)methyl)-2-(6-isopropylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-benzamide, 2-tert-butyl-N-(3-(1-(6-(isopropylamino)pyrimidin-4-yl)-3-(morpholinomethyl)-1H-pyrazol-5-ylamino)-4-methylphenyl)isonicotinamide, N-(4-(2-fluoropropan-2-yl)pyridin-2-yl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(5-tert-butyl-4-methylthiazol-2-yl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(5-tert-butyl-4-methylthiazol-2-yl)-4-methyl-3-(3-methyl-1-(6-(4-methylpiperazin-1-ylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(4-(2-cyanopropan-2-yl)pyridin-2-yl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(2-(2-methoxypropan-2-yl)pyridin-4-yl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(4-tert-butylthiazol-2-yl)-4-methyl-3-(3-methyl-1-(6-(2-morpholinoethylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(5-tert-butyl-4-methylthiazol-2-yl)-4-methyl-3-(3-methyl-1-(6-(2-morpholinoethylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, -(4-(1,1-difluoroethyl)pyridin-2-yl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(4-(1,1-difluoroethyl)pyridin-2-yl)-4-methyl-3-(3-methyl-1-(6-(4-methylpiperazin-1-ylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(4-tert-butylpyridin-2-yl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(4-tert-butylpyridin-2-yl)-4-methyl-3-(3-methyl-1-(6-(4-methylpiperazin-1-ylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, 3-(1-(6-aminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)-N-(5-tert-butyl-4-methylthiazol-2-yl)-4-methylbenzamide, 3-(1-(6-aminopyrimidin-4-yl)-1H-pyrazol-5-ylamino)-N-(4-tert-butylthiazol-2-yl)-4-methylbenzamide, N-(4-(2-methoxypropan-2-yl)pyridin-2-yl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(4-(2-methoxypropan-2-yl)pyridin-2-yl)-4-methyl-3-(3-methyl-1-(6-(4-methylpiperazin-1-ylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(6-methyl-5-(3-methyl-1-(6-(4-methylpiperazin-1-ylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)pyridin-3-yl)-3-(trifluoromethyl)benzamide, N-(6-methyl-5-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)pyridin-3-yl)-3-(trifluoromethyl)benzamide, 2-tert-butyl-N-(6-methyl-5-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)pyridin-3-yl)isonicotinamide, 2-tert-butyl-N-(6-methyl-5-(3-methyl-1-(6-(4-methylpiperazin-1-ylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)pyridin-3-yl)isonicotinamide, N-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-3-(1-oxo-thiomorpholinomethyl)-1H-pyrazol-5-ylamino)phenyl)-3-(trifluoromethyl)benzamide, N-(3-(1-(6-aminopyrimidin-4-yl)-3-methyl-1H-pyrazol-5-ylamino)-4-methylphenyl)-3-(4-hydroxypiperidin-1-yl)-5-(trifluoromethyl)benzamide, 3-(4-hydroxypiperidin-1-yl)-N-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(4-hydroxypiperidin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(4-(2-hydroxyethyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-morpholino-5-(trifluoromethyl)benzamide, (S)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(2-methylmorpholino)-5-(trifluoromethyl)benzamide, (R)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(2-methylmorpholino)-5-(trifluoromethyl)benzamide, 1-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(3-(trifluoromethyl)phenyl)urea, 1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 1-(3-(4-ethylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(1,1-dioxo-thiomorpholino)-5-(trifluoromethyl)benzamide, (R)-3-(3,4-dimethylpiperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (R)-3-(3,4-dimethylpiperazin-1-yl)-N-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(3-(4-hydroxypiperidin-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(3-(3-hydroxyazetidin-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, 2-(1,1-difluoroethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)isonicotinamide, N-(3-((2-methoxyethyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, 3-(1,1-difluoroethyl)-N-(3-(3-(hydroxymethyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-4-methylphenyl)benzamide, N-(3-(3-(hydroxymethyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-4-methylphenyl)-3-(4-hydroxypiperidin-1-yl)-5-(trifluoromethyl)benzamide, 4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-3-(trifluoromethyl)-1H-pyrazol-5-ylamino)-N-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)benzamide, N-(3-(3-(hydroxymethyl)-4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(3-((2-hydroxyethyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(3-(4-(hydroxymethyl)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, 1-(3-(1,1-difluoroethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 1-(2-(1,1-difluoroethyl)pyridin-4-yl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 1-(3-(4-hydroxypiperidin-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, N-(3-fluoro-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, 4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-N-(3-(methylsulfonamido)-5-(trifluoromethyl)phenyl)benzamide, 2-methoxy-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-6-(trifluoromethyl)isonicotinamide, 4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide, N-(4-chloro-3-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(4-fluoro-3-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-nitro-5-(trifluoromethyl)benzamide, 3-amino-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((2-methoxyethyl)(methyl)amino)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 1-(4-bromo-3-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(6-methyl-5-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)pyridin-3-yl)urea, 1-(3-(4-(2-hydroxyethyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(3-(hydroxymethyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-4-methylphenyl)urea, 3-hydroxy-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(1-(6-(2-(dimethylamino)ethylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazol-5-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide, 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(1-(6-(2-(dimethylamino)ethylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazol-5-ylamino)-4-methylphenyl)urea, 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(2-morpholinoethylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 3-(1-(6-(3-hydroxypropylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazol-5-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide, 3-(difluoromethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, 3-(difluoromethyl)-N-(3-(3-(hydroxymethyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-4-methylphenyl)benzamide, 1-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 3-(4-methyl-1H-imidazol-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide, N-(3-methoxy-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, 4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-N-(2-methyl-5-(trifluoromethyl)phenyl)benzamide, 1-(3-(1,1-difluoroethyl)phenyl)-3-(3-(3-(hydroxymethyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-4-methylphenyl)urea, 4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-N-(3-methyl-5-(trifluoromethyl)phenyl)benzamide, 1-(3-((2-methoxyethyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 1-(3-((2-(dimethylamino)ethyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-3-(morpholinomethyl)-1H-pyrazol-5-ylamino)phenyl)urea, 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(3-((dimethylamino)methyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-4-methylphenyl)urea, 3-bromo-5-(1,1-difluoroethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, (R)-1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-3-((2-methylmorpholino)methyl)-1H-pyrazol-5-ylamino)phenyl)urea, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(piperazin-1-yl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)-5-(trifluoromethyl)benzamide, 3-(4-(3-hydroxypropyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(4-(2-hydroxypropyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(4-cyclopropylpiperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(4,7-diazaspho[2.5]octan-7-yl)-5-(trifluoromethyl)benzamide, 2-ethoxy-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-6-(trifluoromethyl)isonicotinamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(trifluoromethyl)-5-(3-(trifluoromethyl)piperazin-1-yl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(4-methyl-4,7-diazaspho[2.5]octan-7-yl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-2-(methylamino)-6-(trifluoromethyl)isonicotinamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(4-methyl-3-(trifluoromethyl)piperazin-1-yl)-5-(trifluoromethyl)benzamide, 2-(2-hydroxyethylamino)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-6-(trifluoromethyl)isonicotinamide, 3-(4-hydroxypiperidin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (R)-3-(4-(2-hydroxypropyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (S)-3-(4-(2-hydroxypropyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(3-((4-ethylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, 4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-N-(3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)phenyl)benzamide, N-(3-((dimethylamino)methyl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide, 3-((dimethylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)benzamide, 3-((isopropylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-((methylamino)methyl)-5-(trifluoromethyl)benzamide, 1-(3-((dimethylamino)methyl)-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 1-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)phenyl)urea, 1-(3-((4-ethylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)urea, 3-((ethylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((cyclopropylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(1,1-difluoroethyl)-5-((isopropylamino)methyl)-N-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, 3-(1,1-difluoroethyl)-5-((isopropylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, 3-((diethylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(azetidin-1-ylmethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(azetidin-1-ylmethyl)-N-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((3-hydroxyazetidin-1-yl)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((3-hydroxypyrrolidin-1-yl)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((2-hydroxyethylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-((propylamino)methyl)-5-(trifluoromethyl)benzamide, 3-(1,1-difluoroethyl)-5-((dimethylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, 3-((cyclopropylamino)methyl)-5-(1,1-difluoroethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, 3-((3-hydroxypropylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(1,1-difluoroethyl)-5-((ethylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, 3-((2-methoxyethylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((butylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((tert-butylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(1,1-difluoroethyl)-5-((4-hydroxycyclohexylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, 3-((cyclopropylamino)methyl)-5-(1,1-difluoroethyl)-N-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, 3-(aminomethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 2-((dimethylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-6-(trifluoromethyl)isonicotinamide, 3-(((2-hydroxyethyl)(methyl)amino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(1,2-dihydroxyethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((1-hydroxypropan-2-ylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((1-hydroxypropan-2-ylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((2,2-dimethylhydrazinyl)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((methoxyamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((hydroxyamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (S)-3-((2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (S)-3-((2-hydroxypropylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (R)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(((tetrahydrofuran-2-yl)methylamino)methyl)-5-(trifluoromethyl)benzamide, (R)-3-((2,3-dihydroxypropylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (S)-3-((2,3-dihydroxypropylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((1,3-dihydroxypropan-2-ylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((l-hydroxy-2-methylpropan-2-ylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((cyclobutylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((dimethylamino)methyl)-N-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(((2-methoxyethyl)(methyl)amino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(((1S,2R)-2-hydroxycyclopentylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (S)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(((tetrahydrofuran-2-yl)methylamino)methyl)-5-(trifluoromethyl)benzamide, (R)-3-((2-hydroxypropylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(morpholinomethyl)-5-(trifluoromethyl)benzamide, 3-((3-methoxy azetidin-1-yl)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide 3-((3-methoxypyrrolidin-1-yl)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((3-hydroxyazetidin-1-yl)methyl)-N-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(4-chloro-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-((dimethylamino)methyl)-5-(trifluoromethyl)benzamide, N-(4-chloro-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-((isopropylamino)methyl)-5-(trifluoromethyl)benzamide, N-(4-chloro-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)benzamide, 3-((isopropylamino)methyl)-N-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)benzamide, 3-(1-(ethylamino)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (S)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-((2-methylmorpholino)methyl)-5-(trifluoromethyl)benzamide, (R)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-((2-methylmorpholino)methyl)-5-(trifluoromethyl)benzamide, 3-((2-hydroxy-2-methylpropylamino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)-5-(trifluoromethyl)benzamide, N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(piperidin-4-yl)-5-(trifluoromethyl)benzamide, 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(1,2-dihydroxyethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(1-hydroxyethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(3-(2-hydroxyethylamino)cyclobutyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(3-(isopropylamino)cyclobutyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (E)-3-(3-aminoprop-1-enyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (E)-3-(3-(isopropylamino)prop-1-enyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (E)-3-(3-(2-hydroxyethylamino)prop-1-enyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(3-(isopropylamino)propyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(2-(isopropylamino)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(2-(2-hydroxyethylamino)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(1-((2-hydroxyethyl)amino)cyclopropyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(2-((2-hydroxyethyl)amino)propan-2-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (S)-3-(1-(ethylamino)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (R)-3-(1-(ethylamino)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (R)-3-(1-(dimethylamino)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (S)-3-(1-(dimethylamino)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (S)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(1-(pyrrolidin-1-yl)ethyl)-5-(trifluoromethyl)benzamide, (R)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(1-(pyrrolidin-1-yl)ethyl)-5-(trifluoromethyl)benzamide, (S)-3-(1-(isopropylamino)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (R)-3-(1-(isopropylamino)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-(4-(2,2-difluoroethyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-chloro-5-(4-(2-methoxyethyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, 3-chloro-5-(4-(2-ethoxyethyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)benzamide, 3-chloro-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(4-methylpiperazin-1-yl)benzamide, (S)-3-(4-(2-methoxyethyl)-2-methylpiperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (R)-3-(4-(2-methoxyethyl)-2-methylpiperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (R)-3-(2,4-dimethylpiperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (S)-3-(2,4-dimethylpiperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((3,3-difluoroazetidin-1-yl)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((3,3-difluoropyrrolidin-1-yl)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, (R)-3-(4-(2,2-difluoroethyl)-2-methylpiperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, rac-3-(2-(3,3-difluoropyrrolidin-1-yl)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, rac-3-(2-(3,3-difluoroazetidin-1-yl)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, 3-((2,2-difluoroethyl)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide and 3-(((2,2-difluoroethyl)amino)methyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide.

8. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable excipient.

9. A compound selected from:

N-[3-(2-(6-Cyclopropylamino-pyrimidin-4-yl)-5-{[2-(4-methyl-piperazin-1-yl)-ethylamino]-methyl}-2H-pyrazol-3-ylamino)-4-methyl-phenyl]-3-trifluoromethyl-benzamide;

2-tert-Butyl-N-(3-{2-[6-(2-dimethylamino-acetylamino)-pyrimidin-4-yl]-2H-pyrazol-3-ylamino}-4-methyl-phenyl)-isonicotinamide;

4-Methanesulfonyl-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide;

4-Chloro-3-methanesulfonyl-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide;

3-Methanesulfonyl-N-(4-methyl-3-{2-[6-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yl]-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino}-phenyl)-benzamide;

3-(1,1-Diethyl-propyl)-N-{4-methyl-3-[2-(6-methylamino-pyrimidin-4-yl)-5-morpholin-4-ylmethyl-2H-pyrazol-3-ylamino]-phenyl}-benzamide;

N-{3-[5-[4-(2-Methoxy-ethyl)-piperazin-1-ylmethyl]-2-(6-methylamino-pyrimidin-4-yl)-2H-pyrazol-3-ylamino]-4-methyl-phenyl}-3-trifluoromethyl-benzamide;

N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(1-methylpiperidin-4-yloxy)-5-(trifluoromethyl)benzamide;

N-(3-(2-(dimethylamino)ethoxy)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide;

4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-N-(3-(2-(pyrrolidin-1-yl)ethoxy)-5-(trifluoromethyl)phenyl)benzamide;

methyl 1-methyl-4-(3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamido)-5-(trifluoromethyl)phenyl)piperazine-2-carboxylate;

N-(3-((2-(dimethylamino)ethyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide;

methyl 1-(3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamido)-5-(trifluoromethyl)phenyl)piperidine-4-carboxylate, 1-(3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamido)-5-(trifluoromethyl)phenyl)piperidine-4-carboxylic acid;

3-((3-(dimethylamino)propyl)(methyl)amino)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide;

3-((2-(dimethylamino)ethyl)(methyl)amino)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide;

methyl 3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamido)-5-(trifluoromethyl)benzoate;

3-(2-(dimethylamino)ethoxy)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide;

3-(3-(dimethylamino)propoxy)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide;

4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-N-(3-(2-(methylsulfonyl)ethylcarbamoyl)-5-(trifluoromethyl)phenyl)benzamide;

N-(3-(3-hydroxypropylcarbamoyl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)benzamide;

tert-butyl 4-(3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenylcarbamoyl)-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate;

3-(4-(2-amino-2-oxoethyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide;

3-(4-(2-methoxyethyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide;

2-(4-(3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenylcarbamoyl)-5-(trifluoromethyl)phenyl)piperazin-1-yl)acetic acid;

3-(4-(2-(dimethylamino)-2-oxoethyl)piperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide;

N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(4-(2-(methylsulfonyl)ethyl)piperazin-1-yl)-5-(trifluoromethyl)benzamide;

(S)-2-(4-(3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenylcarbamoyl)-5-(trifluoromethyl)phenyl)piperazin-1-yl)propanoic acid;

tert-butyl 4-(3-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenylcarbamoyl)-5-(trifluoromethyl)phenyl)-3-oxopiperazine-1-carboxylate;

N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-3-(2-oxopiperazin-1-yl)-5-(trifluoromethyl)benzamide;

3-(4-methyl-2-oxopiperazin-1-yl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide;

2-(2-(dimethylamino)ethylamino)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-6-(trifluoromethyl)isonicotinamide;

3-(1-(3,3-difluoropyrrolidin-1-yl)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide, and

3-(1-(3,3-difluoroazetidin-1-yl)ethyl)-N-(4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenyl)-5-(trifluoromethyl)benzamide.