Reagentless optical analyte detection system
First Claim
1. An implantable microspectrometer, comprising:
- an optical sampling cell within a cell housing, said cell housing further defining a fluid inlet port and a fluid outlet port, the fluid inlet port configured to receive an optical sampling fluid from a test subject;
an electromagnetic radiation source in communication with a first portion of the optical sampling cell housing and configured to irradiate at least a portion of the optical sampling fluid with electromagnetic radiation; and
an electromagnetic radiation detector in communication with a second portion of the optical sampling cell housing and configured to detect electromagnetic radiation emanating from the optical sampling cell,wherein the implantable microspectrometer can optically detect at least one parameter of an analyte contained within the optical sampling fluid in the absence of a reagent, and wherein the implantable microspectrometer occupies a total volume in the range of from about 0.01 cm3 to about 1.0 cm3.
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Accused Products
Abstract
Disclosed is an implantable microspectrometer for the reagentless optical detection of an analyte in a sample fluid. The microspectrometer comprises an optical sampling cell having a cell housing defining a fluid inlet port and a fluid outlet port, the fluid inlet port configured to receive an optical sampling fluid from a test subject; an electromagnetic radiation source in communication with a first portion of the optical sampling cell housing and configured to irradiate at least a portion of the optical sampling fluid with electromagnetic radiation; and an electromagnetic radiation detector in communication with a second portion of the optical sampling cell housing and configured to detect electromagnetic radiation emanating from the optical sampling cell. In use, the implantable microspectrometer can optically detect at least one parameter of an analyte contained within the optical sampling fluid in the absence of an added reagent.
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Citations
48 Claims
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1. An implantable microspectrometer, comprising:
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an optical sampling cell within a cell housing, said cell housing further defining a fluid inlet port and a fluid outlet port, the fluid inlet port configured to receive an optical sampling fluid from a test subject; an electromagnetic radiation source in communication with a first portion of the optical sampling cell housing and configured to irradiate at least a portion of the optical sampling fluid with electromagnetic radiation; and an electromagnetic radiation detector in communication with a second portion of the optical sampling cell housing and configured to detect electromagnetic radiation emanating from the optical sampling cell, wherein the implantable microspectrometer can optically detect at least one parameter of an analyte contained within the optical sampling fluid in the absence of a reagent, and wherein the implantable microspectrometer occupies a total volume in the range of from about 0.01 cm3 to about 1.0 cm3. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. An implantable microspectrometer for the reagentless optical detection of an analyte in fluid sample, comprising
an optical sampling cell within a cell housing, said cell housing further defining a fluid inlet port and a fluid outlet port, the fluid inlet port configured to receive an optical sampling fluid from a test subject; -
a means for generating electromagnetic radiation, whereby the means for generating radiation is in communication with a first portion of the optical sampling cell housing and configured to irradiate at least a portion of the optical sampling fluid with electromagnetic radiation; a means for detecting electromagnetic radiation, whereby the means for detecting electromagnetic radiation is in communication with a second portion of the optical sampling cell housing and configured to detect electromagnetic radiation emanating from the optical sampling cell, wherein the implantable microspectrometer can optically detect at least one parameter of an analyte contained within the optical sampling fluid in the absence of a reagent, and wherein the implantable microspectrometer occupies a total volume in the range of from about 0.01 cm3 to about 1.0 cm3.
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36. A method for the reagentless optical detection of an analyte in a fluid sample, comprising the steps of:
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providing a microspectrometer, comprising;
(i) an optical sampling cell within a cell housing, said cell housing further defining a fluid inlet port and a fluid outlet port, the fluid inlet port;
(ii) an electromagnetic radiation source in communication with a first portion of the optical sampling cell housing; and
(iii) an electromagnetic radiation detector in communication with a second portion of the optical sampling cell housing;obtaining a fluid sample containing an analyte from a test subject; conveying the obtained fluid sample through the inlet port in to the optical sampling cell; generating electromagnetic radiation from the electromagnetic radiation source and irradiating at least a portion of the fluid sample within the optical sampling cell; optically detecting electromagnetic radiation emanating from the optical sampling cell with the electromagnetic radiation detector; and returning at least a portion of the obtained fluid sample contained within the optical sampling cell to the test subject, wherein the microspectrometer occupies a total volume in the range of from about 0.01 cm3 to about 1.0 cm3. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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Specification