Device for predicting and managing blood glucose by analyzing the effect of, and controlling, pharmacodynamic insulin equivalents

• US 8,204,729 B2
• Filed: 11/01/2007
• Issued: 06/19/2012
• Est. Priority Date: 11/01/2006
• Status: Expired due to Fees

• Current Assignee: Philip Michael Sher
• Original Assignee: Philip Michael Sher
• Inventors: Sher, Philip Michael
• Primary Examiner(s): JONES, HUGH M
• Application Number:
  US12/063,665
• Publication Number:
  US 20100138197A1
• Time in Patent Office: 1,692 Days
• Field of Search: 703/11
• US Class Current: 703/11
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

Embodiments of the invention are devices for assisting users in the management of blood glucose concentration levels in patients. Devices of the invention provide users with detailed information related to the pharmacodynamic behavior of insulin in a patient. By displaying and accepting information concerning time-dependent rates and amounts of pharmacodynamic insulin unit equivalents, the devices of the invention empower the user to make effective decisions regarding insulin dosing.

Claims

1. A device for managing blood glucose concentration comprising:

a means for inputting at least two recent past blood glucose concentration data items, each data item comprising a blood glucose concentration value and a time-of-measurement value;

a means for inputting insulin delivery data items, each data item comprising an insulin dosage amount and a time-of-delivery value;

a means for inputting insulin time-action profile data;

a means for inputting patient R_BGC/I data, the responsiveness of the patient'"'"'s blood glucose concentration to insulin, optionally as a function of time of day;

a means for inputting BGC-neutral phamacodynamic insulin unit equivalent expenditure data,

the data selected from the group consisting of;

BGC-neutral d(PDIUE)/dt data, a BGC-neutral rate of pharmacodynamic insulin unit equivalent expenditure; and

BGC-neutral

2. The device of claim 1 further comprising at least one of:

a glucose meter connected to the microprocessor;

an insulin pump connected to the microprocessor.

3. A device for managing blood glucose concentration comprising:

a means for inputting BGC-neutral phamacodynamic insulin unit equivalent expenditure data,

the data selected from the group consisting of;

BGC-neutral d(PDRIE)/dt data, a BGC-neutral rate of pharmacodynamic insulin unit equivalent expenditure; and

BGC-neutral

4. The device of claim 3 further comprising at least one of:

a glucose meter connected to the microprocessor;

an insulin pump connected to the microprocessor.

5. A device for managing blood glucose concentration comprising:

a means for inputting insulin delivery data items, each data item comprising

an insulin dosage amount and a time-of-delivery value;

a means for inputting insulin time-action profile data;

a means for inputting BGC-neutral phamacodynamic insulin unit equivalent expenditure data, the data selected from the group consisting of;

BGC-neutral d(PDIUE)/dt data, a BGC-neutral rate of pharmacodynamic insulin unit equivalent expenditure; and

BGC-neutral

6. The device of claim 5 further comprising

an insulin pump connected to the microprocessor.

7. A device for managing blood glucose concentration comprising:

a means for inputting at least two recent past blood glucose concentration data items, each data item comprising a blood glucose concentration value and a time-of-measurement value;

a means for inputting insulin delivery data items, each data item comprising an insulin dosage amount and a time-of-delivery value;

a means for inputting insulin time-action profile data;

a means for inputting patient R_BGC/I data, the responsiveness of the patient'"'"'s blood glucose concentration to insulin, optionally as a function of time of day;

a microprocessor connected to the input means;

the microprocessor connected to a digital memory;

the microprocessor connected to wired or wireless communication means;

the microprocessor configured to perform calculations based upon;

inputted recent past blood glucose concentration data;

inputted insulin delivery data;

inputted insulin time-action profile data;

inputted patient R_BGC/I data;

the microprocessor configured to calculate an item selected from the group consisting of;

BGC-neutral d(PDHJE)/dt, a BGC-neutral rate of pharmacodynamic insulin unit equivalent expenditure; and

BGC-neutral

8. The device of claim 7 further comprising at least one of:

a glucose meter connected to the microprocessor;

an insulin pump connected to the microprocessor.

9. A device for managing blood glucose concentration comprising:

a means for inputting insulin time-action profile data;

a means for inputting BGC-neutral phamacodynamic insulin unit equivalent expenditure data,

the data selected from the group consisting of;

BGC-neutral d(PDIUE)/dt data, a BGC-neutral rate of pharmacodynamic insulin unit equivalent expenditure; and

BGC-neutral

10. The device of claim 9 further configured to output an insulin delivery-over-time function to an insulin pump.

11. The device of claim 9 wherein the microprocessor is connected to wired or wireless communication means.