Device, system, and method for controllably reducing inflammatory mediators in a subject
First Claim
Patent Images
1. A method for treating an inflammatory disease or condition in a subject comprising:
- providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, andflowing blood through the device to treat the inflammatory disease or condition in the subject,wherein the one or more reactive biological or chemical compounds includes one or more binding agents including one or more of lectin, binding protein, catalytic antibody, catalytic aptamer, protease conjugate, or photoactivatable agent conjugate.
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Accused Products
Abstract
Devices, systems, and methods are provided for controlling an inflammatory response in a subject. Extracorporeal devices, systems, and methods are provided that alter the functional structure of one or more inflammatory mediators in the peripheral blood of the subject. The device or system is useful in a method for treating an inflammatory disease or condition in the subject.
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Citations
28 Claims
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1. A method for treating an inflammatory disease or condition in a subject comprising:
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providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, and flowing blood through the device to treat the inflammatory disease or condition in the subject, wherein the one or more reactive biological or chemical compounds includes one or more binding agents including one or more of lectin, binding protein, catalytic antibody, catalytic aptamer, protease conjugate, or photoactivatable agent conjugate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method for treating an inflammatory disease or condition in a subject comprising:
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providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, and flowing blood through the device to treat the inflammatory disease or condition in the subject, including a sensor configured to detect the one or more inflammatory mediators in the peripheral blood and a controller in communication with the sensor and configured to adjust the one or more reactive biological or chemical compounds to achieve a target value of the detected one or more inflammatory mediators in the peripheral blood of the subject, wherein the controller is configured to control interaction between the one or more reactive components and the one or more inflammatory mediators in the treatment chamber by modulating release of the one or more biological or chemical compounds into the treatment chamber.
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17. A method for treating an inflammatory disease or condition in a subject comprising:
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providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, and flowing blood through the device to treat the inflammatory disease or condition in the subject, including a sensor configured to detect the one or more inflammatory mediators in the peripheral blood and a controller in communication with the sensor and configured to adjust the one or more reactive biological or chemical compounds to achieve a target value of the detected one or more inflammatory mediators in the peripheral blood of the subject, wherein the controller is configured to derive the target value based on a desired concentration of the one or more inflammatory mediators in the peripheral blood, a desired range of concentrations of the one or more inflammatory mediators in the peripheral blood, a desired ratio of concentrations of two or more inflammatory mediators in the peripheral blood, or a desired ratio of levels of two or more inflammatory mediators in the peripheral blood.
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18. A method for treating an inflammatory disease or condition in a subject comprising:
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providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, and flowing blood through the device to treat the inflammatory disease or condition in the subject, including a sensor configured to detect the one or more inflammatory mediators in the peripheral blood and a controller in communication with the sensor and configured to adjust the one or more reactive biological or chemical compounds to achieve a target value of the detected one or more inflammatory mediators in the peripheral blood of the subject, wherein the sensor and the controller are configured to control levels of the one or more inflammatory mediators to limit a deviation from the target value. - View Dependent Claims (19)
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20. A method for treating an inflammatory disease or condition in a subject comprising:
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providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, and flowing blood through the device to treat the inflammatory disease or condition in the subject, including a sensor configured to detect the one or more inflammatory mediators in the peripheral blood, wherein the sensor is configured to target the device to a site of inflammation in the subject. - View Dependent Claims (21)
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22. A method for treating an inflammatory disease or condition in a subject comprising:
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providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, and flowing blood through the device to treat the inflammatory disease or condition in the subject, including a sensor configured to detect the one or more inflammatory mediators in the peripheral blood wherein the sensor includes a physical sensor including one or more of a recognition-based substrate, an aptamer-based substrate, an antibody-based substrate, surface plasmon resonance, genetically-modified cells, or genetically-modified cells with receptor-linked signaling. - View Dependent Claims (23)
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24. A method for treating an inflammatory disease or condition in a subject comprising:
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providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, and flowing blood through the device to treat the inflammatory disease or condition in the subject, including a sensor configured to detect the one or more inflammatory mediators in the peripheral blood wherein the sensor is configured to target the device to a site having an elevated level of the inflammatory mediators.
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25. A method for treating an inflammatory disease or condition in a subject comprising:
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providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, and flowing blood through the device to treat the inflammatory disease or condition in the subject, including a sensor configured to detect the one or more inflammatory mediators in the peripheral blood, wherein the sensor is configured to detect cytokines, T-lymphocytes, B-lymphocytes, or antibodies.
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26. A method for treating an inflammatory disease or condition in a subject comprising:
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providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, and flowing blood through the device to treat the inflammatory disease or condition in the subject, including a sensor configured to detect the one or more inflammatory mediators in the peripheral blood, wherein the sensor is configured to detect body temperature, vital signs, edema, oxygen level, or pathogen/toxin level of the subject.
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27. A method for treating an inflammatory disease or condition in a subject comprising:
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providing an extracorporeal device including a treatment chamber configured to receive peripheral blood of the subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter the functional structure of one or more inflammatory mediators in the peripheral blood, and flowing blood through the device to treat the inflammatory disease or condition in the subject, including a sensor configured to detect the one or more inflammatory mediators in the peripheral blood, wherein the sensor is configured to detect anaphylatoxins, chemokines, leukotrienes, prostaglandins, complement, coagulation factors, or proinflammatory cytokines. - View Dependent Claims (28)
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Specification