Expandable medical device for delivery of beneficial agent
First Claim
1. An expandable medical device comprising:
- a substantially cylindrical, expandable medical device having a tissue facing side and a luminal side, and formed of a plurality of struts;
a plurality of cylindrical openings in the plurality of struts, the openings extending entirely through the struts from the tissue facing side of the device to the luminal side, with the cylindrical openings having a substantially constant cross section from a radially outermost surface of the strut to a radially innermost surface of the strut;
a beneficial agent provided in the plurality of cylindrical openings; and
a barrier layer asymmetrically positioned adjacent one of the surfaces of the stent provided in the plurality of cylindrical openings and the barrier layer substantially preventing fluid passage and configured to substantially prevent delivery of the beneficial agent to a first of said sides of the medical device while allowing directional delivery of the beneficial agent to a second of said sides of the medical device so that the majority of the beneficial agent is released from the through openings in a direction opposite the barrier layer when the medical device is placed in a patient.
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Abstract
An expandable medical device has elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
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Citations
21 Claims
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1. An expandable medical device comprising:
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a substantially cylindrical, expandable medical device having a tissue facing side and a luminal side, and formed of a plurality of struts; a plurality of cylindrical openings in the plurality of struts, the openings extending entirely through the struts from the tissue facing side of the device to the luminal side, with the cylindrical openings having a substantially constant cross section from a radially outermost surface of the strut to a radially innermost surface of the strut; a beneficial agent provided in the plurality of cylindrical openings; and a barrier layer asymmetrically positioned adjacent one of the surfaces of the stent provided in the plurality of cylindrical openings and the barrier layer substantially preventing fluid passage and configured to substantially prevent delivery of the beneficial agent to a first of said sides of the medical device while allowing directional delivery of the beneficial agent to a second of said sides of the medical device so that the majority of the beneficial agent is released from the through openings in a direction opposite the barrier layer when the medical device is placed in a patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An expandable medical device comprising:
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an expandable cylindrical device having a plurality of struts; a plurality of cylindrical through openings in the plurality of struts, each opening having a radial innermost end and a radial outermost end; a beneficial agent provided in the plurality of through openings; and a degradable barrier layer asymmetrically positioned at the radial innermost end of the plurality of through openings, the barrier layer degrading more slowly than the beneficial agent and the barrier layer substantially preventing fluid passage and configured to substantially prevent delivery of the beneficial agent through the radial innermost end of the opening so that the majority of the beneficial agent is released from the through openings in a direction opposite the barrier layer when the medical device is placed in a patient. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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Specification