Integrated blood treatment module
First Claim
Patent Images
1. An integrated blood treatment module, comprising:
- a blood treatment device having;
a housing having a longitudinal axis,a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port,a second end-cap closing a second end of the housing;
a pump hose for a peristaltic pump, wherein the pump hose has a first end fluidly connected to the housing and a second end that is fluidly connected to the blood inlet port; and
a degassing device connected to the second end-cap having;
a first chamber having an inlet for receiving a liquid flowing into the second end-cap, anda second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid,wherein the outlet of the second chamber is above the inlet of the first chamber,wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway,wherein the second chamber has a downstream portion that extends below the passageway, andwherein the downstream portion of the second chamber extends completely around an upper region of the first chamber and only partially around a lower region of the first chamber.
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Accused Products
Abstract
An integrated blood treatment module comprises a blood treatment device (1) having a housing (2) and a first end-cap (4) and a second end-cap (5) closing both ends of the housing (2). A pump hose (17) for a peristaltic pump has a first end (18) that is secured to the housing (2) and a second end (16) that is connected to a blood inlet port (15) of the first end-cap (4) so as to form a loop. A degassing device (30) is connected to the second end-cap (5). The degassing device (30), which, in use, is full of liquid, comprises a hydrophobic membrane through which bubbles and micro-bubbles escape the degassing device.
49 Citations
49 Claims
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1. An integrated blood treatment module, comprising:
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a blood treatment device having; a housing having a longitudinal axis, a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end fluidly connected to the housing and a second end that is fluidly connected to the blood inlet port; and a degassing device connected to the second end-cap having; a first chamber having an inlet for receiving a liquid flowing into the second end-cap, and a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, wherein the second chamber has a downstream portion that extends below the passageway, and wherein the downstream portion of the second chamber extends completely around an upper region of the first chamber and only partially around a lower region of the first chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 49)
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39. An integrated blood treatment module, comprising:
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a blood treatment device having; a housing having a longitudinal axis, a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, and a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end that is fluidly connected to the housing and a second end that is fluidly connected to the blood inlet port; a degassing device connected to the second end-cap having; a first chamber having an inlet for receiving a liquid flowing into the second end-cap, and a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, and wherein the second chamber has a downstream portion that extends below the passageway, and wherein the downstream portion of the second chamber extends around an upper region of the downstream portion of the first chamber to a greater degree than around a lower region of the downstream portion of the first chamber; and a support structure having a plurality of conduits defined therein, the blood treatment device being secured to the support structure.
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40. An integrated blood treatment modules comprising:
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a blood treatment device having; a housing having a longitudinal axis, a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, and a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end that is fluidly connected to the housing and a second end that is fluidly connected to the blood inlet; a degassing device connected to the second end-cap having; a first chamber having; an inlet for receiving a liquid flowing into the second end-cap, and a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, wherein the second chamber has a downstream portion that extends below the passageway and asymmetrically surrounds the downstream portion of the first chamber, and wherein the downstream portion of the second chamber extends around an upper region of the downstream portion of the first chamber to a greater degree than around a lower region of the downstream portion of the first chamber; and a support structure having a plurality of conduits defined therein, wherein the blood treatment device is secured to the support structure, and the support structure comprises; a third conduit having an inlet for connection to a blood withdrawal tube, and an outlet connected to the first end of the pump hose; and a fourth conduit having an inlet connected to the second end of the pump hose, and an outlet connected to the blood inlet port of the first end-cap.
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41. An integrated blood treatment module, comprising:
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a blood treatment device having; a housing having a longitudinal axis, a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, and a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end that is fluidly connected to the housing and a second end that is fluidly connected to the blood inlet; a degassing device connected to the second end-cap having; a first chamber having an inlet for receiving a liquid flowing into the second end-cap, and a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, wherein the second chamber has a downstream portion that extends below the passageway, and wherein the degree to which the downstream portion of the second chamber extends around the downstream portion of the first chamber decreases in a downstream direction of flow through the second chamber; and a support structure having a plurality of conduits defined therein, wherein the blood treatment device is secured to the support structure, and the support structure comprises; a third conduit having an inlet for connection to a blood withdrawal tube, and an outlet connected to the first end of the pump hose; and a fourth conduit having an inlet connected to the second end of the pump hose, and an outlet connected to the blood inlet port of the first end-cap, wherein the outlet of the third conduit and the inlet of the fourth conduit are arranged with respect to each other so that the pump hose forms a loop that extends in a plane substantially parallel to the longitudinal axis of the housing.
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42. An integrated blood treatment module, comprising:
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a blood treatment device having; a housing having a longitudinal axis, a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, and a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end that is fluidly connected to the housing and a second end that is fluidly connected to the blood inlet port; a degassing device connected to the second end-cap having; a first chamber having an inlet for receiving a liquid flowing into the second end-cap, and a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, wherein the second chamber has a downstream portion that extends below the passageway, and wherein the degree to which the downstream portion of the second chamber extends around the downstream portion of the first chamber gradually decreases in a downstream direction of flow through the second chamber; and a support structure having a plurality of conduits defined therein, wherein the blood treatment device is secured to the support structure, and the support structure comprises; a third conduit having an inlet for connection to a blood withdrawal tube, and an outlet connected to the first end of the pump hose; and a fourth conduit having an inlet connected to the second end of the pump hose, and an outlet connected to the blood inlet port of the first end-cap, wherein the outlet of the third conduit and the inlet of the fourth conduit are arranged with respect to each.
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43. An integrated blood treatment module, comprising:
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a blood treatment device having; a housing having a longitudinal axis, a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, and a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end that is fluidly connected to the housing and a second end that is fluidly connected to the blood inlet port; and a degassing device connected to the second end-cap having; a first chamber having an inlet for receiving a liquid flowing into the second end-cap, and a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, wherein the second chamber has a downstream portion that extends below the passageway, and wherein the degree to which the downstream portion of the second chamber extends around the downstream portion of the first chamber reduces along a downstream direction of flow through the second chamber, and wherein the downstream portion of the second chamber has a lateral wall that surrounds a longitudinal axis of the degassing device and a bottom wall that is inclined with respect to a longitudinal axis of the degassing device.
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44. An integrated blood treatment module, comprising:
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a blood treatment device having; a housing having a longitudinal axis, a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, and a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end that is fluidly connected to the housing and a second end that is fluidly connected to the blood inlet port; and a degassing device connected to the second end-cap having; a first chamber having an inlet for receiving a liquid flowing into the second end-cap, and a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, wherein the second chamber has a downstream portion that extends below the passageway, wherein the degree to which the downstream portion of the second chamber extends around the downstream portion of the first chamber gradually reduces along a downstream direction of flow through the second chamber, and an upstream portion of the second chamber extending above the passageway that has a decreasing cross-section, with a larger cross-section that is substantially level with the passageway and a smaller cross-section that is substantially level with the hydrophobic membrane.
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45. An integrated blood treatment module, comprising:
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a blood treatment device having; a housing having a longitudinal axis, a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, and a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end that is connected to the housing to provide fluid communication between the first end and the housing, and a second end that is connected to provide fluid communication to the blood inlet port; and a degassing device connected to the second end-cap having; a first chamber having an inlet for receiving a liquid flowing into the second end-cap, a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the degree to which the second chamber extends around the first chamber gradually reduces in a downstream direction of flow through the second chamber, and wherein the first chamber has a downstream portion that partially extends within the second chamber, communicates therewith by a passageway, and has a cross-section selected with respect to a maximal flow rate of the liquid in the module so that a velocity of the liquid in the downstream portion of the first chamber is less than a predetermined velocity.
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46. An integrated blood treatment module, comprising:
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a blood treatment device having; a housing having a longitudinal axis, a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, and a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end that is connected the housing to provide fluid communication between the first end of the pump hose and the housing, and a second end that is connected to provide fluid communication between the second end of the pump hose and the blood inlet port; and a degassing device connected to the second end-cap having; a first chamber having an inlet for receiving a liquid flowing into the second end-cap, and a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, wherein the degree to which the second chamber extends around the downstream portion of the first chamber decreases in a downward direction, and wherein the cross-section of the second chamber of the degassing device at a level of the passageway is selected so that a ratio of a velocity of the liquid within a downstream portion of the first chamber to a velocity of the liquid within the second chamber at the level of the passageway is more than a determined value.
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47. An integrated blood treatment modules comprising:
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a blood treatment device having; a housing having a longitudinal axis, a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, and a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end that is connected to the housing to provide fluid communication between the first end of the pump hose and the housing, and a second end that is connected to provide fluid communication between the second end of the pump hose and the blood inlet port; and a degassing device connected to the second end-cap having; a first chamber having an inlet for receiving a liquid flowing into the second end-cap, and a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, wherein the degree to which the first chamber is encircled by the second chamber reduces in a downstream direction of flow through the second chamber, and wherein the first chamber, the second chamber, and the passageway therebetween are arranged with respect to each other so that a flow pattern of the liquid flowing from the first chamber through the second chamber and to the outlet comprises a component that is tangential to the hydrophobic membrane.
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48. An integrated blood treatment module, comprising:
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a blood treatment device having; a housing having a longitudinal axis; a first end-cap closing a first end of the housing, the first end-cap having a blood inlet port, and a second end-cap closing a second end of the housing; a pump hose for a peristaltic pump, wherein the pump hose has a first end that is connected to the housing to provide fluid communication between the first end of the pump hose and the housing, and a second end that is connected to provide fluid communication between the pump hose and the blood inlet port; and a degassing device connected to the second end-cap having; a first chamber having an inlet for receiving a liquid flowing into the second end-cap, and a second chamber having an opening closed by a hydrophobic membrane and an outlet for discharging the liquid, wherein the outlet of the second chamber is above the inlet of the first chamber, wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, wherein the degree to which the second chamber extends around the downstream portion of the first chamber gradually reduces in a downstream direction of the flow through the second chamber, and wherein the first chamber, the second chambers and the passageway therebetween are arranged with respect to each other so that a flow of the liquid flowing from the first chamber through the second chamber and to the outlet keeps gas bubbles in motion along an inner surface of the hydrophobic membrane.
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Specification