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Solvent/polymer solutions as suspension vehicles

  • US 8,206,745 B2
  • Filed: 06/10/2011
  • Issued: 06/26/2012
  • Est. Priority Date: 02/03/2005
  • Status: Active Grant
First Claim
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1. A stable, nonaqueous suspension formulation, comprising:

  • a particle formulation comprising an active agent, a sugar, methionine, and a buffer, wherein the active agent comprises a peptide, polypeptide, or protein; and

    a nonaqueous, single-phase vehicle consisting essentially of about 10% to about 90% (w/w) polyvinylpyrrolidone and about 90% to about 10% (w/w) benzyl benzoate, wherein the vehicle has a viscosity of between approximately 5,000 poise to approximately 50,000 poise measured at 37°

    C.

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