Osmium compound useful as redox mediator

• US 8,207,336 B2
• Filed: 01/13/2011
• Issued: 06/26/2012
• Est. Priority Date: 06/27/2006
• Status: Active Grant

• Current Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Original Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Inventors: Harding, Ian
• Primary Examiner(s): NAZARIO GONZALEZ, PORFIRIO
• Application Number:
  US13/006,100
• Publication Number:
  US 20110108417A1
• Time in Patent Office: 530 Days
• Field of Search: 546/5, 204/403.05, 204/403.11, 204/403.14
• US Class Current: 546/5
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001

Abstract

Bis-(4,4′dimethyl-2,2′bipyridyl) picolinate osmium complexes are useful as mediators in the electrochemical test strips, such as those used in the detection of glucose.

Claims

1. A compound of the formula

3. The compound of claim 1, wherein Y is Cl⁻

.

5. The improvement of claim 3, wherein the counterion is Cl⁻

.

2. A compound of the formula

4. In a disposable test strip for measurement of glucose in a blood sample, said test strip containing an enzyme that reacts with glucose and a redox mediator compound for regenerating enzyme, the improvement wherein the redox mediator comprises a compound of the formula