Poly(ethylene glycol) containing chemically disparate endgroups

• US 8,207,353 B2
• Filed: 02/17/2010
• Issued: 06/26/2012
• Est. Priority Date: 04/27/2006
• Status: Active Grant

• Current Assignee: Intezyne Technologies
• Original Assignee: Intezyne Technologies
• Inventors: Sill, Kevin N., Skaff, Habib, Breitenkamp, Kurt
• Primary Examiner(s): SHIAO, REI TSANG
• Application Number:
  US12/707,459
• Publication Number:
  US 20100280252A1
• Time in Patent Office: 860 Days
• Field of Search: 548/300.4, 549/359
• US Class Current: 548/300.4
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: C07C 217/08 the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
• CPC Class Codes: C07C 217/84 the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
• CPC Class Codes: C07C 247/04 being saturated
• CPC Class Codes: C07C 271/16 to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
• CPC Class Codes: C07D 207/452 with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
• CPC Class Codes: C07D 207/46 with hetero atoms directly attached to the ring nitrogen atom
• CPC Class Codes: C07D 213/71 to which a second hetero atom is attached
• CPC Class Codes: C07D 263/14 with radicals substituted by oxygen atoms
• CPC Class Codes: C07D 311/88 Nitrogen atoms
• CPC Class Codes: C07D 317/22 etherified
• CPC Class Codes: C07D 491/08 Bridged systems
• CPC Class Codes: C07D 495/04 Ortho-condensed systems
• CPC Class Codes: C07F 9/3808 Acyclic saturated acids which can have further substituents on alkyl
• CPC Class Codes: C07F 9/4006 Esters of acyclic acids which can have further substituents on alkyl
• CPC Class Codes: C07F 9/42 Halides thereof
• CPC Class Codes: C07F 9/65502 the oxygen atom being part of a three-membered ring
• CPC Class Codes: C07F 9/65505 Phosphonic acids containing oxirane groups; esters thereof
• CPC Class Codes: C07F 9/6552 the oxygen atom being part of a six-membered ring
• CPC Class Codes: C08G 2650/48 containing fluorine, e.g. perfluropolyethers
• CPC Class Codes: C08G 65/2612 : containing aromatic or arylaliphatic hydroxyl groups
• CPC Class Codes: C08G 65/2627 : containing aromatic or arylaliphatic amine groups
• CPC Class Codes: C08G 65/263 : containing heterocyclic amine groups
• CPC Class Codes: C08G 65/325 : containing nitrogen
• CPC Class Codes: C08G 65/329 : with organic compounds
• CPC Class Codes: C08G 65/3322 : acyclic
• CPC Class Codes: C08G 65/33303 : containing amino group
• CPC Class Codes: C08G 65/33337 : cyclic
• CPC Class Codes: C08G 65/33396 : having oxygen in addition to nitrogen
• CPC Class Codes: C08G 65/3353 : containing oxygen in addition to phosphorus
• CPC Class Codes: C08G 65/336 : containing silicon
• CPC Class Codes: C08G 65/337 : containing other elements organic compounds containing halogens only as halides of a carboxyl group C08G65/332
• CPC Class Codes: C08G 65/4006 : (I) or (II) containing elements other than carbon, oxygen, hydrogen or halogen as leaving group (X)
• CPC Class Codes: C08L 2203/02 : for biomedical use

Abstract

The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.

Claims

1. A compound selected from any of the following, wherein each n is independently 10-2500: