Probabilistic neurological disorder treatment
First Claim
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1. A method for treating a patient with a neurological disorder, comprising:
- using one or more processors to determine a probability of a seizure occurring in the patient at a selected time point as a function of historical data comprisinga set of reference time points,a relative time elapsed from one of the reference time points to the selected time point, andseizure activity observed at one or more moments when the relative time had elapsed from one or more of the reference time points, andtreating the patient based on the determined probability, wherein treating the patient comprises at least one of evaluating the patient, diagnosing the neurological disorder of the patient, comparing therapies for the patient, alerting the patient, alerting a caregiver, dosing the patient with an implantable medical device, and stimulating the patient with the implantable medical device.
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Abstract
Disclosed are probabilistic approaches to patient evaluation, warning and treatment of a neurological disorder. Disclosed techniques estimate probability distribution functions or cumulative distribution functions, determined by relying on representative historical profiles, comprising information in short and/or long timescales obtained at times that may be intermittent or temporally discontinuous from each other or from other events of interest. The patient may thereby be treated based on the determined probability information.
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Citations
20 Claims
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1. A method for treating a patient with a neurological disorder, comprising:
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using one or more processors to determine a probability of a seizure occurring in the patient at a selected time point as a function of historical data comprising a set of reference time points, a relative time elapsed from one of the reference time points to the selected time point, and seizure activity observed at one or more moments when the relative time had elapsed from one or more of the reference time points, and treating the patient based on the determined probability, wherein treating the patient comprises at least one of evaluating the patient, diagnosing the neurological disorder of the patient, comparing therapies for the patient, alerting the patient, alerting a caregiver, dosing the patient with an implantable medical device, and stimulating the patient with the implantable medical device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for treating a patient with a neurological disorder, comprising:
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using one or more processors to determine a probability of a seizure occurring in the patient after a delivered therapy, the determined probability being a function of historical data comprising a set of reference time points correlated to respective past delivered therapies, a relative time elapsed from one of the reference time points, and a number of seizures occurring at one or more moments when the relative time had elapsed from one or more of the reference time points; determining a therapeutic carry-over effect based on the determined probability, the therapeutic carry-over effect persisting beyond cessation of the delivered therapy; and treating the patient based on the determined probability, comprising delivering a subsequent therapy based on the determined therapeutic carry-over effect.
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11. An apparatus for treating a patient with a neurological disorder, comprising:
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a signal monitoring element for sensing patient activity and outputting a corresponding signal; a treatment delivery element for delivering treatment to the patient; and one or more processors configured to determine a probability of a seizure occurring in the patient at a selected time point as a function of historical data comprising a set of reference time points, a relative time elapsed from one of the reference time points to the selected time point, and seizure activity observed at one or more moments when the relative time had elapsed from one or more of the reference time points, and control treating the patient based on the determined probability, wherein treating the patient comprises at least one of evaluating the patient, diagnosing the neurological disorder of the patient, comparing therapies for the patient, alerting the patient, alerting a caregiver, dosing the patient, and stimulating the patient. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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20. An apparatus for treating a patient with a neurological disorder, comprising:
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a signal monitoring element for sensing patient activity and outputting a corresponding signal; a treatment delivery element for delivering treatment to the patient; and one or more processors configured to determine a probability of a seizure occurring in the patient after a delivered therapy, the determined probability being a function of historical data comprising a set of reference time points, a relative time elapsed from one of the reference time points to the selected time point, and seizure activity observed at one or more moments when the relative time had elapsed from one or more of the reference time points, determine a therapeutic carry-over effect based on the determined probability, the therapeutic carry-over effect persisting beyond cessation of the delivered therapy, and control treating the patient based on the determined probability, the treating the patient comprising delivering a subsequent therapy based on the determined therapeutic carry-over effect.
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Specification