Device and method for the determination of an analyte in a sample of liquid

• US 8,210,031 B2
• Filed: 09/16/2009
• Issued: 07/03/2012
• Est. Priority Date: 09/17/2008
• Status: Expired due to Fees

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Jabs, Holger, Ladiges, Norbert, Fink, Herbert
• Primary Examiner(s): FITZGERALD, JOHN P
• Application Number:
  US12/560,518
• Publication Number:
  US 20100107743A1
• Time in Patent Office: 1,021 Days
• Field of Search: 73/615.9
• US Class Current: 73/61.59
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001

Abstract

A device for determining an analyte in a sample of liquid comprises an analysis apparatus configured to analyze a sample of liquid applied to an analytical area of a test element. The device comprises further an apparatus configured to prepare a surface of the analytical area by conferring hydrophilic properties to the surface. Analytes in test samples are determined by methods employing the device.

Claims

1. A device for the determination of an analyte in a sample of liquid, the device comprising:

an analytical apparatus configured to analyze a sample of liquid after the sample is applied to an analytical area of a test element prepared for an analysis of the sample of liquid; and

incorporating

a hydrophilization apparatus configured to confer hydrophilic properties to a surface in the analytical area during the preparation of the test element.

2. The device of claim 1, wherein the hydrophilization apparatus comprises a plasma-treatment apparatus configured to treat the surface in the analytical area with a plasma during hydrophilization.

3. The device of claim 1, wherein the plasma-treatment apparatus comprises a microwave plasma generator.

4. The device of claim 1, wherein the plasma-treatment apparatus comprises a microplasma reactor.

5. The device of claim 1, wherein the hydrophilization apparatus comprises a surface-treatment apparatus configured to hydrophilize the surface in the analytical area, the surface-treatment apparatus being selected from group consisting of an ultrasound treatment apparatus, a corona treatment apparatus, an air-ionizing apparatus, an ozone generator, and a microwave-treatment apparatus.

6. The device of claim 1, wherein the hydrophilization apparatus is a microapparatus.

7. A method for the determination of an analyte in a sample of liquid with the aid of an analytical instrument, the method comprising:

providing a sample of liquid and a test element, the test element comprising an analytical area;

treating a surface of the analytical area with a hydrophilization apparatus to form a treated analytical area;

applying the sample of liquid to the treated analytical area;

introducing the test element into the analytical instrument; and

analyzing the sample of liquid with an analytical apparatus incorporated into the analytical instrument.

8. The method of claim 7, wherein the hydrophilization apparatus comprises a plasma-treatment apparatus.

9. The method of claim 7, wherein the treating the surface of the analytical area occurs after the introducing the test element.

10. The method of claim 7, wherein the hydrophilization apparatus comprises a microwave plasma generator.

11. The method of claim 7, wherein the hydrophilization apparatus comprises a microplasma reactor.

12. The method of claim 7, wherein the hydrophilization apparatus comprises a surface-treatment unit incorporated into the hydrophilization apparatus, the surface-treatment unit being selected from the group consisting of an ultrasound-treatment apparatus, a corona-treatment apparatus, and air-ionizing apparatus, an ozone generator, and a microwave-treatment apparatus.

13. The method claim 7, wherein the sample comprises blood.