System and method of determining arterial blood pressure and ventricular fill parameters from ventricular blood pressure waveform data
First Claim
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1. An implantable medical device, comprising:
- an input circuit that receives a pressure waveform signal representative of a pressure (P) sensed within a ventricle of a patient'"'"'s heart as a function of time (t); and
a processor that derives from the pressure waveform signal at least one hemodynamic parameter based upon at least one ventricular pressure value during a portion of the pressure waveform signal between a peak ventricular pressure and a beginning of a next ventricular pumping cycle; and
wherein the processor derives an estimated arterial diastolic pressure based upon pressure in the ventricle at a time corresponding to a maximum rate of pressure decline (dP/dtmin).
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Abstract
A system and method of determining hemodynamic parameters uses sensed ventricular blood pressure during a portion of ventricular pressure waveform following peak pressure. An estimated arterial diastolic pressure is based upon an amplitude of the sensed ventricular pressure corresponding to a time at which a first derivative of ventricular pressure as a function of time is at a minimum (dP/dtmin). Fill parameters such as isovolumetric relaxation constant, ventricular suction pressure, atrial kick pressure, and transvalve pressure gradient are derived from measured pressures representing minimum ventricular pressure, ventricular diastolic pressure, and diastasis pressure.
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Citations
15 Claims
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1. An implantable medical device, comprising:
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an input circuit that receives a pressure waveform signal representative of a pressure (P) sensed within a ventricle of a patient'"'"'s heart as a function of time (t); and a processor that derives from the pressure waveform signal at least one hemodynamic parameter based upon at least one ventricular pressure value during a portion of the pressure waveform signal between a peak ventricular pressure and a beginning of a next ventricular pumping cycle; and wherein the processor derives an estimated arterial diastolic pressure based upon pressure in the ventricle at a time corresponding to a maximum rate of pressure decline (dP/dtmin). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An implantable medical device, comprising:
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an input circuit that receives a pressure waveform signal representative of a pressure (P) sensed within a ventricle of a patient'"'"'s heart as a function of time (t); and a processor that derives from the pressure waveform signal at least one hemodynamic parameter based upon at least one ventricular pressure value during a portion of the pressure waveform signal between a peak ventricular pressure and a beginning of a next ventricular pumping cycle; wherein the processor determines from the fill portion of the pressure waveform signal a ventricular diastolic pressure, a minimum ventricular pressure, and a diastasis pressure; wherein the processor derives from the pressure waveform signal at least one ventricular fill parameter based upon pressure values during a fill portion between occurrence of dP/dtmin and the beginning of a next ventricular pumping cycle; and wherein the processor derives an atrial kick parameter based upon a difference between the ventricular end diastolic pressure and the diastasis pressure.
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10. An implantable medical device, comprising:
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an input circuit that receives a pressure waveform signal representative of a pressure (P) sensed within a ventricle of a patient'"'"'s heart as a function of time (t); and a processor that derives from the pressure waveform signal at least one hemodynamic parameter based upon at least one ventricular pressure value during a portion of the pressure waveform signal between a peak ventricular pressure and a beginning of a next ventricular pumping cycle; wherein the processor determines from the fill portion of the pressure waveform signal a ventricular diastolic pressure, a minimum ventricular pressure, and a diastasis pressure; wherein the processor derives from the pressure waveform signal at least one ventricular fill parameter based upon pressure values during a fill portion between occurrence of dP/dtmin and the beginning of a next ventricular pumping cycle; and wherein the processor derives a ventricular suction parameter based upon a difference between the diastasis ventricular pressure and the minimum ventricular pressure.
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11. An implantable medical device, comprising:
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an input circuit that receives a pressure waveform signal representative of a pressure (P) sensed within a ventricle of a patient'"'"'s heart as a function of time (t); and a processor that derives from the pressure waveform signal at least one hemodynamic parameter based upon at least one ventricular pressure value during a portion of the pressure waveform signal between a peak ventricular pressure and a beginning of a next ventricular pumping cycle; wherein the processor determines from the fill portion of the pressure waveform signal a ventricular diastolic pressure, a minimum ventricular pressure, and a diastasis pressure; wherein the processor derives from the pressure waveform signal at least one ventricular fill parameter based upon pressure values during a fill portion between occurrence of dP/dtmin and the beginning of a next ventricular pumping cycle; and wherein the processor derives a transvalve pressure gradient parameter based upon a difference between the ventricular diastolic pressure and the minimum ventricular pressure.
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12. An implantable medical device, comprising:
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an input circuit that receives a pressure waveform signal representative of a pressure (P) sensed within a ventricle of a patient'"'"'s heart as a function of time (t); and a processor that derives from the pressure waveform signal at least one hemodynamic parameter based upon at least one ventricular pressure value during a portion of the pressure waveform signal between a peak ventricular pressure and a beginning of a next ventricular pumping cycle; and wherein the process derives an isovolumetric relaxation constant based upon dP/dtmin, a ventricular pressure at dP/dt (PSTI) and a ventricular pressure at occurrence of an R-wave (VDP).
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13. An implantable medical device, comprising:
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an input circuit that receives a pressure waveform signal representative of a pressure (P) sensed within a ventricle of a patient'"'"'s heart as a function of time (t); and a processor that derives from the pressure waveform signal at least one hemodynamic parameter based upon at least one ventricular pressure value during a portion of the pressure waveform signal between a peak ventricular pressure and a beginning of a next ventricular pumping cycle, wherein the processor derives an atrial kick parameter based upon a difference between ventricular end diastolic pressure and diastasis pressure.
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14. An implantable medical device, comprising:
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an input circuit that receives a pressure waveform signal representative of a pressure (P) sensed within a ventricle of a patient'"'"'s heart as a function of time (t); and a processor that derives from the pressure waveform signal at least one hemodynamic parameter based upon at least one ventricular pressure value during a portion of the pressure waveform signal between a peak ventricular pressure and a beginning of a next ventricular pumping cycle, wherein the processor derives a ventricular suction parameter based upon a difference between diastasis ventricular pressure and minimum ventricular pressure.
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15. An implantable medical device, comprising:
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an input circuit that receives a pressure waveform signal representative of a pressure (P) sensed within a ventricle of a patient'"'"'s heart as a function of time (t); and a processor that derives from the pressure waveform signal at least one hemodynamic parameter based upon at least one ventricular pressure value during a portion of the pressure waveform signal between a peak ventricular pressure and a beginning of a next ventricular pumping cycle, wherein the processor derives a transvalve pressure gradient parameter based upon a difference between ventricular diastolic pressure and minimum ventricular pressure.
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Specification