Electroactive polymer actuated cerebrospinal fluid shunt

• US 8,211,051 B2
• Filed: 09/24/2007
• Issued: 07/03/2012
• Est. Priority Date: 09/24/2006
• Status: Expired due to Fees

• Current Assignee: Aniteal Laboratories, LLC
• Original Assignee: Aniteal Laboratories, LLC
• Inventors: Delaporte, Stephen E.
• Primary Examiner(s): Zalukaeva, Tatyana
• Assistant Examiner(s): Wiest, Philip R
• Application Number:
  US11/903,665
• Publication Number:
  US 20080125690A1
• Time in Patent Office: 1,744 Days
• Field of Search: 604 8- 10, 604/93.01, 604/94.01, 604/95.01, 604/96.01, 604/104, 604245-247, 604/264, 604500-508, 623/3.1, 128/903, 137/1, 137/383, 137/385
• US Class Current: 604/9
• CPC Class Codes: A61B 5/031 Intracranial pressure
• CPC Class Codes: A61M 2205/0283 Electro-active polymers [EAP]
• CPC Class Codes: A61M 27/006 Cerebrospinal drainage; Accessories therefor, e.g. valves

Abstract

A cerebrospinal fluid (CSF) shunt comprises a ventricular catheter and an electroactive polymer actuated valve for regulating the drainage rate of CSF from the brain ventricle of a patient. The shunt system also comprises a distal catheter for discharge of the CSF to a separate location in the patient'"'"'s body such as the peritoneal cavity or atrium of the heart. The electroactive polymer actuated valve regulates the flow rate of CSF through a predetermined threshold pressure, which can be adjusted and programmed externally from the patient'"'"'s body by means of an external control unit signal, as well as through a signal indicated by an internal sensor or an electroactive polymer transducer. The sensor also communicates a signal to the external control unit for indicating the internal pressure at a single location or multiple locations throughout the fully implanted shunt assembly.

Claims

1. A cerebrospinal fluid shunt system comprising:

a valve having a longitudinal axis, the valve comprising an electroactive polymer, a ring element, a ball, and a spring, the spring positioned between the ring element and the ball, wherein, when actuated, the electroactive polymer is configured to apply a force to the ring element in a longitudinal direction parallel to the longitudinal axis causing the ring element to slide in the longitudinal direction and thereby provide a force on the ball through the spring;

the electroactive polymer being configured as a pressure sensor to detect a pressure differential between an inlet of the valve and an outlet of the valve;

an internal control unit configured to transmit the detected pressure differential; and

an external control unit configured to receive the transmitted pressure differential;

wherein, in response to receiving the pressure differential, the external control unit provides a signal to the electroactive polymer causing the electroactive polymer to modify a force on the ring element to adjust the valve pressure, thereby allowing the valve pressure to be adjusted after the valve has been implanted in a patient.

2. The cerebrospinal fluid shunt system as in claim 1, wherein the electroactive polymer senses pressure created by cerebrospinal fluid, wherein the sensed pressure is used to adjust the valve pressure.

3. The cerebrospinal fluid shunt system as in claim 1, wherein the electroactive polymer is further configured to apply the force to the ring element in a direction with or against the flow of the cerebrospinal fluid through the valve.

4. A shunt system implantable in a body comprising:

a ventricular catheter having a first end and a second end, the first end of the ventricular catheter configured to be inserted into the brain ventricle within the body;

a distal catheter having a first end and a second end, the first end of the distal catheter configured to be inserted into a secondary cavity within the body; and

an electroactive polymer actuated valve having a longitudinal axis and comprising an inlet aperture and an outlet aperture, the second end of the ventricular catheter coupled to the inlet aperture and the second end of the distal catheter coupled to the outlet aperture, the electroactive polymer actuated valve configured to regulate a flow rate of cerebrospinal fluid (CSF) being redirected from the brain ventricle to the secondary cavity, the electroactive polymer actuated valve having an adjustable threshold pressure to regulate the flow rate of the CSF;

wherein the flow rate of the CSF is adjusted by actuating at least one electroactive polymer of the electroactive polymer actuated valve to cause the at least one electroactive polymer to apply a force, directed in a longitudinal direction parallel to the longitudinal axis, to a moveable ring element within the electroactive polymer actuated valve causing the moveable ring element to slide in the longitudinal direction and thereby modify a force on a ball within the electroactive polymer actuated valve, thereby allowing the CSF to be adjusted after the shunt system has been implanted in the body, the electroactive polymer actuated valve having a spring member disposed between the moveable ring element and the ball.

5. The implantable shunt system as in claim 4, further comprising an external control unit for adjusting the threshold pressure externally from the body.

6. The implantable shunt system as in claim 4, wherein the at least one electroactive polymer is configured as a transducer for sensing pressure created by the CSF, wherein the sensed pressure is used to adjust the threshold pressure.

7. The implantable shunt system as in claim 6, wherein a differential pressure between the ventricular catheter and the distal catheter results in a deflection of the at least one electroactive polymer which converts mechanical energy of the deflection into a voltage signal for actuating the electroactive polymer actuated valve.

8. The implantable shunt system as in claim 7, wherein the voltage signal created by the deflection is transmitted to an external control unit outside of the body.

9. The implantable shunt system as in claim 4, wherein:

the spring member is disposed between the ring element and the ball at the inlet aperture, wherein the ring element, ball, and spring member are configured to control the flow rate through the electroactive polymer actuated valve;

wherein the at least one electroactive polymer is disposed in a primary valve chamber of the electroactive polymer actuated valve and is configured for actuating the ring element, ball, and spring member.

10. The implantable shunt system as in claim 9, wherein the inlet aperture includes at least one opening to provide a filtering effect.

11. The implantable shunt system as in claim 4, wherein actuating the at least one electroactive polymer causes the at least one electroactive polymer to apply the force to the moveable ring element in a direction with or against the flow of the CSF through the electroactive polymer actuated valve.

12. A shunt system implantable in a body comprising:

an electroactive polymer actuated means for regulating a flow rate of cerebrospinal fluid (CSF) being redirected from the brain ventricle to a secondary cavity within the body, the electroactive polymer actuated means having an adjustable threshold pressure to regulate the flow rate of the CSF, the electroactive polymer actuated means configured to regulate the flow rate by applying a force to a moveable ring element in a longitudinal direction parallel to a longitudinal axis of the electroactive polymer actuated means, the force causing the moveable ring element to slide in the longitudinal direction and thereby modify a corresponding force on a ball through a spring positioned between the ring element and the ball, wherein the moveable ring element, ball, and spring reside within a flow path of the CSF;

means for sensing pressure created by the CSF and generating a signal indicative of the pressure; and

control means for receiving the pressure signal and controlling the electroactive polymer actuated means, based on the sensed pressure, to regulate the flow rate of the CSF after the shunt system is implanted in the body.

13. The implantable shunt system as in claim 12, further comprising an external control means for adjusting the threshold pressure externally from the body.

14. The implantable shunt system as in claim 12, wherein the means for sensing creates a signal readable externally from the body.

15. The implantable shunt system as in claim 12, further comprising a means for filtering the CSF flowing through the electroactive polymer actuated means.

16. The implantable shunt system as in claim 12, further comprises a catheter having one end disposed in the brain ventricle and a second end disposed in the secondary cavity within the body and at least two electroactive polymer actuated means.

17. The implantable shunt system as in claim 12, wherein the electroactive polymer actuated means is configured to apply the force to the moveable ring element substantially parallel with the flow path of the CSF at the electroactive polymer actuated means.