Drug solution preparing kit

• US 8,211,082 B2
• Filed: 06/19/2007
• Issued: 07/03/2012
• Est. Priority Date: 06/19/2006
• Status: Expired due to Fees

• Current Assignee: Nipro Corporation
• Original Assignee: Nipro Corporation
• Inventors: Hasegawa, Mitsuru, Ishikawa, Atsushi, Ohguro, Takeshi, Oyagi, Suguru
• Primary Examiner(s): DEAK, LESLIE R
• Application Number:
  US12/305,640
• Publication Number:
  US 20090326506A1
• Time in Patent Office: 1,841 Days
• Field of Search: 604411-416
• US Class Current: 604/416
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/1475 Inlet or outlet ports
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2017 having three or more piercing ends
• CPC Class Codes: A61J 1/2058 having multiple connecting ports
• CPC Class Codes: A61J 1/2062 with directional valves
• CPC Class Codes: A61J 1/2072 for internal venting
• CPC Class Codes: A61J 1/2075 for external venting
• CPC Class Codes: A61J 1/2086 for fluid filtration
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61M 2005/1623 Details of air intake
• CPC Class Codes: A61M 2205/7536 allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
• CPC Class Codes: A61M 5/162 Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube in jet-action syringes A61M5/30; connectors for tubes having sealed ends and a needle for piercing them A61M39/14

Abstract

To provide a drug solution preparing kit which can be handled with ease in a substantially aseptic manner, and has no risk that a leakage of a drug solution such as a splash and a dispersion of an aerosol to an ambient environment occurs upon preparation of the drug solution There is provided a drug solution preparing kit including a pre-filled syringe and a transfusing tool, wherein the pre-filled syringe includes a sealing member which seals the tip end and can not be removed from the tip end, and that the transfusing tool includes a one-way valve which can discharge only gas from the system in an irreversible manner, and a filter which is provided so as to adjoin to the second communication channel with respect to the one-way valve.

Claims

1. A drug solution preparing kit comprising a pre-filled syringe and a transfusing tool,

wherein said pre-filled syringe includes:

a cylinder-shaped barrel including a tip end and a base end, the tip end and the base end being open,

a sealing member configured to seal said tip end and unable to be removed from said tip end, and

a plunger inserted into said barrel in a liquid-tight manner and a slidable manner,

said barrel, said plunger and said sealing member defining a space filled with a drug solution,

said transfusing tool including;

a barrel attaching part, the tip end of said barrel being attached to the barrel attaching part,

a first needle provided on said barrel attaching part and configured to penetrate through said sealing member,

a vial attaching part, an inlet of a vial being configured to be attached to the vial attaching part,

a second needle provided on said vial attaching part and configured to penetrate through a plug for the inlet of the vial,

a first communication channel establishing communicative connection between said first needle and said second needle, and

a second communication channel establishing communicative connection between said second needle and a port and being formed independently of said first communication channel,

wherein said port includes a one-way valve which can discharge only gas from the system in an irreversible manner, and a filter which is provided so as to adjoin to said second communication channel with respect to said one-way valve, and

wherein the filter is arranged between an opening of the second communication channel and the one-way valve.

2. The drug solution preparing kit according to claim 1, wherein said port includes a chamber which is connected to a side opposite to the second communication channel in a fluid-tight manner so as to adjoin to the one-way valve and receive the gas discharged from the system.

3. The drug solution preparing kit according to claim 1, wherein said first needle is covered so as to be communicatively connected only when the tip end of said barrel is attached to said barrel attaching part.

4. The drug solution preparing kit according to claim 1, wherein said first communication channel has an opening which is provided so as to prevent a liquid introduced from the barrel from being directly jetted to a bottom side of the vial.

5. The drug solution preparing kit according to claim 1, wherein said filter has a hydrophobic property.

6. The drug solution preparing kit according to claim 1, wherein the inlet of the vial is configured to be unable to be removed from said vial attaching part once being attached to said vial attaching part.

7. The drug solution preparing kit according to claim 1, wherein said first needle and said second needle are integrated into one.

8. The drug solution preparing kit according to claim 1, wherein said sealing member has a tip end on which an annular hood is formed.

9. A drug solution preparing kit comprising a pre-filled syringe and a transfusing tool,

wherein said pre-filled syringe includes:

a cylinder-shaped barrel including a tip end and a base end, the tip end and the base end being open,

a sealing member configured to seal said tip end and unable to be removed from said tip end, and

a plunger inserted into said barrel in a liquid-tight manner and a slidable manner,

said barrel, said plunger and said sealing member defining a space filled with a drug solution,

said transfusing tool including;

a barrel attaching part, the tip end of said barrel being attached to the barrel attaching part,

a first needle provided on said barrel attaching part and configured to penetrate through said sealing member,

a vial attaching part, an inlet of a vial being configured to be attached to the vial attaching part,

second and third needles provided on said vial attaching part and configured to penetrate through a plug for the inlet of the vial,

a first communication channel establishing communicative connection between said first needle and said second needle, and

a second communication channel establishing communicative connection between said third needle and a port,

wherein said port includes a one-way valve which can discharge only gas from the system in an irreversible manner, and a filter which is provided so as to adjoin to said second communication channel with respect to said one-way valve, and

wherein the filter is arranged between an opening of the second communication channel and the one-way valve.