Conversion of nitrogen dioxide (NO 2 ) to nitric oxide (NO)

• US 8,211,368 B2
• Filed: 05/23/2011
• Issued: 07/03/2012
• Est. Priority Date: 03/23/2007
• Status: Active Grant

• Current Assignee: Vero Biotech LLC
• Original Assignee: GENO LLC
• Inventors: Fine, David H., Rounbehler, David P., Vasquez, Gregory B.
• Primary Examiner(s): BHAT, NINA NMN
• Application Number:
  US13/113,787
• Publication Number:
  US 20110240020A1
• Time in Patent Office: 407 Days
• Field of Search: 422/120, 422/122, 951/02, 951/20, 951/28, 128/203.12, 128/203.14, 128/204.24, 128/204.21, 961/53, 961/54
• US Class Current: 422/120
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 2016/1025 the O2 concentration
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C01B 21/24 Nitric oxide (NO) C01B21/203 takes precedence

Abstract

A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

Claims

1. A method of providing a therapeutic gas including nitric oxide to a mammal comprising:

connecting a permeation tube to a source of nitrogen dioxide via a diffusion cell;

connecting a receptacle to the permeation tube, the receptacle including an inlet, an outlet, and a surface-active material including an antioxidant, wherein the inlet is configured to receive the flow of nitrogen dioxide from the permeation tube;

diffusing gaseous nitrogen dioxide from the source of nitrogen dioxide into an air flow;

communicating the air flow to the outlet through the surface-active material; and

converting the gaseous nitrogen dioxide to nitric oxide at ambient temperature.

2. The method of claim 1, wherein the source of nitrogen dioxide is liquid nitrogen dioxide.

3. The method of claim 1, wherein the permeation tube length is scaled to provide a predetermined dose of nitrogen dioxide at a particular temperature.

4. The method of claim 1, wherein the permeation tube further comprises a movable, non-permeable sheath over the length of the tube.

5. The method of claim 4, further connecting the permeation tube to the diffusion cell through a diffusion needle.

6. The method of claim 5, wherein the diffusion needle further comprises holes on the side of needle and an outer sheath surrounding the holes, wherein the sheath has slots fitted around the needle configured to be turned to uncover the uncover the desired hole.

7. The method of claim 1, further connecting the diffusion cell to a plurality of permeation tubes through a plurality of narrow bore diffusion needles.

8. The method of claim 1, wherein the surface-active material is coated with the antioxidant.

9. The method of claim 1, wherein the surface-active material comprises a silica gel.

10. The method of claim 1, wherein the antioxidant comprises ascorbic acid.

11. The method of claim 1, wherein the antioxidant comprises alpha tocopherol or gamma tocopherol.

12. The method of claim 1, wherein the receptacle is a first receptacle, the method further comprising connecting a second receptacle to the first receptacle, wherein the second receptacle is configured to receive the flow from the first receptacle and includes a second inlet, a second outlet, and a second surface-active material including an aqueous solution of an antioxidant and wherein the second inlet is configured and fluidly communicates the flow to the second outlet through the second surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature.

13. A method of providing a therapeutic gas including nitric oxide to a mammal comprising:

connecting a pressure regulator to a source of nitrogen dioxide;

attaching a receptacle to the pressure regulator, the receptacle including an inlet, an outlet, and a surface-active material coated with an antioxidant, wherein the inlet is configured to receive the flow of nitrogen dioxide from the permeation tube;

communicating the flow to the outlet through the surface-active material;

converting the gaseous nitrogen dioxide to nitric oxide at ambient temperature; and

transporting the therapeutic gas to a mammal.

14. The method of claim 13, further placing the receptacle on the low pressure side of the pressure regulator.

15. The method of claim 13, the method further comprising connecting a second receptacle to the first receptacle, wherein the second receptacle is configured to receive the flow from the first receptacle and includes a second inlet, a second outlet, and a second surface-active material including an aqueous solution of an antioxidant and wherein the second inlet is configured and fluidly communicates the flow to the second outlet through the second surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature.

16. The method of claim 13, wherein the pressure regulator includes an inlet port and an outlet port that connects the receptacle with a gas bottle having nitrogen dioxide in air.

17. The method of claim 13, wherein the surface-active material is coated with the aqueous solution of the antioxidant.

18. The method of claim 13, wherein the surface-active material comprises a silica gel.

19. The method of claim 13, wherein the antioxidant comprises ascorbic acid.

20. The method of claim 13, wherein the antioxidant comprises alpha tocopherol or gamma tocopherol.