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Chimeric receptor genes and cells transformed therewith

  • US 8,211,422 B2
  • Filed: 10/24/1995
  • Issued: 07/03/2012
  • Est. Priority Date: 03/18/1992
  • Status: Expired due to Fees
First Claim
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1. An adoptive immunotherapeutic method of treating a patient having a cancer bearing tumor-specific antigen with cells having immunological specificity to a selected tumor-specific antigen, comprising administering to said patient cells that have been transformed with a chimeric gene, wherein said cells are peripheral blood lymphocytes, said chimeric gene containing a) a first DNA segment encoding a single-chain Fv (scFv) domain of an antibody directed against the selected tumor-specific antigen and b) a second DNA segment encoding a lymphocyte-activating molecule subunit of a Fc receptor to express the scFv domain and the lymphocyte-activating molecule on the surface of the lymphocytes and to provide said antibody-type specificity.

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