Hot-melt TTS for administering rotigotine
First Claim
1. A transdermal therapeutic system (TTS) comprising an active-substance-containing cement matrix, wherein the cement matrix comprises a hot-meltable adhesive in which the active substance is dispersed and melted using a hot-melt process, and wherein the active substance is rotigotine and is partly or completely dissolved in the adhesive;
- and wherein the hot-melt process comprises melting and homogenizing components of the cement matrix and rotigotine without solvent in an extruder at a temperature between 120°
C. and 160°
C. prior to lamination of the cement matrix.
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Accused Products
Abstract
This patent application relates to a transdermal therapeutic system (TTS) that comprises a Rotigotine-containing cement layer, characterized in that the cement layer contains a hot-meltable adhesive in which Rotigotine as the active substance is dispersed and partly or completely dissolved.
The patent application further relates to the use of Rotigotine in the production of the cement layer of a TTS by a hot-melt method.
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Citations
25 Claims
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1. A transdermal therapeutic system (TTS) comprising an active-substance-containing cement matrix, wherein the cement matrix comprises a hot-meltable adhesive in which the active substance is dispersed and melted using a hot-melt process, and wherein the active substance is rotigotine and is partly or completely dissolved in the adhesive;
- and wherein the hot-melt process comprises melting and homogenizing components of the cement matrix and rotigotine without solvent in an extruder at a temperature between 120°
C. and 160°
C. prior to lamination of the cement matrix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 21, 22, 23, 24, 25)
- and wherein the hot-melt process comprises melting and homogenizing components of the cement matrix and rotigotine without solvent in an extruder at a temperature between 120°
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16. A method for preparing a TTS that comprises a rotigotine-containing cement matrix, the method comprising:
melting and homogenizing components of the cement matrix and rotigotine without solvent in an extruder at a temperature between 120°
C. and 160°
C. prior to lamination of the cement matrix.- View Dependent Claims (17, 18, 19)
Specification