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Osmotic drug delivery devices containing suspension formulations comprising particles having active agents and nonaqueous single-phase vehicles

  • US 8,211,467 B2
  • Filed: 11/01/2010
  • Issued: 07/03/2012
  • Est. Priority Date: 02/03/2005
  • Status: Active Grant
First Claim
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1. An implantable osmotic drug delivery device, comprising:

  • a reservoir containing a stable, nonaqueous suspension formulation, the suspension formulation comprising;

    particles comprising an active agent, a sugar, methionine, and a buffer, wherein the active agent comprises a peptide, polypeptide, or protein; and

    a nonaqueous, single-phase vehicle consisting essentially of about 40% to 60% (w/w) polyvinylpyrrolidone and about 40% to 60% (w/w) benzyl benzoate;

    a piston within the reservoir, the piston separating the suspension formulation from an osmotic engine;

    a semipermeable membrane at a first end of the reservoir adjacent the osmotic engine; and

    a diffusion moderator at a second end of the reservoir adjacent the suspension formulation, the diffusion moderator defining a channel.

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