Method for preparing nano-scale or amorphous particle using solid fat as a solvent
First Claim
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1. A method for preparing nanoscale particles comprising the steps of:
- (1) preparing a mixture comprising one or more active ingredients and solid fat as a solvent in an excess amount to the active ingredient, and(2) pressurizing the mixture comprising one or more active ingredients and solid fat to the critical pressure or more by adding the gas of a supercritical fluid into the mixture, then removing the solid fat from the mixture by releasing out the solid fat together with the gas of the supercritical fluid, wherein the supercritical fluid is CO2 or N2 and wherein the temperature is maintained below the melting point of the solid fat; and
wherein the step (1) comprises adding one or more active ingredients, solid fat and optionally one or more surfactants into a reactor and melt-mixing them homogeneously.
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Abstract
The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.
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Citations
17 Claims
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1. A method for preparing nanoscale particles comprising the steps of:
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(1) preparing a mixture comprising one or more active ingredients and solid fat as a solvent in an excess amount to the active ingredient, and (2) pressurizing the mixture comprising one or more active ingredients and solid fat to the critical pressure or more by adding the gas of a supercritical fluid into the mixture, then removing the solid fat from the mixture by releasing out the solid fat together with the gas of the supercritical fluid, wherein the supercritical fluid is CO2 or N2 and wherein the temperature is maintained below the melting point of the solid fat; and wherein the step (1) comprises adding one or more active ingredients, solid fat and optionally one or more surfactants into a reactor and melt-mixing them homogeneously. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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3. A method for preparing nanoscale particles comprising the steps of:
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(1) preparing a mixture comprising one or more active ingredients and solid fat as a solvent in an excess amount to the active ingredient, and (2) pressurizing the mixture comprising one or more active ingredients and solid fat to the critical pressure or more by adding the gas of a supercritical fluid into the mixture, and then removing the solid fat from the mixture by releasing out the solid fat together with the gas of the supercritical fluid, wherein the supercritical fluid is CO2 or N2 and wherein the temperature is maintained below the melting point of the solid fat, wherein the step (1) comprises;
adding one or more surfactants and solid fat into a reactor, and melt-mixing them homogenously;
rapidly cooling the homogenously melt-mixed mixture for solidification by pouring the mixture into a stainless steel plate which was pre-cooled to 10°
C. or less;
pulverizing the solidified mixture;
adding one or more surfactants and/or one or more non-surfactant type anti-coagulating agents together with one or more active ingredients or aqueous solution thereof, to the pulverized powder and mixing them homogenously; and
drying the mixed product at room temperature.
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Specification