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Method for preparing nano-scale or amorphous particle using solid fat as a solvent

  • US 8,211,470 B2
  • Filed: 11/11/2004
  • Issued: 07/03/2012
  • Est. Priority Date: 12/05/2003
  • Status: Active Grant
First Claim
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1. A method for preparing nanoscale particles comprising the steps of:

  • (1) preparing a mixture comprising one or more active ingredients and solid fat as a solvent in an excess amount to the active ingredient, and(2) pressurizing the mixture comprising one or more active ingredients and solid fat to the critical pressure or more by adding the gas of a supercritical fluid into the mixture, then removing the solid fat from the mixture by releasing out the solid fat together with the gas of the supercritical fluid, wherein the supercritical fluid is CO2 or N2 and wherein the temperature is maintained below the melting point of the solid fat; and

    wherein the step (1) comprises adding one or more active ingredients, solid fat and optionally one or more surfactants into a reactor and melt-mixing them homogeneously.

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