FSTL-1 as a biomaker of inflammation
First Claim
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1. A method for diagnosing systemic juvenile rheumatoid arthritis in an individual comprising:
- (a) measuring the level of protein expression of follistatin-like protein-1 in a biological sample collected from the individual; and
(b) comparing the level of protein expression of follistatin-like protein-1 in the sample from the individual with the level of follistatin-like protein 1 in a healthy subject, where an increased level of follistatin-like protein-1 in the individual sample relative to the healthy subject, wherein the individual exhibits joint swelling, indicates that the individual has a diagnosis of systemic juvenile rheumatoid arthritis.
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Abstract
The invention provides methods and kits for diagnosing severity of particular types of inflammatory diseases, such as rheumatic diseases, by assessing protein levels of follistatin-like protein 1 (FSTL-1). The level of FSTL-1 protein present in the serum or synovial fluid of individuals suspected of having certain inflammatory disease (e.g, rheumatoid arthritis) is positively correlated with the severity of the disease.
16 Citations
4 Claims
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1. A method for diagnosing systemic juvenile rheumatoid arthritis in an individual comprising:
- (a) measuring the level of protein expression of follistatin-like protein-1 in a biological sample collected from the individual; and
(b) comparing the level of protein expression of follistatin-like protein-1 in the sample from the individual with the level of follistatin-like protein 1 in a healthy subject, where an increased level of follistatin-like protein-1 in the individual sample relative to the healthy subject, wherein the individual exhibits joint swelling, indicates that the individual has a diagnosis of systemic juvenile rheumatoid arthritis. - View Dependent Claims (3)
- (a) measuring the level of protein expression of follistatin-like protein-1 in a biological sample collected from the individual; and
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2. A method for diagnosing Kawasaki'"'"'s disease in an individual comprising:
- (a) measuring the level of protein expression of follistatin-like protein-1 in a biological sample collected from the individual; and
(b) comparing the level of protein expression of follistatin-like protein-1 in the sample from the individual with the level of follistatin-like protein 1 in a healthy subject, where an increased level of follistatin-like protein-1 in the individual sample relative to the healthy subject, wherein the individual exhibits one or more symptom selected from the group consisting of eye redness, rash on stomach, chest and genitals, red and dry lips, swollen tongue, coated tongue, sore throat, swollen palms, swollen soles of feet, swollen lymph nodes, and combinations thereof, indicates that the individual has a diagnosis of Kawasaki'"'"'s disease. - View Dependent Claims (4)
- (a) measuring the level of protein expression of follistatin-like protein-1 in a biological sample collected from the individual; and
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Current AssigneeUniversity of Pittsburgh of The Commonwealth System of Higher Education
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Original AssigneeUniversity of Pittsburgh of The Commonwealth System of Higher Education
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InventorsHirsch, Raphael
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Primary Examiner(s)Cheu, Jacob
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Application NumberUS12/864,709Publication NumberTime in Patent Office1,251 DaysField of SearchNoneUS Class Current435/7.1CPC Class CodesG01N 2800/102 Arthritis; Rheumatoid arthr...G01N 2800/26 Infectious diseases, e.g. g...G01N 33/6893 related to diseases not pro...
