Compositions and methods for dry eye syndrome

• US 8,211,942 B2
• Filed: 01/26/2011
• Issued: 07/03/2012
• Est. Priority Date: 06/19/2002
• Status: Expired due to Fees

• Current Assignee: Irvine L. Dubow
• Original Assignee: Irvine L. Dubow
• Inventors: Dubow, Irvine L.
• Primary Examiner(s): FAY, ZOHREH A
• Application Number:
  US13/014,405
• Publication Number:
  US 20110184062A1
• Time in Patent Office: 524 Days
• Field of Search: 514/547, 514/772.3, 514/912
• US Class Current: 514/547
• CPC Class Codes: A61K 31/225 Polycarboxylic acids
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/186 Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

Compositions and methods to inhibit dry eye as well as other conditions are provided.

Claims

1. An ophthalmic composition consisting essentially of:

at least one non-ionic surfactant;

a preservative with reduced immunogenicity relative to thimerosol;

a complexing agent; and

deionized, demineralized, ozonated water.

2. The composition of claim 1 which is non-ionic.

3. The composition of claim 1 further comprising a fatty acid humectant.

4. The composition of claim 3 wherein the fatty acid humectant is glycerin.

5. The composition of claim 4 which comprises about 0.5% to about 1.0% by weight glycerin.

6. The composition of claim 1 further comprising a second surfactant.

7. The composition of claim 6 wherein the second surfactant is Tween 80.

8. The composition of claim 7 which comprises about 0.05% to about 1.0% by weight Tween 80.

9. The composition of claim 1 wherein the preservative is parabens.

10. The composition of claim 9 which comprises about 0.1% to about 2% by weight paraben.

11. The composition of claim 1 wherein the complexing agent is EDTA.

12. The composition of claim 11 which comprises about 0.01% to about 1.0% by weight EDTA.

13. The composition of claim 1 wherein the at least one surfactant is tyloxapol.

14. The composition of claim 13 which comprises about 0.01% to about 1.0% by weight tyloxapol.

15. The composition of claim 1 which is primarily non-ionic.

16. The composition of claim 1 which comprises tyloxapol, parabens and EDTA.

17. The composition of claim 1 which comprises tyloxapol, parabens, EDTA, glycerin and Tween 80.

20. A method to inhibit or treat non-systemic dry eye syndrome, comprising:

contacting an ophthalmic surface with an effective amount of the composition of claim 1.

21. The method of claim 20 wherein the composition comprises tyloxapol, parabens and EDTA.

18. A method of preparing an ophthalmic composition comprising combining a preservative with reduced immunogenicity relative to thimerosol, a complexing agent, at least one non-ionic surfactant, and deionized, demineralized, ozonated water.

19. The method of claim 18 in which tyloxapol, parabens and EDTA are combined.