In vivo localization and tracking of tissue penetrating catheters using magnetic resonance imaging

• US 8,214,015 B2
• Filed: 04/14/2006
• Issued: 07/03/2012
• Est. Priority Date: 02/06/2001
• Status: Active Grant

• Current Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Original Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Inventors: Macaulay, Patrick, Nayak, Asha
• Primary Examiner(s): Cattungal, Sanjay
• Application Number:
  US11/279,773
• Publication Number:
  US 20060184011A1
• Time in Patent Office: 2,272 Days
• Field of Search: 600407-435, 606/130, 606/159, 606/167, 604527-529
• US Class Current: 600/424
• CPC Class Codes: A61B 2034/107 Visualisation of planned trajectories or target regions
• CPC Class Codes: A61B 2034/2051 Electromagnetic tracking systems
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/064 using markers A61B5/062 takes precedence
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61M 2025/0037 characterized by lumina being arranged side-by-side
• CPC Class Codes: A61M 2025/0096 being laterally outward extensions or tools, e.g. hooks or fibres
• CPC Class Codes: A61M 25/0029 characterized by features relating to least one lumen located at the middle part of the catheter, e.g. slots, flaps, valves, cuffs, apertures, notches, grooves or rapid exchange ports catheter shaft surface irregularities A61M2025/006
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/0127 Magnetic means; Magnetic markers
• CPC Class Codes: G01R 33/287 involving active visualization of interventional instruments, e.g. using active tracking RF coils or coils for intentionally creating magnetic field inhomogeneities

Abstract

Magnetic resonance image (MRI) guided tissue penetrating catheters and their methods of use. One or more MRI apparatus (e.g., one or more coils) are positioned on or in a catheter device that includes a tissue penetrator that may be used to form a penetration tract from a body lumen in which the catheter is positioned to a target location outside of that body lumen. The MRI apparatus (e.g., coil(s)) is/are used in conjunction with an MRI imaging system to indicate the position and/or rotational orientation of the penetrating catheter within the subject'"'"'s body.

Claims

1. A tissue penetrating catheter device useable with a magnetic resonance imaging system, said device comprising:

a catheter body having a distal end;

a tissue penetrator that is advanceable from the catheter body; and

at least one magnetic resonance apparatus that sends signals to a magnetic resonance imaging system adapted to use said signals to provide an indication of the position of said at least one magnetic resonance apparatus;

wherein said at least one magnetic resonance apparatus comprises a first magnetic resonance apparatus located at a first location on or in the catheter body at or near the distal end of the catheter body, a second magnetic resonance apparatus located at a second location situated on or in the penetrator and a third magnetic resonance apparatus located at a third location on or in the catheter body at or near a location where the tissue penetrator advances out of the catheter body.

2. A device according to claim 1 wherein said at least one magnetic resonance apparatus comprises at least one coil.

3. A device according to claim 1 wherein said at least one magnetic resonance apparatus comprises at least one magnetic resonance receiver.

4. A device according to claim 1 wherein a magnetic resonance apparatus is located on or in the catheter body.

5. A device according to claim 1 wherein a magnetic resonance apparatus is located on or in the penetrator.

6. A device according to claim 1 wherein a first magnetic resonance apparatus is located on or in the catheter body and a second magnetic resonance apparatus is located on or in the penetrator.

7. A device according to claim 1 wherein the tissue penetrator comprises an elongate member having a lumen.

8. A device according to claim 1 wherein the tissue penetrator comprises a needle.

9. A device according to claim 1 wherein said at least one magnetic resonance apparatus comprises at least one antenna.

10. A device according to claim 4 wherein said at least one magnetic resonance apparatus comprises at least one loopless antenna.

11. A device according to claim 1 wherein the tissue penetrator comprises an elongate penetration member and wherein the device further comprises a penetrator housing within which at least a portion of the elongate penetration member resides when in its retracted position.

12. A device according to claim 11 wherein a first magnetic resonance apparatus is located at or near the distal end of the catheter body, a second magnetic resonance apparatus is located on or in the penetrator member and a third magnetic resonance apparatus is located on, in or adjacent to the penetrator housing.

13. A device according to claim 11 wherein a magnetic resonance apparatus is located on, in or adjacent to the penetrator housing.

14. A device according to claim 13 wherein the penetrator housing comprises a tubular penetrator housing and wherein a magnetic resonance apparatus comprises a coil that substantially surrounds the tubular penetrator housing.

15. A device according to either of claim 11 or 13 wherein the penetrator exits from a side opening in the catheter body and the penetrator housing is curved in the direction of sad side opening.

16. A device according to claim 15 wherein a magnetic resonance apparatus is positioned on, in or adjacent to the curved penetrator housing such that it provides an image of the penetrator housing.

17. A device according to claim 16 wherein the penetrator housing is shaped such that a portion of the penetrator housing is in alignment with the trajectory on which the penetrator will advance from the catheter body, the image of the penetrator housing being thereby generally useable as an indication of the trajectory on which the penetrator will advance from the catheter body.

18. A device according to claim 1 wherein the tissue penetrator has a lumen through which a substance, article or device may be delivered.

19. A system comprising a device according to claim 18 in combination with substance delivery apparatus useable to deliver a substance through the lumen of the tissue penetrator.

20. A system comprising a device according to claim 18 in combination with a catheter that is advanceable through the lumen of the tissue penetrator.

21. A system according to claim 20 wherein the catheter that is advanceable through the lumen of the tissue penetrator comprises a microcatheter.

22. A system comprising a device according to claim 18 in combination with a device that is advanceable through the lumen of the tissue penetrator.

23. A system according to claim 22 wherein the device that is advanceable through the lumen of the tissue penetrator comprises a guidewire.

24. A system according to claim 1 in combination with a magnetic resonance system that is programmed to receive signals from the at least one magnetic resonance apparatus and to display the location of the at least one magnetic resonance apparatus in response to said signals.

25. A system according to claim 24 wherein the magnetic resonance system displays the location of the at least one magnetic resonance apparatus in relation to images of anatomical structures located near the current position of the at least one magnetic resonance apparatus.

26. A system according to claim 24 wherein the location of the at least one magnetic resonance apparatus is superimposed on an anatomical image.

27. A system according to claim 24 wherein the tissue penetrating catheter device includes a plurality of magnetic resonance apparatus and wherein the magnetic resonance system displays a different indicator for the position of each magnetic resonance apparatus.

28. A system according to claim 27 wherein the magnetic resonance system displays a different colored indicator for the location of each magnetic resonance apparatus.

29. A system according to claim 24 wherein the magnetic resonance system receives signals from the at least one magnetic resonance apparatus defining the rotational orientation of the tissue penetrating catheter device and in response to said signals displays an indication of the rotational orientation of the tissue penetrating catheter device.