Method and apparatus for delivering an agent to a kidney

• US 8,216,209 B2
• Filed: 05/31/2007
• Issued: 07/10/2012
• Est. Priority Date: 05/31/2007
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Consigny, Paul M., El-Nounou, Fozan O., Gale, David C., Kramer-Brown, Pamela A.
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): Scott, Brandy C
• Application Number:
  US11/756,376
• Publication Number:
  US 20080300573A1
• Time in Patent Office: 1,867 Days
• Field of Search: 604/509, 604/103.09, 604/508, 604/510, 604/103.01
• US Class Current: 604/509
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61L 2300/40 characterised by a specific therapeutic activity or mode of action
• CPC Class Codes: A61L 2300/432 Inhibitors, antagonists A61L2300/402 - A61L2300/43 take precedence
• CPC Class Codes: A61L 2300/62 Encapsulated active agents, e.g. emulsified droplets
• CPC Class Codes: A61L 2430/26 for kidney reconstruction
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow general flow characteristics A61M2206/10
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 25/04 in the body, e.g. expansible A61M25/10, A61M16/0488 take precedence
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.

Claims

1. A method comprising:

introducing a delivery device to a point within a renal artery, the delivery device comprising a primary cannula having a first end, a second end and a medial region between the first end and the second end, wherein the first end comprises a first port and a second port, the medial region comprises at least one longitudinally disposed aperture in fluid communication with the first port such that blood flowing toward the renal artery flows into the primary cannula through the aperture and out the first port to the renal artery, and the second port is adapted for advancing a guidewire there through; and

delivering a treatment agent along with the blood flowing through the primary cannula from the first port to create a turbulent blood flow into the kidney in addition to any turbulent conditions from the presence of the delivery device in the renal artery, wherein said treatment agent is capable of inhibiting a biological process contributing to nephropathy.

2. The method of claim 1 wherein the first end of the delivery device is positioned within the renal artery and the aperture is positioned within an aorta such that the blood flowing from the aorta is diverted through the aperture and into the primary cannula.

3. The method of claim 1 wherein the treatment agent is mixed with the blood flowing through the primary cannula prior to delivering the treatment agent from the first port.