Drug delivery from electroactive molecularly imprinted polymer

• US 8,216,300 B2
• Filed: 11/06/2008
• Issued: 07/10/2012
• Est. Priority Date: 03/12/2005
• Status: Active Grant

• Current Assignee: Saint Louis University
• Original Assignee: Saint Louis University
• Inventors: Minteer, Shelley D., Ulyanova, Jenny
• Primary Examiner(s): Weber, Jon P
• Assistant Examiner(s): UNDERDAHL, THANE E
• Application Number:
  US12/266,349
• Publication Number:
  US 20090076437A1
• Time in Patent Office: 1,342 Days
• Field of Search: 623/1.42, 252/301.25, 424/78.22
• US Class Current: 623/1.42
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: H01M 8/16 Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts
• CPC Class Codes: Y02E 60/50 Fuel cells

Abstract

A device delivers a chemical or biological agent, the device comprises an imprint molecule (IM) to be delivered by the device; an electroactive molecularly imprinted polymer (EMIP) imprinted with the imprint molecule, the EMIP having a plurality of binding sites capable of binding the imprint; and an electric potential producing member (EPM), the EPM being capable of producing an electric potential between the EPM and the EMIP; whereby when the EMIP has a predetermined density of imprint molecule bound at the binding sites, and whereby when a sufficient potential is produced between the EPM and the EMIP, the imprint molecule is released from the binding site and thereby delivered by the device.

Claims

1. A device for delivery of a chemical or biological agent comprising:

a first imprint molecule comprising said chemical or biological agent to be delivered by said device;

a first electroactive molecularly imprinted polymer imprinted with said first imprint molecule, said first electroactive molecularly imprinted polymer also having a plurality of binding sites capable of binding said first imprint molecule, said binding sites characterized by a binding affinity between said binding site and said first imprint molecule; and

an electric potential producing member, said electric potential producing member capable of creating an electric potential between said electric potential producing member and said first electroactive molecularly imprinted polymer;

wherein said first electroactive molecularly imprinted polymer has a predetermined density of said first imprint molecule bound at said binding sites;

wherein when a sufficient potential is produced between said electric potential producing member and said first electroactive molecularly imprinted polymer, said binding affinity between said binding site and said first imprint molecule is decreased so that said first imprint molecule is released from said binding site and thereby delivered by said device; and

wherein said first electroactive molecularly imprinted polymer is of the class termed polyazine.

2. The device of claim 1 wherein said electric potential producing member comprises an electroactive sensing element that alters said potential between said electric potential producing member and said first electroactive molecularly imprinted polymer based on the presence of an analyte.

3. The device of claim 2:

wherein said electroactive sensing element is a second electroactive molecularly imprinted polymer imprinted with a second imprint molecule and having a plurality of binding sites, each binding site being capable of binding said second imprint molecule in a manner characterized by a certain binding affinity between said binding site and said second imprint molecule;

wherein the binding of said second imprint molecule in said binding site alters said potential; and

wherein said second imprint molecule comprises said analyte.

4. The device of claim 2, wherein said means for creating electric potential is a biofuel cell.

5. The device of claim 1, wherein said binding sites are capable of transitioning between at least a first electroconformation and a second electroconformation, and wherein said binding affinity between said first imprint molecule and said binding site existing in said first electroconformation is greater than said binding affinity between said first imprint molecule and said binding site existing in said second electroconformation, and wherein said sufficient potential produced between said electric potential producing member and said first electroactive molecularly imprinted polymer results in said transition of said binding site between said first electroconformation and said second electroconformation.

6. The device of claim 1, wherein said first imprint molecule is capable of transitioning between at least a first electroconformation and a second electroconformation, and wherein said binding affinity between said binding site and said first imprint molecule existing in said first electroconformation is greater than said binding affinity between said binding site and said first imprint molecule existing in said second electroconformation, and wherein said sufficient potential produced between said electric potential producing member and said first electroactive molecularly imprinted polymer results in said transition of said first imprint molecule between said first electroconformation and said second electroconformation.

7. The device of claim 1, wherein said first electroactive molecularly imprinted polymer is capable of participating in electron transfer.

8. The device of claim 1, wherein said first electroactive molecularly imprinted polymer is capable of undergoing a redox reaction at said binding site.

9. The device of claim 1, wherein said first electroactive molecularly imprinted polymer is a conducting polymer.

10. The device of claim 1, wherein said electric potential producing member is selected from the group consisting of a potentiometer, a biofuel cell, and an electroactive molecularly imprinted polymer.

11. A device for delivery of a chemical or biological agent comprising:

a first imprint molecule comprising said chemical or biological agent to be delivered by said device;

a first electroactive molecularly imprinted polymer imprinted with said first imprint molecule, said first electroactive molecularly imprinted polymer also having a plurality of binding sites capable of binding said first imprint molecule, said binding sites characterized by a binding affinity between said binding site and said first imprint molecule; and

an electric potential producing member, said electric potential producing member capable of creating an electric potential between said electric potential producing member and said first electroactive molecularly imprinted polymer;

wherein said first electroactive molecularly imprinted polymer has a predetermined density of said first imprint molecule bound at said binding sites;

wherein when a sufficient potential is produced between said electric potential producing member and said first electroactive molecularly imprinted polymer, said binding affinity between said binding site and said first imprint molecule is decreased so that said first imprint molecule is released from said binding site and thereby delivered by said device; and

wherein said electroactive molecularly imprinted polymer is one of poly(methylene green), poly(methylene blue), or poly(neutral red).

12. The device of claim 11 wherein said electric potential producing member comprises an electroactive sensing element that alters said potential between said electric potential producing member and said first electroactive molecularly imprinted polymer based on the presence of an analyte.

13. The device of claim 12:

wherein said electroactive sensing element is a second electroactive molecularly imprinted polymer imprinted with a second imprint molecule and having a plurality of binding sites, each binding site being capable of binding said second imprint molecule in a manner characterized by a certain binding affinity between said binding site and said second imprint molecule;

wherein the binding of said second imprint molecule in said binding site alters said potential; and

wherein said second imprint molecule comprises said analyte.

14. The device of claim 12, wherein said means for creating electric potential is a biofuel cell.

15. The device of claim 11, wherein said binding sites are capable of transitioning between at least a first electroconformation and a second electroconformation, and wherein said binding affinity between said first imprint molecule and said binding site existing in said first electroconformation is greater than said binding affinity between said first imprint molecule and said binding site existing in said second electroconformation, and wherein said sufficient potential produced between said electric potential producing member and said first electroactive molecularly imprinted polymer results in said transition of said binding site between said first electroconformation and said second electroconformation.

16. The device of claim 11, wherein said first imprint molecule is capable of transitioning between at least a first electroconformation and a second electroconformation, and wherein said binding affinity between said binding site and said first imprint molecule existing in said first electroconformation is greater than said binding affinity between said binding site and said first imprint molecule existing in said second electroconformation, and wherein said sufficient potential produced between said electric potential producing member and said first electroactive molecularly imprinted polymer results in said transition of said first imprint molecule between said first electroconformation and said second electroconformation.

17. The device of claim 11, wherein said first electroactive molecularly imprinted polymer is capable of participating in electron transfer.

18. The device of claim 11, wherein said first electroactive molecularly imprinted polymer is capable of undergoing a redox reaction at said binding site.

19. The device of claim 11, wherein said first electroactive molecularly imprinted polymer is a conducting polymer.

20. The device of claim 11, wherein said electric potential producing member is selected from the group consisting of a potentiometer, a biofuel cell, and an electroactive molecularly imprinted polymer.