Delayed-setting calcium phosphate pastes
First Claim
1. A paste comprising a calcium phosphate material in an amount of at least 55% (w/w) and a non-aqueous liquid, in an amount of 5% to 20% (w/w), selected from dimethyl sulfoxide, N-methyl 2-pyrrolidone, glycofurol, ethyl lactate, ethanol, 1,2-dimethoxyethane, diglyme, dimethyl isosorbide, tetrahydrofurfuryl alcohol, triacetin, propylene carbonate, lecithin, and combinations thereof, wherein said paste comprises less than 5% (w/w) water and said paste forms a hardened poorly crystalline apatitic (PCA) calcium phosphate material when said non-aqueous liquid diffuses from said paste.
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Accused Products
Abstract
The invention features delayed-setting calcium phosphate pastes which are useful for the preparation of delivery vehicles for biologically active agents, useful for the treatment of orthopedic conditions and can be stored for long periods without prematurely setting.
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Citations
33 Claims
- 1. A paste comprising a calcium phosphate material in an amount of at least 55% (w/w) and a non-aqueous liquid, in an amount of 5% to 20% (w/w), selected from dimethyl sulfoxide, N-methyl 2-pyrrolidone, glycofurol, ethyl lactate, ethanol, 1,2-dimethoxyethane, diglyme, dimethyl isosorbide, tetrahydrofurfuryl alcohol, triacetin, propylene carbonate, lecithin, and combinations thereof, wherein said paste comprises less than 5% (w/w) water and said paste forms a hardened poorly crystalline apatitic (PCA) calcium phosphate material when said non-aqueous liquid diffuses from said paste.
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23. A method of preparing an implant, comprising:
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(i) preparing a paste comprising a calcium phosphate material in an amount of at least 55% (w/w) and a non-aqueous liquid in an amount of 5% to 20% (w/w), wherein said non-aqueous liquid is selected from dimethyl sulfoxide, N-methyl 2-pyrrolidone, glycofurol, ethyl lactate, ethanol, 1,2- dimethoxyethane, diglyme, dimethyl isosorbide, tetrahydrofurfuryl alcohol, triacetin, propylene carbonate, lecithin, and combinations thereof and wherein said paste comprises less than 5% (w/w) water, and (ii) allowing said paste to form a hardened poorly crystalline apatitic (PCA) calcium phosphate material when said non-aqueous liquid diffuses from said paste. - View Dependent Claims (24, 25, 26)
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Specification