Endoprosthesis coating

• US 8,216,632 B2
• Filed: 11/02/2007
• Issued: 07/10/2012
• Est. Priority Date: 11/02/2007
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Schoenle, Victor, Schewe, Scott R., Radhakrishnan, Rajesh
• Primary Examiner(s): LEE, DORIS L
• Application Number:
  US11/934,435
• Publication Number:
  US 20090118814A1
• Time in Patent Office: 1,712 Days
• Field of Search: 427/2.4
• US Class Current: 427/2.25
• CPC Class Codes: A61L 31/082 Inorganic materials
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 33/00 Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
• CPC Class Codes: C23C 14/025 Metallic sublayers
• CPC Class Codes: C23C 14/046 Coating cavities or hollow spaces, e.g. interior of tubes; Infiltration of porous substrates
• CPC Class Codes: C23C 14/08 Oxides C23C14/10 takes precedence
• CPC Class Codes: C23C 14/3464 using more than one target C23C14/56 takes precedence
• CPC Class Codes: C23C 14/352 using more than one target C23C14/56 takes precedence

Abstract

A method includes: providing a tubular substrate in a chamber, the tubular substrate having a lumen, an a luminal surface and a luminal surface; providing a target in the lumen; depositing a first coating onto the abluminal surface and a second coating onto the luminal surface while keeping the tubular substrate in the chamber. An endoprosthesis, such as a stent, including a first coating on at least one portion of its abluminal surface and a second coating on at least one portion of its luminal surface is also disclosed.

Claims

1. A method of forming an endoprosthesis, comprising:

providing in a deposition chamber a substrate having a first surface and a second surface opposite the first surface, the substrate being a tubular substrate, the first surface being an abluminal surface of the tubular substrate, and the second surface being a luminal surface of the tubular substrate;

providing a first target and a second target in the chamber, the second target being in a lumen of the tubular substrate and the first target being outside the lumen of the tubular substrate;

depositing material from the first target onto the first surface and material from the second target onto the second surface without removing the substrate from the chamber, and

utilizing the substrate in an endoprosthesis.

2. The method of claim 1 wherein the material from the first target and the material from the second target are deposited by physical vapor deposition.

3. The method of claim 1 wherein the first target has a different composition than the second target.

4. The method of claim 1 wherein the second target has different compositions in different regions.

5. The method of claim 1 wherein the second target extends along an axis of the lumen, and the second target has a variable shape along its axial extension.

6. The method of claim 2 wherein depositing by the physical vapor deposition comprises controlling a power on the substrate and first target.

7. The method of claim 6 wherein depositing the material from the first target and the material from the second target comprises simultaneously depositing the material from the first target and the material from the second target onto the first surface and the second surface.

8. The method of claim 6 or 7 wherein the deposited material from the first target and the deposited material from the second target form ceramic coatings on the first surface and the second surface.

9. The method of claim 8 wherein the ceramic coating on the first surface and the ceramic coating on the second surface have different morphologies.

10. The method of claim 9 wherein the ceramic coating on the first surface has a defined grain morphology.

11. The method of claim 10 wherein the ceramic coating on the second surface has a globular morphology.

12. The method of claim 11 wherein the ceramic coatings comprise a ceramic material selected from oxides and nitrides of iridium, zirconium, titanium, hafnium, niobium, tantalum, ruthenium, platinum and aluminum.

13. The method of claim 12 wherein the ceramic material is iridium oxide.

14. The method of claim 4 wherein the second target extends along an axis of the lumen and the different regions are at different axial locations.

15. The method of claim 5 wherein the second target is wider near the end regions of the tubular substrate.