Method of making a micro-channel array device

• US 8,216,980 B2
• Filed: 08/08/2005
• Issued: 07/10/2012
• Est. Priority Date: 12/13/2000
• Status: Expired due to Fees

• Current Assignee: Polymicro Technologies LLC (KOCH Industries Incorporated)
• Original Assignee: Polymicro Technologies LLC (KOCH Industries Incorporated)
• Inventors: Clarkin, James P., Nelson, Gary W., Macomber, Robert J.
• Primary Examiner(s): Steele, Amber D.
• Application Number:
  US11/198,172
• Publication Number:
  US 20050287047A1
• Time in Patent Office: 2,528 Days
• Field of Search: None
• US Class Current: 506/33
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/0654 Lenses; Optical fibres
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B81B 1/002 Holes characterised by their shape, in either longitudinal or sectional plane
• CPC Class Codes: B81B 2201/058 Microfluidics not provided for in B81B2201/051 - B81B2201/054
• CPC Class Codes: G01N 27/44721 by optical means

Abstract

Micro channel array devices drawn from a bulk preform having an array of components to reduce the cross section. The reduced cross section fiber like structure is cut to produce individual arrays of small scale. End caps are drawn and optionally micro machined. The end caps are used to provide input and output ports and other structures for use with the micro channel arrays. A micro channel array may be used with different end caps for analysis and may form a lab on a chip or a component thereof.

Claims

1. A method of making a device for analyzing a plurality of sample components, comprising, in order:

forming at least two hollow channels in a preform substrate along a length of said preform substrate;

heating said preform substrate including said at least two hollow channels; and

drawing said preform substrate along said length so as to extend a length of said at least two hollow channels while substantially maintaining a cross sectional geometry of said at least two hollow channels, wherein a cross-sectional area of at least one of the at least two hollow channels is in the range of 0.0001 mm² to 1 mm² after said drawing.

2. The method of claim 1, wherein the length of at least one of said at least two hollow channels after said drawing is in the range of 1 mm to 1 km.

3. The method of claim 1, wherein, subsequently to said drawing, the preform substrate is utilized in a micro electro mechanical system.

4. The method of claim 1, wherein, subsequently to said drawing, the preform substrate is utilized in a lab on a chip system.

5. The method of claim 1, further comprising adjusting one or more of draw rate, draw tensions, draw temperature, and draw pressure to vary a cross-sectional area of said at least two hollow channels along the length of said preform.

6. The method of claim 1, wherein said preform substrate includes an optical waveguide formed therein and extending in a direction parallel to the length of said preform.

7. (The method of claim 1, wherein said preform substrate further comprises an electrical conductor extending in the direction parallel to the length of said preform.

8. The method of claim 1, wherein the preform substrate further comprises at least one optical isolator extending in the direction parallel to the length of said preform.

9. The method of claim 1, wherein the cross-sectional geometry of a first one of the at least two hollow channels after said drawing is different from the cross-sectional geometry of a second one of the at least two drawn channels.

10. The method of claim 1, wherein the preform substrate comprises a material selected from the group comprising:

glass, ceramic, and thermoplastic polymers.

11. The method of claim 1, wherein the preform substrate comprises a material selected from the group comprising:

fused silica, fused quartz, and PMMA.

12. The method of claim 1, further comprising providing the preform substrate with an exterior coating comprising a material selected from the group consisting of polyimide, acrylate, fluorinated acrylate, silicone, metal, and optical cladding.

13. The method of claim 1, further comprising, after said drawing, providing the drawn preformsubstrate with an exterior coating comprising a material selected from the group consisting of magnetic, radio opaque, optically filtering, conductive, and dielectric.

14. The method of claim 1, further comprising providing the preform substrate with an interior coating comprising a material selected from the group consisting of hydrophobic bonded phases, hydrophyllic bonded phases, polyacrlyarnides, silver, silver halide, gold, and polytetrafluoroethylene.

15. The method of claim 1, wherein at least a selected one of the at least two hollow channels after said drawing has at least of a portion of a wall comprising a lens.

16. The method of claim 1, wherein at least a selected one of the at least two hollow channels after said drawing has at least a portion of a wall comprising a reflector.

17. The method of claim 1, wherein the preform substrate after said drawing has at least one alignment groove on its exterior surface, down its length.

18. The method of claim 1, wherein said preform substrate further includes an optical fiber interfaced into one of the hollow channels.

19. The method of claim 18, wherein said preform substrate further includes a structure for redirecting light in the hollow channel interfaced with the optical fiber.

20. The method of claim 19, wherein the structure for redirecting light comprises a reflecting surface located on the end of the optical fiber interfaced into the hollow channel.

21. The method of claim 20, wherein after said drawing the at least two hollow channels have a substantially constant spacing therebetween, a substantially constant relative rotational alignment and a substantially constant relative angular alignment along the length of the substrate.

22. The method of claim 20, wherein two of the hollow channels after said drawing have a portion of a wall comprising a lens and the two lenses have a substantially constant spacing therebetween, a substantially constant relative rotational alignment and a substantially constant relative angular alignment along the length of the substrate.

23. The method of claim 1, further comprising cutting said perform substrate after said drawing to a desired length.

24. The method of claim 1, further comprising attaching at least one endcap substrate having at least one endcap channel to said preform substrate after said drawing, said at least one endcap channel being in fluid communication with at least one hollow channel.

25. The method of claim 24, wherein said endcap channel is in fluid communication with said at least two hollow channels.

26. The method of claim 24, wherein said attaching comprises heating said endcap substrate and drawing said endcap substrate so as to extend a length of said at least one endcap channel while substantially maintaining a cross sectional geometry of said at least one endcap channel.

27. The method of claim 24, wherein said endcap substrate comprises an endcap channel having a cross-sectional geometry different from a cross-sectional geometry of the at least one endcap channel.

28. The method of claim 24, wherein said at least one endcap channel has at least a portion of a wall comprising a lens.

29. The method of claim 24, wherein said at least one endcap channel has at least a portion of a wall comprising a reflector.

30. The method of claim 24, wherein said at least one endcap substrate has at least one alignment groove on its exterior surface.

31. The method of claim 24, wherein another endcap channel and said at least one endcap channel have a substantially constant spacing therebetween, a substantially constant relative rotational alignment and a substantially constant relative angular alignment along a length of the endcap substrate.

32. The method of claim 1, wherein forming said at least two hollow channels comprises machining the preform substrate.

33. The method of claim 1, wherein forming said at least two hollow channels comprises etching the preform substrate.