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Multimer of extracellular domain of cell surface functional molecule

  • US 8,216,996 B2
  • Filed: 03/02/2007
  • Issued: 07/10/2012
  • Est. Priority Date: 03/03/2006
  • Status: Active Grant
First Claim
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1. A multimer comprising four extracellular domains of Programmed Cell Death-1 (PD-1), wherein each of said four extracellular domains comprise a region selected from (a) and (b):

  • (a) residues 1-167 or residues 25-145 of full-length human PD-1, wherein the cysteine at position 93 is substituted by serine; and

    (b) residues 1-169 or residues 25-145 of full-length mouse PD-1, wherein the cysteine at position 83 is substituted by serine,and wherein said four extracellular domains are (i) serially-concatenated directly or with a peptide linker, or (ii) bound to a carrier via a non-peptide linker.

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