Chemical compounds
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Abstract
The present invention features compounds that are prodrugs of HIIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
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Citations
10 Claims
- 1. A compound of formula (I):
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6. A compound selected from the group consisting of:
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{[(4R,12aS)-9-({[(2,4-Difluorophenyl)methyl]amino}carbonyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′
,2′
;
4,5]pyrazino[2,1-b][1,3]oxazin-7-yl]oxy}methyl methyl carbonate;{[(4R,12aS)-9-({[(2,4-Difluorophenyl)methyl]amino}carbonyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′
,2′
;
4,5]pyrazino[2,1-b][1,3]oxazin-7-yl]oxy}methyl 2-(methyloxy)ethyl carbonate;{[(4R,12aS)-9-({[(2,4-Difluorophenyl)methyl]amino}carbonyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′
,2′
;
4,5]pyrazino[2,1-b][1,3]oxazin-7-yl]oxy}methyl 2-hydroxyethyl carbonate;{[(4R,12aS)-9-({[(2,4-Difluorophenyl)methyl]amino}carbonyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′
,2′
;
4,5]pyrazino[2,1-b][1,3]oxazin-7-yl]oxy}methyl 2-(phosphonooxy)ethyl carbonate;{[(4R,12aS)-9-({[(2,4-Difluorophenyl)methyl]amino}carbonyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′
,2′
;
4,5]pyrazino[2,1-b][1,3]oxazin-7-yl]oxy}methyl 2-(4-morpholinyl)ethyl carbonate; andpharmaceutically acceptable salts thereof.
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Specification