Synchronization of vagus nerve stimulation with the cardiac cycle of a patient
First Claim
1. A method of treating a medical condition of a patient having a vagus nerve and a brain using a medical device, the method comprising:
- detecting at least a portion of a physiological cycle of the patient, the physiological cycle comprising a cardiac cycle of the patient; and
applying a first electrical signal to a portion of the vagus nerve of the patient through an electrode assembly at a selected point in the physiological cycle, the first electrical signal comprising a plurality of microbursts, each microburst comprising a plurality of pulses, adjacent ones of the plurality of pulses being separated by an interpulse interval, adjacent ones of the plurality of microbursts being separated by an interburst period, the first electrical signal generating vagal afferent activity or augmenting endogenous vagal afferent activity on the vagus nerve conducted to the brain of the patient by the vagus nerve to thereby treat the medical condition,wherein the selected point in the physiological cycle relates to a point in the physiological cycle of the patient when the application of the first electrical signal increases heart rate variability, and wherein the selected point in the physiological cycle is not correlated with increased efferent conduction on the vagus nerve of the patient.
1 Assignment
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Accused Products
Abstract
Methods, systems, and apparatus for treating a medical condition of a patient, involving detecting a physiological cycle or cycles of the patient and applying an electrical signal to a portion of the patient'"'"'s vagus nerve through an electrode at a selected point in the physiological cycle(s). The physiological cycle can be the cardiac and/or respiratory cycle. The selected point can be a point in the cardiac cycle correlated with increased afferent conduction on the vagus nerve, such as a point from about 10 msec to about 800 msec after an R-wave of the patient'"'"'s ECG, optionally during inspiration by the patient. The selected point can be a point in the cardiac cycle when said applying increases heart rate variability, such as a point from about 10 msec to about 800 msec after an R-wave of the patient'"'"'s ECG, optionally during expiration by the patient.
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Citations
29 Claims
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1. A method of treating a medical condition of a patient having a vagus nerve and a brain using a medical device, the method comprising:
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detecting at least a portion of a physiological cycle of the patient, the physiological cycle comprising a cardiac cycle of the patient; and applying a first electrical signal to a portion of the vagus nerve of the patient through an electrode assembly at a selected point in the physiological cycle, the first electrical signal comprising a plurality of microbursts, each microburst comprising a plurality of pulses, adjacent ones of the plurality of pulses being separated by an interpulse interval, adjacent ones of the plurality of microbursts being separated by an interburst period, the first electrical signal generating vagal afferent activity or augmenting endogenous vagal afferent activity on the vagus nerve conducted to the brain of the patient by the vagus nerve to thereby treat the medical condition, wherein the selected point in the physiological cycle relates to a point in the physiological cycle of the patient when the application of the first electrical signal increases heart rate variability, and wherein the selected point in the physiological cycle is not correlated with increased efferent conduction on the vagus nerve of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of treating a medical condition of a patient having at least one vagus nerve and a brain, the method comprising:
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coupling at least one electrode to the at least one vagus nerve of the patient; providing a programmable electrical signal generator coupled to the at least one electrode; detecting at least a portion of a physiological cycle of the patient, the physiological cycle comprising the cardiac cycle of the patient; generating an electrical signal with the electrical signal generator, the electrical signal comprising a plurality of microbursts, each microburst comprising a plurality of pulses, adjacent ones of the plurality of pulses being separated by an interpulse interval, adjacent ones of the plurality of microbursts being separated by an interburst period; and applying the electrical signal to the at least one electrode at a selected point in the physiological cycle to treat the medical condition, the electrical signal generating vagal afferent activity or augmenting endogenous vagal afferent activity on the at least one vagus nerve that is conducted to the brain of the patient by the at least one vagus nerve to treat the medical condition; wherein the selected point in the physiological cycle relates to a point in the physiological cycle of the patient when the application of the electrical signal increases heart rate variability, and wherein the selected point in the physiological cycle is not correlated with increased efferent conduction on the vagus nerve of the patient.
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14. A medical condition treatment system comprising:
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at least one electrode adapted to be coupled to at least one vagus nerve of a patient having a brain;
.an implantable device operatively coupled to the at least one electrode and comprising an electrical signal generator capable of applying one or more electrical signals to the at least one vagus nerve at a selected point in a physiological cycle comprising a cardiac cycle of the patient, each electrical signal comprising a plurality of microbursts, each microburst comprising a plurality of pulses, adjacent ones of the plurality of pulses being separated by an interpulse interval, adjacent ones of the plurality of microbursts being separated by an interburst period, each electrical signal being configured to generate vagal afferent activity or augment endogenous vagal afferent activity on the at least one vagus nerve that is conducted to the brain of the patient by the at least one vagus nerve to treat the medical condition, wherein the selected point in the physiological cycle relates to a point in the physiological cycle of the patient when the application of the electrical signal increases heart rate variability, and wherein the selected point in the physiological cycle is not correlated with increased efferent conduction on the vagus nerve of the patient; and a device configured to detect the selected point in the patient'"'"'s physiological cycle operatively coupled to the at least one electrode. - View Dependent Claims (15, 16, 17, 18, 19)
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20. A method of treating a brain disorder of a patient having a vagus nerve, the method comprising:
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detecting at least a portion of a physiological cycle of the patient, the physiological cycle comprising a cardiac cycle of the patient; and applying a first electrical signal to a portion of the vagus nerve of the patient through an electrode assembly at a selected point in the physiological cycle, the first electrical signal comprising a plurality of microbursts, each microburst comprising a plurality of pulses, adjacent ones of the plurality of pulses being separated by an interpulse interval, adjacent ones of the plurality of microbursts being separated by an interburst period, the first electrical signal generating vagal afferent activity or augmenting endogenous vagal afferent activity on the vagus nerve conducted to the brain of the patient by the vagus nerve to thereby treat the brain disorder, wherein the selected point in the physiological cycle relates to a point in the physiological cycle of the patient when the application of the first electrical signal increases heart rate variability. - View Dependent Claims (21, 22, 23, 24, 25)
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26. A system for treating a brain disorder of a patient having at least one vagus nerve, comprising:
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at least one electrode configured for operative coupling to the at least one vagus nerve of the patient; an implantable device operatively coupled to the at least one electrode and comprising an electrical signal generator capable of applying one or more electrical signals to the at least one vagus nerve at a selected point in a physiological cycle comprising a cardiac cycle of the patient, each electrical signal comprising a plurality of microbursts, each microburst comprising a plurality of pulses, adjacent ones of the plurality of pulses being separated by an interpulse interval, adjacent ones of the plurality of microbursts being separated by an interburst period, each electrical signal being configured to generate vagal afferent activity or augment endogenous vagal afferent activity on the at least one vagus nerve that is conducted to the brain of the patient by the at least one vagus nerve to treat the brain disorder, wherein the selected point in the physiological cycle relates to a point in the physiological cycle of the patient when the application of the electrical signal increases heart rate variability; and a device configured to detect the selected point in the patient'"'"'s physiological cycle, wherein the device is operatively coupled to the at least one electrode. - View Dependent Claims (27, 28, 29)
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Specification