Smooth muscle controller for controlling the level of a chemical in the blood stream

• US 8,219,201 B2
• Filed: 04/17/2007
• Issued: 07/10/2012
• Est. Priority Date: 07/16/1997
• Status: Expired due to Fees

• Current Assignee: Tylerton International Inc.
• Original Assignee: MetaCure Limited (MetaCure (USA), Inc.)
• Inventors: Ben-Haim, Shlomo, Darvish, Nissim, Mika, Yuval, Fenster, Maier, Felzen, Bella, Shemer, Isaac
• Primary Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US11/736,183
• Publication Number:
  US 20070185540A1
• Time in Patent Office: 1,911 Days
• Field of Search: None
• US Class Current: 607/40
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/20 continuous direct currents
• CPC Class Codes: A61N 1/205 for promoting a biological process
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators

Abstract

An apparatus that comprises at least one electrode adapted to be placed adjacent to a portion of smooth muscle (200) and a controller for electrifying the electrode with a non-excitatory electric field (210) which does not generate excitation of the smooth muscle. The non-excitatory electric field affects the activity of the smooth muscle in a manner that controls a level of a chemical in the blood stream.

Claims

1. Apparatus comprising:

at least one implantable electrode adapted to be placed adjacent to a portion of smooth muscle; and

a controller for electrifying said implantable electrode with a non-excitatory electric field which does not generate excitation of said smooth muscle, wherein said non-excitatory electric field affects the activity of said smooth muscle in a manner that controls a level of a chemical in the blood stream.

2. The apparatus according to claim 1, comprising a sensor for measuring a level of said chemical in a blood stream.

3. The apparatus according to claim 2, wherein said controller electrifies said implantable electrode with said non-excitatory electric field, responsive to the measured level.

4. The apparatus according to claim 3, wherein said chemical is glucose.

5. The apparatus according claim 1, wherein said chemical is a hormone.

6. The apparatus according to claim 5, wherein said hormone is insulin.

7. The apparatus according to claim 1, wherein said chemical is glucose.

8. The apparatus according to claim 1, wherein said at least one implantable electrode is configured to be located in the GI tract.

9. The apparatus according to claim 8, wherein said at least one implantable electrode is configured to be located on the stomach.

10. The apparatus according to claim 1, wherein said implantable electrode is configured to be located adjacent to the pancreas.

11. A method for controlling the level of a chemical in the blood of a patient, comprising:

implanting at least one electrode adjacent to a portion of smooth muscle or a of said patient; and

electrifying said electrode with a non-excitatory electric field which does not generate excitation of said smooth muscle, wherein said non-excitatory electric field affects the activity of said smooth muscle in thereby controlling the level of said chemical in the patient'"'"'s blood stream.

12. The method according to claim 11, comprising measuring a level of said chemical in a blood stream.

13. The method according to claim 12, wherein electrifying said electrode with said non-excitatory electric field is responsive to the measured level.

14. The method according to claim 13, wherein said chemical is glucose.

15. The method according to claim 11, wherein said chemical is a hormone.

16. The method according to claim 15, wherein said hormone is insulin.

17. The method according to claim 11, wherein said chemical is glucose.

18. The method according to claim 11, wherein said at least one electrode is located in the GI tract.

19. The method according to claim 11, said electrode is adjacent to the pancreas.

20. The method according to claim 11, wherein said at least one electrode is located inside the body of the patient and outside a portion of the GI tract.

21. A method for controlling the level of a chemical in the blood of a patient, comprising:

placing at least one electrode adjacent to a portion of smooth muscle or a gland of said patient; and

electrifying said electrode with a non-excitatory electric field which does not generate excitation of said smooth muscle or gland, wherein said non-excitatory electric field affects the activity of said smooth muscle or gland in thereby controlling the level of said chemical in the patient'"'"'s blood stream,

wherein said at least one electrode is located in the GI tract on the stomach.