Microfluidic large scale integration
First Claim
1. A microfluidic device comprising:
- a first layer comprising a first side and including a first recess in said first side, said first recess comprising a curved surface;
a monolithic elastomeric second layer having a first side and a second side and including a second recess in said second side,wherein the first side of the second layer is in contact with the first side of the first layer, and the first side of the second layer and the first recess define a first microfluidic channel with a transverse cross-section that comprises a curved upper surface running lengthwise along the channel, thereby forming an arched profile,a third layer comprising a planar surface, wherein the planar surface is in contact with the second side of the elastomeric second layer and, the planar surface and the second recess define a second microfluidic channel with a transverse cross-section that comprises a curved upper surface running lengthwise along the channel, thereby forming an arched profile, the second fluidic channel crossing under the first microfluidic channel,wherein the first microfluidic channel and second microfluidic channels are separated by a membrane portion of the second layer, wherein the membrane portion of the second layer is;
deflectable into the first microfluidic channel in response to pressure within the second microfluidic channel anddeflectable into the second microfluidic channel in response to pressure within the first microfluidic channel.
2 Assignments
0 Petitions
Accused Products
Abstract
Using basic physical arguments, a design and method for the fabrication of microfluidic valves using multilayer soft lithography is presented. Embodiments of valves in accordance with the present invention feature elastomer membrane portions of substantially constant thickness, allowing the membranes to experience similar resistance to an applied pressure across their entire width. Such on-off valves fabricated with upwardly- or downwardly-deflectable membranes can have extremely low actuation pressures, and can be used to implement active functions such as pumps and mixers in integrated microfluidic chips. Valve performance was characterized by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and comparing them to both finite element simulations and alternative valve geometries.
-
Citations
16 Claims
-
1. A microfluidic device comprising:
-
a first layer comprising a first side and including a first recess in said first side, said first recess comprising a curved surface; a monolithic elastomeric second layer having a first side and a second side and including a second recess in said second side, wherein the first side of the second layer is in contact with the first side of the first layer, and the first side of the second layer and the first recess define a first microfluidic channel with a transverse cross-section that comprises a curved upper surface running lengthwise along the channel, thereby forming an arched profile, a third layer comprising a planar surface, wherein the planar surface is in contact with the second side of the elastomeric second layer and, the planar surface and the second recess define a second microfluidic channel with a transverse cross-section that comprises a curved upper surface running lengthwise along the channel, thereby forming an arched profile, the second fluidic channel crossing under the first microfluidic channel, wherein the first microfluidic channel and second microfluidic channels are separated by a membrane portion of the second layer, wherein the membrane portion of the second layer is; deflectable into the first microfluidic channel in response to pressure within the second microfluidic channel and deflectable into the second microfluidic channel in response to pressure within the first microfluidic channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
-
Specification