Measurement for EEG reactivity
First Claim
1. An apparatus for assessing physiological signal reactivity of a subject, the apparatus comprising:
- a first reception unit configured to receive a single continuous physiological signal from the subject;
a calculation unit configured to construct, based only on a time series of a physiological signal obtained from the subject, a signal model for the physiological signal;
a control unit configured to apply a single time reference to the time series corresponding to a stimulus supplied to the subject;
a second reception unit configured to receive further signal data from the time series of the physiological signal, the further signal data being obtained from the subject subsequent to the time reference;
a test unit configured to test, through employment of the signal model constructed from the physiological signal obtained at least partially prior to the single time reference and the further signal data obtained subsequent to the single time reference whether the signal model is a valid signal model for the physiological signal; and
an indicator unit, responsive to the test unit, configured to indicate, whether reactivity is present in the physiological signal.
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Abstract
The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a valid signal model is constructed for an EEG signal obtained from the subject. A time reference corresponding to a stimulus is applied and further signal data is obtained from the time series, the further signal data being subsequent to the time reference. By employing the further signal data, the method tests whether the signal model remains to be a valid signal model for the EEG signal also after the stimulus, and indicates, based on the test, whether reactivity is present in the physiological signal.
20 Citations
13 Claims
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1. An apparatus for assessing physiological signal reactivity of a subject, the apparatus comprising:
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a first reception unit configured to receive a single continuous physiological signal from the subject; a calculation unit configured to construct, based only on a time series of a physiological signal obtained from the subject, a signal model for the physiological signal; a control unit configured to apply a single time reference to the time series corresponding to a stimulus supplied to the subject; a second reception unit configured to receive further signal data from the time series of the physiological signal, the further signal data being obtained from the subject subsequent to the time reference; a test unit configured to test, through employment of the signal model constructed from the physiological signal obtained at least partially prior to the single time reference and the further signal data obtained subsequent to the single time reference whether the signal model is a valid signal model for the physiological signal; and an indicator unit, responsive to the test unit, configured to indicate, whether reactivity is present in the physiological signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An apparatus for assessing physiological signal reactivity of a subject in a single trial analysis, the apparatus comprising:
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a first reception means for receiving a single continuous physiological signal from the subject; calculation means for constructing, based only on a time series of a physiological signal obtained from the subject, a signal model for the physiological signal; control means for applying a single time reference to the time series corresponding to the time a stimulus is supplied; a second reception means for receiving further signal data from the time series of the physiological signal, the further signal data being obtained from the subject subsequent to the time reference; testing means for testing, through employment of the signal model constructed from the physiological signal obtained at least partially prior to the single time reference and further signal data obtained subsequent to the single time reference, whether the signal model is a valid signal model for the physiological signal; and indicator means, responsive to the test unit, for indicating, whether reactivity is present in the physiological signal.
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13. A computer program product embodied on a non-transitory computer-readable medium for assessing physiological signal reactivity of a subject, the computer program product comprising:
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a first program code portion configured to construct, based on a time series of a physiological signal obtained from the subject, a valid signal model for the physiological signal; a second program code portion configured to apply a single time reference to the time series corresponding to when a stimulus is supplied; a third program code portion configured to test, through employment of the signal model constructed from the physiological signal obtained at least partially prior to the single time reference and further signal data of the time series of the physiological signal, whether the signal model is a valid signal model for the physiological signal, wherein the further signal data is subsequent to the time reference; and a fourth program code portion, responsive to the third program code portion, configured to indicate whether reactivity is present in the physiological signal.
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Specification