Method and apparatus for automatically modifying delivery profile of drug delivery system
First Claim
1. A method of transferring fluid from an implantable drug delivery device that includes a reservoir, a fluid transfer device, and a catheter, the method comprising the steps of:
- transferring a first drug from the implantable drug delivery device in accordance with a first delivery profile after the first drug has been evacuated from the reservoir and replaced by a second drug;
monitoring the quantity of the first drug within the implantable drug delivery device by monitoring activity of the fluid transfer device after the first drug has been evacuated from the reservoir and replaced by a second drug; and
transferring the second drug from the reservoir to the catheter in accordance with a second delivery profile, which is different than the first delivery profile, in response to the first drug being cleared from the implantable drug delivery device in accordance with the first delivery profile.
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Accused Products
Abstract
The present invention relates to an implantable drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump or valve, and a drug delivery control means. The control means in accordance with the invention is configured to initially clear a first, or old, drug from the device based on the content of the Current Profile data containing a first, or old, delivery profile. After the old drug is cleared, then the control means automatically modifies the Current Profile data to match a second, or new, delivery profile for controlling delivery of a second, or new, drug.
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Citations
23 Claims
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1. A method of transferring fluid from an implantable drug delivery device that includes a reservoir, a fluid transfer device, and a catheter, the method comprising the steps of:
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transferring a first drug from the implantable drug delivery device in accordance with a first delivery profile after the first drug has been evacuated from the reservoir and replaced by a second drug; monitoring the quantity of the first drug within the implantable drug delivery device by monitoring activity of the fluid transfer device after the first drug has been evacuated from the reservoir and replaced by a second drug; and transferring the second drug from the reservoir to the catheter in accordance with a second delivery profile, which is different than the first delivery profile, in response to the first drug being cleared from the implantable drug delivery device in accordance with the first delivery profile. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of transferring fluid from an implantable drug delivery device that includes a reservoir, a fluid transfer device, and a catheter, the method comprising the steps of:
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transferring a first drug from the implantable drug delivery device in accordance with a first delivery profile, which specifies a schedule of at least two different flow rates during a delivery period of certain duration, after the first drug has been evacuated from the reservoir and replaced by a second drug; monitoring the quantity of the first drug within the implantable drug delivery device by monitoring activity of the fluid transfer device; and transferring the second drug from the reservoir to the catheter in accordance with a second delivery profile, which is different than the first delivery profile, in response to the first drug being cleared from the implantable drug delivery device in accordance with the first delivery profile.
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8. An implantable drug delivery device, comprising:
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a reservoir; an outlet; a fluid transfer device in fluid communication with the reservoir and the outlet; and a controller configured to control the fluid transfer device to transfer fluid in accordance with a first delivery profile after a first drug has been evacuated from the reservoir, to monitor the activity of the fluid transfer device, and to control the fluid transfer device to transfer fluid in accordance with a second delivery profile, which is different than the first delivery profile, in response to the monitored activity of the fluid transfer device after the first drug has been evacuated from the reservoir and replaced by a second drug indicating that the first drug has been cleared from the implantable drug delivery device. - View Dependent Claims (9, 10, 11, 12)
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13. An implantable drug delivery device, comprising:
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a reservoir; an outlet; a fluid transfer device in fluid communication with the reservoir and the outlet; and a controller configured to control the fluid transfer device to transfer fluid in accordance with a first delivery profile, which specifies a schedule of at least two different flow rates during a delivery period of certain duration, after a first drug has been evacuated from the reservoir, to monitor the activity of the fluid transfer device, and to control the fluid transfer device to transfer fluid in accordance with a second delivery profile, which is different than the first delivery profile, in response to the monitored activity of the fluid transfer device after the first drug has been evacuated from the reservoir and replaced by a second drug indicating that the first drug has been cleared from the implantable drug delivery device.
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14. An implantable drug delivery device that stores a total volume of fluid and includes a reservoir that stores a reservoir portion of the total volume of fluid, an outlet, and a fluid transfer device, wherein the improvement comprises:
a controller configured to monitor the actuations of the fluid transfer device, to actuate the fluid transfer device in accordance with a first delivery profile until the fluid transfer device has transferred a volume of fluid equal to the total volume of fluid less the reservoir portion, and to actuate the fluid transfer device in accordance with a second delivery profile, which is different than the first delivery profile, in response to a determination by the controller, based on monitored actuations of the fluid transfer device, that the fluid transfer device has transferred a volume of fluid equal to the total volume of fluid less the reservoir portion. - View Dependent Claims (15, 16, 17, 18)
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19. An implantable drug delivery device that stores a total volume of fluid and includes a reservoir that stores a reservoir portion of the total volume of fluid, an outlet, and a fluid transfer device, wherein the improvement comprises:
a controller configured to monitor the actuations of the fluid transfer device, to actuate the fluid transfer device in accordance with a first delivery profile, which specifies a schedule of at least two different flow rates during a delivery period of certain duration, until the fluid transfer device has transferred a volume of fluid equal to the total volume of fluid less the reservoir portion, and to actuate the fluid transfer device in accordance with a second delivery profile, which is different than the first delivery profile, in response to a determination by the controller, based on monitored actuations of the fluid transfer device, that the fluid transfer device has transferred a volume of fluid equal to the total volume of fluid less the reservoir portion.
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20. A method of operating an implantable drug delivery device including a reservoir, a fluid transfer device and a catheter, the method comprising:
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transferring a first drug from the reservoir to the catheter in accordance with a first delivery profile which specifies a schedule of at least two different flow rates during a delivery period of certain duration; transferring a second drug from the reservoir to the catheter in accordance with the at least two different flow rates of the first delivery profile, after the first drug has been evacuated from the reservoir in such a manner that a quantity of the first drug remains in the fluid transfer device and/or the catheter subsequent to the evacuation and after the reservoir has been filled with a second drug, so long as the first drug remains in the catheter; and transferring the second drug from the reservoir to the catheter in accordance with a second delivery profile, which is different than the first delivery profile, after the first drug has been cleared from the catheter in accordance with the at least two different flow rates of the first delivery profile. - View Dependent Claims (21, 22, 23)
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Specification