Systems and devices that utilize photolyzable nitric oxide donors

• US 8,221,690 B2
• Filed: 11/30/2007
• Issued: 07/17/2012
• Est. Priority Date: 10/30/2007
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Wood, Lowell L. Jr.
• Primary Examiner(s): Mayekar, Kishor
• Application Number:
  US11/998,864
• Publication Number:
  US 20090110958A1
• Time in Patent Office: 1,691 Days
• Field of Search: 422/186.3
• US Class Current: 422/186.3
• CPC Class Codes: A61N 1/3787 from an external energy source
• CPC Class Codes: A61N 2005/063 comprising light transmitting means, e.g. optical fibres
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 2005/0661 ultraviolet
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

The present disclosure relates to systems and devices that utilize photolyzable nitric oxide donors.

Claims

1. A device comprising:

one or more nitric oxide permeable housings, one or more photolyzable nitric oxide donors enclosed within the one or more nitric oxide permeable housings,

one or more light sources that are physically associated with the one or more photolyzable nitric oxide donors and enclosed within the one or more nitric oxide permeable housings; and

one or more control units that are operably associated with the one or more light sources.

2. The device of claim 1, wherein the one or more photolyzable nitric oxide donors comprise:

one or more photolyzable nitric oxide donors that include one or more diazeniumdiolates.

3. The device of claim 1, wherein the one or more photolyzable nitric oxide donors comprise:

one or more photolyzable nitric oxide donors that are associated with one or more quantum dots.

4. The device of claim 1, wherein the one or more photolyzable nitric oxide donors comprise:

one or more photolyzable nitric oxide donors that are associated with one or more rare-earth materials.

5. The device of claim 1, wherein the one or more light sources that are physically associated with the one or more photolyzable nitric oxide donors comprise:

one or more electromagnetic receivers.

6. The device of claim 1, wherein the one or more light sources that are physically associated with the one or more photolyzable nitric oxide donors comprise:

one or more light sources that are coated with at least one of the one or more photolyzable nitric oxide donors.

7. The device of claim 1, wherein the one or more light sources that are physically associated with the one or more photolyzable nitric oxide donors comprise:

one or more light sources that are associated with one or more optical waveguides.

8. The device of claim 1, wherein the one or more light sources that are physically associated with the one or more photolyzable nitric oxide donors comprise:

one or more light sources that are associated with one or more quantum dots.

9. The device of claim 1, wherein the one or more light sources that are physically associated with the one or more photolyzable nitric oxide donors comprise:

one or more light sources that are associated with one or more rare-earth materials.

10. The device of claim 1, wherein the one or more light sources that are physically associated with the one or more photolyzable nitric oxide donors comprise:

one or more light sources that emit infrared light.

11. The device of claim 1, wherein the one or more light sources that are physically associated with the one or more photolyzable nitric oxide donors comprise:

one or more light sources that are configured to emit light that specifically facilitates release of nitric oxide from the one or more nitric oxide donors.

12. The device of claim 1, wherein the one or more light sources that are physically associated with the one or more photolyzable nitric oxide donors comprise:

one or more light sources that are configured to emit light that is selected to avoid damaging one or more tissues.

13. The device of claim 1, wherein the one or more nitric oxide permeable housings comprise:

one or more nitric oxide permeable housings that include one or more nitric oxide permeable membranes.

14. The device of claim 1, wherein the one or more control units comprise:

one or more receivers that are configured to receive one or more signals.

15. The device of claim 1, wherein the one or more control units comprise:

one or more receivers that are configured to receive one or more signals from one or more sensors.

16. The device of claim 1, wherein the one or more control units comprise:

one or more control units that regulate the one or more light sources.

17. The device of claim 1, wherein the one or more control units comprise:

one or more control units that are responsive to one or more programs.

18. The device of claim 1, wherein the one or more control units comprise:

one or more control units that are responsive to one or more commands.

19. The device of claim 1, wherein the one or more control units comprise:

one or more control units that are responsive to one or more timers.

20. The device of claim 1, wherein the one or more control units comprise:

one or more control units that are associated with one or more transmitters.

21. The device of claim 1, wherein the one or more control units comprise:

one or more control units that include memory.

22. The device of claim 1, wherein the one or more control units comprise:

one or more control units that include memory having one or more associated programs.

23. The device of claim 1, further comprising:

one or more nitric oxide sensors.

24. The device of claim 23, wherein the one or more nitric oxide sensors comprise:

one or more nitric oxide sensors that are configured to detect nitric oxide.

25. The device of claim 23, wherein the one or more nitric oxide sensors comprise:

one or more nitric oxide sensors that are configured to detect one or more nitric oxide donors.

26. The device of claim 23, wherein the one or more nitric oxide sensors comprise:

one or more nitric oxide sensors that are operably associated with the one or more control units.

27. The device of claim 23, wherein the one or more nitric oxide sensors comprise:

one or more nitric oxide sensors that are configured to transmit one or more information packets.

28. The device of claim 23, wherein the one or more nitric oxide sensors comprise:

one or more nitric oxide sensors that are configured to transmit one or more signals.

29. The device of claim 1, wherein the one or more nitric oxide permeable housings comprise:

one or more nitric oxide permeable housings that are regulated by the one or more control units.

30. A device comprising:

one or more nitric oxide permeable housings,

one or more photolyzable diazeniumdiolates enclosed within the one or more nitric oxide permeable housings;

one or more light sources that are enclosed within the one or more nitric oxide permeable housings and configured to emit light that facilitates release of nitric oxide from the one or more photolyzable diazeniumdiolates; and

one or more sensors that are configured to detect nitric oxide.

31. A device comprising:

one or more nitric oxide permeable housings, one or more photolyzable diazeniumdiolates enclosed within the one or more nitric oxide permeable housings;

one or more rare earth materials that facilitate upconversion of light;

one or more light sources that are enclosed within the one or more nitric oxide permeable housings and configured to emit light that is upconverted by the one or more rare earth materials to facilitate release of nitric oxide from the one or more photolyzable diazeniumdiolates; and

one or more sensors that are configured to detect nitric oxide.