Antioxidant for use in cosmetic, medicated and pharmaceutical preparations

• US 8,221,746 B2
• Filed: 05/01/2009
• Issued: 07/17/2012
• Est. Priority Date: 05/02/2008
• Status: Active Grant

• Current Assignee: Medik8 Limited
• Original Assignee: Pangaea Laboratories Ltd.
• Inventors: Isaacs, Elliot James, Gregory, Emma
• Primary Examiner(s): Horlick, Kenneth R.
• Assistant Examiner(s): THOMAS, DAVID C
• Application Number:
  US12/434,409
• Publication Number:
  US 20090274677A1
• Time in Patent Office: 1,173 Days
• Field of Search: None
• US Class Current: 424/94.1
• CPC Class Codes: A61K 2800/31 Anhydrous
• CPC Class Codes: A61K 2800/522 Antioxidants; Radical scavengers
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth

Abstract

The invention provides the use a 2,2-dimethyl chroman as a SOD mimetic in a cosmetic preparation. Cosmetic preparations comprising a 2,2-dimethyl chroman as a SOD mimetic are described, as well as methods for treating or preventing free radical damage to skin cells and treating or preventing hair loss which comprise topical administration of a 2,2-dimethyl chroman as a SOD mimetic.

Claims

1. A cosmetic preparation comprising Lipochroman-6 (dimethyl methoxychromanol) as an antioxidant, wherein the Lipochroman-6 acts as a superoxide dismutase (SOD) mimetic, characterised in that the preparation further comprises one or more supplementary antioxidants selected from the group of catalase mimetics and derivatives thereof consisting of transition metal salts of PCA (pyrrolidone carboxylic acid), EUK-134 (chloro[[2,2′

-[1,2-ethanediylbis[nitrilo-κ

N)methylidyne]]bis[6-methoxyphenolato-κ

O]]]-manganese), and propyl gallate.

2. A cosmetic preparation as claimed in claim 1, in which the supplementary antioxidant is a transition metal salt of PCA.

3. A cosmetic preparation according to claim 2, in which the transition metal salt of PCA is a copper PCA.

4. A cosmetic preparation according to claim 1, in which the supplementary antioxidant is EUK-134.

5. A cosmetic preparation according to claim 1, which is a gel, cream, shampoo or anhydrous preparation.

6. A cosmetic preparation according to claim 1, in which the concentration of Lipochroman-6 is 0.1% or greater.

7. A cosmetic preparation as claimed in claim 1, in which the cosmetic preparation is formulated in two parts comprising a first aqueous part and a second part comprising a cream or anhydrous base.

8. A cosmetic preparation as claimed in claim 7, in which the first part is an aqueous gel comprising copper PCA and the second part is a cream or anhydrous base.

9. A cosmetic preparation as claimed in claim 8, in which the first part comprises solubilised lipochroman-6 and one or more of copper PCA, propyl gallate and citric acid, and the second part comprises ascorbic acid and/or tetrasubstituted lipophilic ascorbate in an anhydrous base.

10. A cosmetic preparation as claimed in claim 1, in which the pH of the cosmetic preparation is adjusted to 3 or below.

11. A cosmetic preparation as claimed in claim 1, wherein the cosmetic preparation further comprises copper PCA and propyl gallate at a reduced pH.

12. A cosmetic preparation as claimed in claim 1, wherein the cosmetic preparation further comprises a stabilizer selected from the group consisting of ferulic acid, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), tert-butylhydroquinone (TBHQ), sodium metabisulphite (SMBS) and vitamin E.

13. A cosmetic preparation as claimed in claim 1, wherein the cosmetic preparation further comprises one or more supplementary actives known to be beneficial in the treatment of hair loss or the promotion of hair growth selected from the group consisting of taurine, caffeine, saw palmetto, Pygeum africanum, Urtica dioica, minoxidil, azelaic acid, marine cartilage, hydrolysed keratin, biotin, niacin, panthenol, vitamin B6, zinc, copper peptides, horsetail silica, beta sitosterols, pycnogenol, white lupin, pumpkin seed, PABA, green tea extract, folic acid, iron, L-cysteine, magnesium and ginseng.

14. A cosmetic preparation as claimed in claim 1 further comprising ascorbic acid and/or tetrasubstituted lipophilic ascorbate in a single anhydrous formula.