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Complement inhibitors and uses thereof

  • US 8,221,756 B2
  • Filed: 03/11/2011
  • Issued: 07/17/2012
  • Est. Priority Date: 03/23/2000
  • Status: Expired due to Fees
First Claim
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1. A method of treating a disease or condition that is mediated by excessive or uncontrolled activation of the complement system comprising administering an antibody that binds complement component C2a or the C2a portion of complement component C2 or a C2a binding fragment thereof, wherein the molar ratio of antibody to C2 is one antibody molecule to two C2 or C2a molecules, and the antibody inhibits the classical or lectin complement activation more than 50%, wherein the disease or condition is tissue damage due to ischemia/reperfusion.

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