Nonwoven tissue scaffold

• US 8,221,780 B2
• Filed: 06/29/2006
• Issued: 07/17/2012
• Est. Priority Date: 04/20/2004
• Status: Active Grant

• Current Assignee: DePuy Synthes Products LLC (Johnson & Johnson)
• Original Assignee: DePuy Mitek Incorporated (Johnson & Johnson)
• Inventors: Dhanaraj, Sridevi, Kladakis, Stephanie M., Hammer, Joseph J., Shetty, Dhanuraj, Timmer, Mark
• Primary Examiner(s): Woodward, Cherie M
• Application Number:
  US11/427,477
• Publication Number:
  US 20070031470A1
• Time in Patent Office: 2,210 Days
• Field of Search: None
• US Class Current: 424/424
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/3872 Meniscus for implantation between the natural bone surfaces
• CPC Class Codes: A61F 2002/30766 Scaffolds for cartilage ingrowth and regeneration
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.

Claims

1. A method of surgically repairing meniscal defects, comprising:

providing a biocompatible tissue repair scaffold including a nonwoven polymeric material, the nonwoven polymeric material consisting of a density in the range of about 120 mg/cc to 360 mg/cc, and the tissue repair scaffold having a modulus of elasticity greater than 1.5 MPA or about 1.5 MPA and a suture pull-out strength greater than 6 N or about 6 N;

positioning the tissue repair scaffold in contact with a tissue defect in a meniscus; and

fixing tissue repair scaffold in position with sutures,

wherein the repair scaffold provides increased suture pull-out strength and thereby promotes healing of the meniscus.

2. The method of claim 1, wherein at least one bioactive substance effective to stimulate cell growth is implanted with the tissue repair scaffold.

3. The method of claim 2, wherein the bioactive substance is selected from the group consisting of a platelet rich plasma, cartilage-derived morphogenic proteins, recombinant human growth factors, and combinations thereof.

4. The method of claim 3, wherein the bioactive substance is rhGDF.

5. The method of claim 4, wherein the bioactive substance is rhGDF-5.