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Chimeric immunomodulatory compounds and methods of using the same-II

  • US 8,222,398 B2
  • Filed: 10/01/2008
  • Issued: 07/17/2012
  • Est. Priority Date: 06/21/2001
  • Status: Expired due to Term
First Claim
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1. A chimeric immunomodulatory compound (CIC) comprising a core structure with the formula [Nv]x

  • Sp, wherein Sp is a multivalent spacer moiety covalently bonded to X independently selected nucleic acid moieties (Nv), wherein the nucleic acid moieties are between 3 and 7 nucleotides, wherein X is at least 3, wherein said multivalent spacer moiety is selected from the group consisting of a polysaccharide, glycerol, substituted glycerol, tetraaminobenzene, heptaaminobetacyclodextrin, 1,3,5-trihydroxycyclohexane, pentaerythritol, 1,3-diamino-2-propanol, substituted derivatives of 1,3,-diamino-2-propanol, [propyloxymethyl]ethyl compounds, tetraaminopentaerythritol, 1,4,8,11-tetraazacyclotetradecane, 1,4,7,10-tetraazacyclododecane, polyethyleneimino, or a 2-(hydroxymethyl)ethyl moiety, and wherein said CIC further comprises at least one additional non-nucleic acid spacer moiety.

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