Method for adapting fractionation of a radiation therapy dose
First Claim
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1. A method of adapting a treatment plan, the method comprising:
- using a computer to prepare a treatment plan for a patient, the treatment plan including multiple treatment fractions each having a planned radiation dose to be delivered to the patient;
after the treatment plan is prepared, using a computer to identify a first position of a first structure relative to a second structure prior to delivering each one of the fractions,prior to delivering the present treatment fraction, using a computer to identify a second position of the first structure relative to the second structure;
using a computer to adjust the planned radiation dose to be delivered to the patient for the present treatment fraction based on the second position of the first structure relative to the second structure without replanning the treatment plan; and
delivering the adjusted planned radiation dose to the patient with a radiation delivery device.
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Abstract
A system and method of adapting a radiation therapy treatment plan for a patient by varying the fraction size delivered to the patient on any individual day, based at least partially on the use of daily patient registration (i.e., taking images of the patient before each fraction is delivered to see the position and size of the tumor on that day). The fraction size can be dynamically altered based upon the biology of the tumor.
170 Citations
39 Claims
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1. A method of adapting a treatment plan, the method comprising:
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using a computer to prepare a treatment plan for a patient, the treatment plan including multiple treatment fractions each having a planned radiation dose to be delivered to the patient; after the treatment plan is prepared, using a computer to identify a first position of a first structure relative to a second structure prior to delivering each one of the fractions, prior to delivering the present treatment fraction, using a computer to identify a second position of the first structure relative to the second structure; using a computer to adjust the planned radiation dose to be delivered to the patient for the present treatment fraction based on the second position of the first structure relative to the second structure without replanning the treatment plan; and delivering the adjusted planned radiation dose to the patient with a radiation delivery device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 39)
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17. A method of treating a patient with radiation therapy using a plurality of fractions to deliver a total planned radiation dose to a tumor volume that has a sensitive structure in physical proximity to a tumor volume, the method comprising:
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using a computer to prepare a treatment plan for a patient, the treatment plan including multiple treatment fractions each having a planned delivered dose; after the treatment plan is prepared, acquiring an image of the patient with an image acquisition device; using a computer to adjust the dose to be delivered for a given treatment fraction based on a position of the tumor volume relative to a sensitive structure shown in the acquired image; and delivering radiation, with a radiation delivery device, to the patient according to the treatment plan such that the adjusted dose is delivered to the patient. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A radiation therapy treatment system for adapting a treatment plan, the radiation therapy treatment system comprising:
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a radiation delivery device; and a computer processor operatively coupled to the radiation delivery device, the computer processor having a computer readable medium including instructions that cause the computer processor to generate a treatment plan for a patient, the treatment plan including multiple treatment fractions each having an associated planned delivered dose to be delivered to the patient, identify a first position of a first structure relative to a second structure prior to delivery of each one of the fractions, the identification being performed after the treatment plan is prepared, prior to delivery of the present treatment fraction, identify a second position of the first structure relative to the second structure, adjust the planned radiation dose to be delivered to the patient for the present treatment fraction based on the second position of the first structure relative to the second structure without the treatment plan being replanned, and instruct the radiation delivery device to deliver the adjusted planned radiation dose to the patient.
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38. A computer program stored on a non-transitory machine-readable medium capable of being executed by a computer, the computer program for use in a radiation therapy treatment system, the computer program comprising:
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a treatment plan module operable to generate a treatment plan for a patient, the treatment plan including multiple treatment fractions each having an associated planned delivered dose to be delivered to the patient; a patient position module operable to identify a first position of a first structure relative to a second structure prior to delivery of each one of the fractions, the identification being performed after the treatment plan is prepared; a fraction modification module operable to, prior to delivery of the present treatment fraction, identify a second position of the first structure relative to the second structure and adjust the planned radiation dose to be delivered to the patient for the present treatment fraction based on the second position of the first structure relative to the second structure without the treatment plan being replanned; and a treatment delivery module operable to instruct a radiation delivery device to deliver the adjusted planned radiation dose to the patient.
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Specification