Optical sensor assembly

• US 8,223,325 B2
• Filed: 09/21/2009
• Issued: 07/17/2012
• Est. Priority Date: 09/19/2008
• Status: Active Grant

• Current Assignee: Senseonics, Incorporated (Senseonics Holdings, Inc.)
• Original Assignee: Sensors For Medicine and Science Incorporated
• Inventors: O'Connor, Casey J., Ferraro, Daniel C., Colvin, Arthur E Jr.
• Primary Examiner(s): NGUYEN, TU T
• Application Number:
  US12/563,396
• Publication Number:
  US 20100073669A1
• Time in Patent Office: 1,030 Days
• Field of Search: None
• US Class Current: 356/218
• CPC Class Codes: G01J 3/02 Details
• CPC Class Codes: G01J 3/0256 Compact construction
• CPC Class Codes: G01J 3/0264 Electrical interface; User interface
• CPC Class Codes: G01J 3/0272 Handheld
• CPC Class Codes: G01J 3/4406 Fluorescence spectrometry
• CPC Class Codes: G01N 2021/6421 Measuring at two or more wavelengths
• CPC Class Codes: G01N 2021/6441 with two or more labels
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 21/55 Specular reflectivity
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G01N 21/77 by observing the effect on a chemical indicator
• CPC Class Codes: G01N 2201/022 Casings
• CPC Class Codes: G01N 2201/062 LED's

Abstract

The present invention provides systems and methods for measuring an analyte in a medium without exposing the medium to contamination. The systems and methods employ a novel combination of a small sensor device embedded in a Luer cap and capable of wirelessly transmitting data to a reading device.

Claims

1. A sensing apparatus comprising:

a housing having an external sleeve and a mating member housed within said external sleeve;

an optical-based sensor capable of measuring the presence of an analyte in an analyte containing medium, said sensor disposed within said mating member, wherein said sensor includes a body, internal circuitry, and an internal coil housed within its body, said internal coil being configured to wirelessly receive electrical power from an external power supply; and

drive circuitry configured to communicate power to and receive data from said sensor,

wherein said mating member is configured to mate with a device in contact with said medium containing said analyte to be measured such that said optical-based sensor is capable of contacting said analyte containing medium.

2. The sensing apparatus according to claim 1, wherein said sensor further comprises:

a light source for introducing light into a fluorescent indicator that interacts with said medium; and

a photodetector for detecting light emitted by said fluorescent indicator in response to the introduced light, and for outputting a signal proportional to the detected light, the response of the fluorescent indicator varying in accordance with the presence and concentration of an analyte in the medium.

3. The sensing apparatus according to claim 2, wherein said data comprises said signal output from said photodetector.

4. The sensing apparatus according to claim 1, wherein said drive circuitry is further configured to communicate data from said sensor to an external processing device.

5. The sensing apparatus according to claim 4, wherein said drive circuitry communicates said data from said sensor to said external processing device via a wireless communications interface.

6. The sensing apparatus according to claim 1, wherein said primary coil is disposed within said housing.

7. The sensing apparatus according to claim 1, wherein said primary coil is printed on a PCB substrate and mounted within coupling distance of said internal coil.

8. The sensing apparatus according to claim 1, wherein the housing is a Luer fitting.

9. The sensing apparatus according to claim 8, wherein the Luer fitting has an approximately six percent taper.

10. The sensing apparatus according to claim 1, wherein said analyte is glucose.

11. The sensing apparatus according to claim 1, wherein said sensor is configured to measure a more than one analyte.

12. The sensing apparatus according to claim 1, wherein said drive circuitry is configured to communicate power to and data from said sensor by electromagnetic induction.

13. The sensing apparatus according to claim 1, wherein said device is a syringe.

14. The sensing apparatus according to claim 1, wherein said device is a fluid line.

15. The sensing apparatus according to claim 1, wherein said drive circuitry is further configured to communicate data to said sensor.

16. A sensor system comprising:

a plurality of optical-based sensors for measuring the presence of an analyte in an analyte containing medium, each of said sensors being disposed a housing having an external sleeve and a mating member housed within said external sleeve, wherein each of said sensors includes a body, internal circuitry, and an internal coil housed within its body, said internal coil being configured to receive electrical power from an external power supply and to transmit data;

at least one reading device comprising drive circuitry coupled to a primary coil, said primary coil configured to transmit power to and receive data from said internal coil of said plurality of optical-based sensors; and

a processing device configured to interface with said reading device in order to receive said data from at least one of said plurality of optical-based sensors;

wherein said mating member of said housing is configured to mate with a device in contact with said medium containing said analyte to be measured such that said optical-based sensors are brought into contact with said analyte containing medium.

17. The sensor system according to claim 16, wherein said sensors further comprise:

a light source for introducing light into a fluorescent indicator that interacts with a medium; and

a photodetector for detecting light emitted by said fluorescent indicator in response to the introduced light, and for outputting a signal proportional to the detected light, the response of the fluorescent indicator varying in accordance with the presence and concentration of an analyte in the medium.

18. The sensor system according to claim 17, wherein said data comprises said signal output from said photodetector.

19. The sensor system according to claim 16, wherein said primary coil is printed on a PCB substrate and mounted within coupling distance of said internal coil of one of said plurality of optical-based sensors.

20. The sensor system according to claim 16, wherein said reading device communicates said data from said sensor to said processing device via a wireless communications interface.

21. The sensor system according to claim 16, wherein at least one of said housings is a Luer fitting.

22. The sensor system according to claim 16, wherein said analyte is glucose, O2 or CO2.

23. The sensor system according to claim 16, wherein the optical-based sensor of said at least one sensor apparatus is configured to measure more than one analyte.

24. The sensor system according to claim 16, wherein each sensor has a separate reading device associated with it.

25. The sensor system according to claim 16, wherein said reading device comprises a portable device capable of reading more than one of said plurality of sensors.

26. The sensor system according to claim 16, wherein said reading device is configured to read more than one of said plurality of sensors at a different preset interval.

27. The sensor system according to claim 16, wherein the reading device is configured to send data to said plurality of optical-based sensors.

28. A method of measuring the presence and concentration of an analyte in a medium comprising:

providing a sensing apparatus comprising a housing having an external sleeve and a mating member disposed within said external sleeve, said sensing apparatus further comprising an optical-based sensor disposed within the mating member of said housing, said optical-based sensor including a body, internal circuitry, and an internal coil housed within its body, wherein said internal coil is configured to receive electrical power from an external power supply;

mating said sensing apparatus with a device that configured to be in fluid communication with said medium containing said analyte to be measured,

exciting said internal coil by electromagnetic induction using a reading device;

receiving at the reading device data from the optical-based sensor relating to the presence of an analyte in a medium; and

transmitting said data to a processing device.

29. The method of measuring the presence and concentration of an analyte according to claim 28, wherein the internal coil is excited at predetermined intervals.

30. The method of measuring the presence and concentration of an analyte according to claim 29, wherein said data is transmitted to said processing device wirelessly.

31. The method of measuring the presence and concentration of an analyte according to claim 30, wherein said optical-based sensor comprises:

a light source for introducing light into a fluorescent indicator that interacts with a medium; and

a photodetector for detecting light emitted by said fluorescent indicator in response to the introduced light, and for outputting a signal proportional to the detected light, the response of the fluorescent indicator varying in accordance with the presence and quantity of an analyte in the medium.

32. The method of measuring the presence and concentration of an analyte according to claim 31, wherein said data comprises said signal output from said photodetector.

33. The method of measuring the presence and concentration of an analyte according to claim 29, wherein said housing is a Luer fitting.

34. The method of measuring the presence and concentration of an analyte according to claim 29, wherein the device is a fluid line.

35. The method of measuring the presence and concentration of an analyte according to claim 28, further comprising the step of sending data to said sensor.

36. A sensing apparatus comprising:

a housing having an cavity disposed in an outside surface of the housing;

an optical-based sensor capable of measuring the presence of an analyte in an analyte containing medium, said sensor disposed within said cavity in said housing, wherein said sensor includes a body, internal circuitry, and an internal coil housed within its body, said internal coil being configured to receive electrical power from an external power supply; and

drive circuitry configured to communicate power to and receive data from said sensor,

wherein said housing is configured to connect with a device in contact with said medium containing said analyte to be measured such that said optical-based sensor is capable of contacting said analyte containing medium.

37. The sensing apparatus of claim 36, wherein the internal coil is configured to wirelessly receive electrical power from the external power supply, and the drive circuitry configured to wirelessly communicate power to and data from said sensor.

38. The sensing apparatus of claim 36, wherein the internal coil is configured to receive electrical power from the external power supply, and the drive circuitry configured to communicate power to and data from said sensor, through a communication wire.

39. The sensing apparatus of claim 36, wherein said drive circuitry is further configured to send data to said sensor.