Method and apparatus for automated fluid transfer operations

• US 8,225,824 B2
• Filed: 11/14/2008
• Issued: 07/24/2012
• Est. Priority Date: 11/16/2007
• Status: Active Grant

• Current Assignee: ArXium, Inc. (Van Humbeck Family)
• Original Assignee: Intelligent Hospital Systems, Inc. (Van Humbeck Family)
• Inventors: Eliuk, Walter W., Rob, Ronald H., Deck, Dustin, Jones, Richard L., Doherty, Thom
• Primary Examiner(s): Maust, Timothy L
• Application Number:
  US12/271,828
• Publication Number:
  US 20090126825A1
• Time in Patent Office: 1,348 Days
• Field of Search: 141/1, 141/2, 141/5, 141/25, 141/27, 141/104, 141/330, 141/26, 141/94, 141/95, 141100-103, 141/114, 141/192, 141/198, 141/329
• US Class Current: 141/192
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like

Abstract

Automated system and techniques for controlling fluid transfers among medical containers such as syringes, vials and IV bag are disclosed. In one aspect, an automated method for substantially balancing a pressure within a medical container such as a vial with ambient pressure using a fluid transfer device such as a needled syringe is disclosed. In another aspect, an automated method for substantially removing a volume of air from a medical container such as an IV bag using a fast pull technique is disclosed.

Claims

1. An automated pharmaceutical processing system comprising:

a compounding chamber;

a syringe manipulator station disposed in the compounding chamber, the syringe manipulator station being configured to hold a syringe with a needle directed in a generally downward orientation for drawing fluid through the needle from an IV bag into the held syringe; and

a controller comprising a processor to receive instructions that, when executed by the processor, cause the processor to perform operations comprising

identifying a type or characteristic associated with the IV bag, wherein the type or characteristic is associated with an IV bag volume capacity or a bag size,

identifying a plunger motion profile to create a partial vacuum in the syringe to extract substantially all air from the IV bag without extracting a substantial quantity of fluid from the IV bag, wherein the plunger motion profile is based in part upon the identified type or characteristic of the IV bag and comprises one or more of a plunger acceleration phase, a plunger constant velocity phase, and a plunger deceleration phase,

identifying a disengagement motion profile comprising at least one of a disengagement acceleration phase, a disengagement constant velocity phase, and a disengagement deceleration phase,

actuating the syringe manipulator station to engage a fill port of the IV bag with the needle of the syringe,

actuating the syringe manipulator station to pull the plunger of the syringe according to the plunger motion profile, and

actuating the syringe manipulator station to move the fill port and the needle of the syringe out of engagement according to the disengagement motion profile.

2. The system of claim 1, wherein actuating the syringe manipulator station to move the fill port and the needle of the syringe out of engagement begins prior to completion of actuating the syringe manipulator station to pull the plunger of the syringe.

3. The system of claim 1, wherein the plunger motion profile is based on a predetermined pull volume.

4. The system of claim 1, wherein operations further comprise determining a time period to wait between actuating the syringe manipulator station to pull the plunger of the syringe and actuating the syringe manipulator station to move the fill port and the needle of the syringe out of engagement.

5. The system of claim 4, wherein the time period is based in part upon one or more of a cross-sectional area of the needle, a length of the needle and an estimated air volume in the IV bag.

6. The system of claim 1, wherein the disengagement motion profile comprises a first acceleration period which begins substantially upon fluid entry into the syringe.

7. The system of claim 6, wherein the syringe manipulator station further comprises one or more of an optical sensor, an acoustic sensor, an infrared sensor, a laser, and a photographic image monitor for recognizing introduction of fluid into the syringe.

8. The system of claim 6, wherein the operations further comprise detecting a change of torque indicative of completion of air transfer from the IV bag.

9. An automated method for performing a fluid transfer operation, the method comprising:

providing an IV bag at a fluid transfer station;

providing a first syringe at the fluid transfer station;

identifying a first characteristic of the IV bag, wherein the first characteristic is based on one or more of a volume capacity and a bag size;

identifying a predetermined volume of liquid for fluid transfer;

determining a plunger motion profile to create a vacuum in the syringe to extract substantially all air from the IV bag without extracting a substantial quantity of fluid from the IV bag, wherein the plunger motion profile is based in part upon the first characteristic of the IV bag and comprises one or more of a plunger acceleration phase, a plunger constant velocity phase, and a plunger deceleration phase;

determining a disengagement motion profile comprising at least one of a disengagement acceleration phase, a disengagement constant velocity phase, and a disengagement deceleration phase;

inserting a distal tip of a first needle of the first syringe into a fluid transfer port of the IV bag while the first needle of the first syringe is in a generally needle-down orientation and the fluid transfer port is in a generally upward orientation;

actuating a plunger of the first syringe according to the plunger motion profile,

extracting the distal tip of the first needle from the fluid transfer port of the IV bag according to the disengagement motion profile;

inserting the distal tip of a second needle of a second syringe into the fluid transfer port of the IV bag; and

extracting the predetermined volume of liquid from the IV bag.

10. The method of claim 9, further comprising:

identifying a second characteristic of the IV bag, wherein the second characteristic is based on one or more of the volume capacity, an average fill volume, the bag size, an empty bag weight, and a fluid density;

determining an initial fill volume of the IV bag based in part upon the second characteristic;

determining a withdrawal volume based in part on the initial fill volume;

setting the predetermined volume of liquid to the withdrawal volume prior to extracting the predetermined volume of liquid; and

introducing a medicament into the IV bag after extracting the predetermined volume of liquid to produce a desired concentration of the medicament in the IV bag.

11. The method of claim 10, further comprising weighing the IV bag prior to extracting the predetermined volume of liquid to determine a fill weight, wherein the initial fill volume is further based in part upon the fill weight.

12. The method of claim 10, further comprising:

parking the IV bag containing the desired concentration of the medicament at a parking station; and

drawing a second predetermined volume of the desired concentration of the medicament to be added to a drug order.

13. The method of claim 9, wherein extracting the predetermined volume of liquid from the IV bag occurs while the needle of the syringe is in the generally needle-down orientation and the fluid transfer port is in the generally upward orientation.

14. The method of claim 9, further comprising:

receiving a user-selectable dwell time, and

pausing for the user-selectable dwell time after completion of actuating the plunger of the first syringe according to the plunger motion profile and prior to extracting the distal tip of the first needle from the fluid transfer port of the IV bag according to the disengagement motion profile.

15. The method of claim 9, wherein the first needle and the second needle are the same needle.