Algorithm sensor augmented bolus estimator for semi-closed loop infusion system
First Claim
1. An article of manufacture containing code for predicting blood glucose concentration of a patient, comprising a computer-usable medium including at least one embedded computer program that is capable of causing at least one computer to perform:
- receiving at least one sensor signal input representative of current blood glucose concentration from a sensor;
inputting the at least one sensor signal input to a derivative predicted algorithm, wherein the derivative predicted algorithm utilizes at least one of current blood glucose concentration, meal carbohydrate content, sensor current sample at time period n, system calibration factor, and insulin-on-board at time period n;
determining future blood glucose concentration using the derivative predicted algorithm by calculating a first derivative of a sensor current sample from the at least one sensor signal input at time period n, and then calculating a first derivative of a sensor glucose value from the at least one sensor signal input using the first derivative of the sensor current sample; and
commanding an infusion device to perform a fluid delivery function based on the determined future blood glucose concentration.
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Abstract
An infusion system is for infusing a fluid into the body of a patient. The infusion system includes at least one sensor for monitoring blood glucose concentration of the patient and an infusion device for delivering fluid to the patient. The sensor produces at least one sensor signal input. The infusion device uses the at least one sensor signal input and a derivative predicted algorithm to determine future blood glucose levels. The infusion device delivers fluid to the patient when future blood glucose levels are in a patient'"'"'s target range. The infusion device is capable of suspending and resuming fluid delivery based on future blood glucose levels and a patient'"'"'s low shutoff threshold. The infusion device suspends fluid delivery when future blood glucose levels falls below the low shutoff threshold. The infusion device resumes fluid delivery when a future blood glucose level is above the low shutoff threshold.
81 Citations
24 Claims
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1. An article of manufacture containing code for predicting blood glucose concentration of a patient, comprising a computer-usable medium including at least one embedded computer program that is capable of causing at least one computer to perform:
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receiving at least one sensor signal input representative of current blood glucose concentration from a sensor; inputting the at least one sensor signal input to a derivative predicted algorithm, wherein the derivative predicted algorithm utilizes at least one of current blood glucose concentration, meal carbohydrate content, sensor current sample at time period n, system calibration factor, and insulin-on-board at time period n; determining future blood glucose concentration using the derivative predicted algorithm by calculating a first derivative of a sensor current sample from the at least one sensor signal input at time period n, and then calculating a first derivative of a sensor glucose value from the at least one sensor signal input using the first derivative of the sensor current sample; and commanding an infusion device to perform a fluid delivery function based on the determined future blood glucose concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An article of manufacture containing code for predicting blood glucose concentration of a patient, comprising a computer-usable medium including at least one embedded computer program that is capable of causing at least one computer to perform:
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receiving at least one sensor signal input representative of current blood glucose concentration from a sensor; inputting the at least one sensor signal input to a derivative predicted algorithm; determining future blood glucose concentration using the derivative predicted algorithm by calculating a first derivative of a sensor current sample from the at least one sensor signal input at time period n, and then calculating a first derivative of a sensor glucose value from the at least one sensor signal input using the first derivative of the sensor current sample, wherein the first derivative of the sensor current sample is calculated from a slope of the sensor current sample versus time using a Savitzky-Golay finite impulse response filter; and commanding an infusion device to perform a fluid delivery function based on the determined future blood glucose concentration. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification